Subcutaneous pig islet xenografts: Getting under your skin to cure diabetes?

Transplantation

Volumn 90, Issue 10, 2010, Pages 1050-1051

  Cowan, Peter J ^a,b   D'Apice, Anthony J F ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; COLLAGEN; CYTOKINE; POLYMER; REACTIVE OXYGEN METABOLITE;

ADAPTIVE IMMUNITY; CYTOKINE RELEASE; DEVICE; DIABETES MELLITUS; DNA MODIFICATION; GLYCEMIC CONTROL; GRAFT DYSFUNCTION; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; HUMORAL IMMUNITY; HYPERGLYCEMIA; HYPOXIA; IMMUNOCOMPETENT CELL; IMMUNOGENICITY; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; MICROENCAPSULATION; MONOLAYER CELLULAR DEVICE; NONHUMAN; NOTE; ORGAN DONOR; OXIDATIVE STRESS; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RETRANSPLANTATION; SUBCUTANEOUS TISSUE; SWINE; TREATMENT OUTCOME; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; DIABETES MELLITUS; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MODELS, ANIMAL; PRIMATES; SUBCUTANEOUS TISSUE; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 78650292840     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181f6e286     Document Type: Note

References (6)

1. Hering BJ, Wijstrom M, Graham ML, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in im-munosuppressed nonhuman primates. Nat Med 2006;12:301.
2. Cardona K, Korbutt GS, Milas Z, et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006;12:304.
3. Cui H, Tucker-Burden C, Cauffiel SM, et al. Long-term metabolic control of autoimmune diabetes in spontaneously diabetic nonobese diabetic mice by nonvascularized microencapsulated adult porcine islets. Transplantation 2009;88:160.
4. Sun Y, Ma X, Zhou D, et al. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencap-sulated porcine islets without immunosuppression. J Clin Invest 1996;98:1417.
5. Dufrane D, Goebbels R, Gianello P. Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression. Transplantation (in press).
6. Mysore TB, Shinkel TA, Collins J, et al. Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes 2005;54:2109.