Kinetics and mechanism of N-Boc cleavage: Evidence of a second-order dependence upon acid concentration

Journal of Organic Chemistry

Volumn 75, Issue 23, 2010, Pages 8117-8125

  Ashworth, Ian W ^a   Cox, Brian G ^a   Meyrick, Brian ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID CONCENTRATIONS; BUTYL CARBAMATE; DEPROTECTION; KINETICS AND MECHANISM; METHANE SULFONIC ACID; PROTONATED; RATE OF REACTION; SECOND-ORDER DEPENDENCE; THIOESTERS; TRIFLUOROACETATES; TRIFLUOROACETIC ACIDS;

CATALYSIS; METHANE; ORGANIC COMPOUNDS; REACTION RATES; SULFUR COMPOUNDS; TOLUENE;

SULFURIC ACID;

2 PROPANOL; ACID; AMINE; AZD 3409; CARBONYL DERIVATIVE; CHLORIDE; METHANE SULFONIC ACID; N TERT BUTYLOXYCARBONYL; SULFONIC ACID DERIVATIVE; SULFURIC ACID; THIOESTER; TOLUENE; TOLUENE DERIVATIVE; TOLUENESULFONIC ACID; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; CATALYSIS; CHEMICAL BINDING; CHEMICAL INTERACTION; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEPROTECTION REACTION; KINETICS; PROTON TRANSPORT; SYNTHESIS;

ACIDS; CARBAMATES; CATALYSIS; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE;

EID: 78650298804     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101767h     Document Type: Article

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