The poly A polymerase Star-PAP controls 3-2-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA

EMBO Journal

Volumn 29, Issue 24, 2010, Pages 4132-4145

  Laishram, Rakesh S ^a   Anderson, Richard A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

3' end RNA processing; phosphoinositides; PI4,SP 2; poly A polymerase; Star PAP

Indexed keywords

CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; HEME OXYGENASE 1; MESSENGER RNA; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; SMALL INTERFERING RNA; STAR POLYNUCLEOTIDE ADENYLYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; PHENOTYPE; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA PROCESSING; UNTRANSLATED REGION;

CELL EXTRACTS; CELL LINE; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; GENE KNOCKDOWN TECHNIQUES; HEME OXYGENASE-1; HUMANS; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, SMALL INTERFERING; SENSITIVITY AND SPECIFICITY;

EID: 78650266656     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.287     Document Type: Article

References (60)

1. 0-end processing machinery in RNAP II-dependent gene looping. Genes Dev 19: 2969-2978
2. Auboeuf D, Dowhan DH, Dutertre M, Martin N, Berget SM, O'Malley BW (2005) A subset of nuclear receptor coregulators act as coupling proteins during synthesis and maturation of RNA transcripts. Mol Cell Biol 25: 5307-5316
3. Barabino SM, Hubner W, Jenny A, Minvielle-Sebastia L, Keller W (1997) The 30-kD subunit of mammalian cleavage and polyade-nylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. Genes Dev 11 : 1703-1716
4. 0-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition. Cell 65: 125-133
5. Barlow CA, Laishram RS, Anderson RA (2009) Nuclear phosphoi-nositides: a signaling enigma wrapped in a compartmental conundrum. Trends Cell Biol 20: 25-35
6. Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1998) Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell 9: 3547-3560
7. 0 processing by human cleavage factor Im. Mol Cell 12: 1467-1476
8. Colgan DF, Manley JL (1997) Mechanism and regulation of mRNA polyadenylation. Genes Dev 11 : 2755-2766
9. Damgaard CK, Dyhr-Mikkelsen H, Kjems J (1998) Mapping the RNA binding sites for human immunodeficiency virus type-1 gag and NC proteins within the complete HIV-1 and -2 untranslated leader regions. Nucleic Acids Res 26: 3667-3676
10. 0-AAUAAA motif and its flanking sequence in human RNA: relevance to cDNA library sorting. Gene 11 0 : 245-249
11. de Vries H, Ruegsegger U, Hubner W, Friedlein A, Langen H, Keller W (2000) Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. EMBO J 19: 5895-5904
12. Dignam JD, Lebovitz RM, Roeder RG (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11 : 1475-1489
13. 0 end of histone mRNA: getting closer to the end. Gene 396: 373-390
14. Edmonds M (2002) A history of poly A sequences: from formation to factors to function. Prog Nucleic Acid Res Mol Biol 71 : 285-389
15. Gilbert C, Kristjuhan A, Winkler GS, Svejstrup JQ (2004) Elongator interactions with nascent mRNA revealed by RNA immunopreci-pitation. Mol Cell 14: 457-464
16. 0-processing enhancer: multiple sequence contacts involved in poly(A) site definition. Genes Dev 9: 72-83
17. Gilmartin GM, Nevins JR (1991) Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA. Mol Cell Biol 11 : 2432-2438
18. Gonzales ML, Mellman DL, Anderson RA (2008) CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem 283: 12665-12673
19. Heck JN, Mellman DL, Ling K, Sun Y, Wagoner MP, Schill NJ, Anderson RA (2007) A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. Crit Rev Biochem Mol Biol 42: 15-39
20. Hirose Y, Manley JL (2000) RNA polymerase II and the integration of nuclear events. Genes Dev 14: 1415-1429
21. 0 processing complexes. EMBO J 6: 4159-4168
22. Jenny A, Hauri HP, Keller W (1994) Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. Mol Cell Biol 14: 8183-8190
23. Kaufmann I, Martin G, Friedlein A, Langen H, Keller W (2004) Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. EMBO J 23: 616-626
24. 0 processing signal AAUAAA. EMBO J 10: 4241-4249
25. 0-end maturation. EMBO Rep 9: 1013-1018
26. Laishram RS, Gowrishankar J (2007) Environmental regulation operating at the promoter clearance step of bacterial transcription. Genes Dev 21: 1258-1272
27. Lutz CS, Murthy KG, Schek N, O'Connor JP, Manley JL, Alwine JC (1996) Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes Dev 10 : 325-337
28. MacDonald CC, Wilusz J, Shenk T (1994) The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location. Mol Cell Biol 14: 6647-6654
29. Maines MD, Gibbs PE (2005) 30 some years of heme oxygenase: from a 'molecular wrecking ball' to a 'mesmerizing' trigger of cellular events. Biochem Biophys Res Commun 338: 568-577
30. 0 -end processing. Cell Mol Life Sci 65: 1099-1122
31. 0-end- processing endonuclease. Nature 444: 953-956
32. Maniatis T, Reed R (2002) An extensive network of coupling among gene expression machines. Nature 416: 499-506
33. Martin G, Keller W (1996) Mutational analysis of mammalian poly(A) polymerase identifies a region for primer binding and catalytic domain, homologous to the family X polymerases, and to other nucleotidyltransferases. EMBO J 15: 2593-2603
34. Mellman DL, Gonzales ML, Song C, Barlow CA, Wang P, Kendziorski C, Anderson RA (2008) A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature 451: 1013-1017
35. Mendez R, Murthy KG, Ryan K, Manley JL, Richter JD (2000) Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol Cell 6: 1253-1259
36. Moore MJ, Proudfoot NJ (2009) Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 136: 688-700
37. Murakawa GJ, Nierlich DP (1989) Mapping the lacZ ribosome binding site by RNA footprinting. Biochemistry 28: 8067-8072
38. Murthy KG, Manley JL (1992) Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus. J Biol Chem 267: 14804-14811
39. 0-end formation. Genes Dev 9: 2672-2683
40. Nielsen DA, Shapiro DJ (1986) Preparation of cap RNA transcript using t7 RNA polymerase. Nucleic Acid Res 14: 5936
41. Okada M, Jang SW, Ye K (2008) Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY. Proc Natl Acad Sci USA 105: 8649-8654
42. Proudfoot N, O'Sullivan J (2002) Polyadenylation: a tail of two complexes. Curr Biol 12: R855-R857
43. 0-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage. Mol Cell Biol 28: 849-862
44. 0 end processing of messenger RNA precursors. J Biol Chem 271: 6107-6113
45. 0 processing endonuclease. RNA 10 : 565-573
46. 0-end formation. Mol Cell Biol 9: 4229-4238
47. Sheets MD, Ogg SC, Wickens MP (1990) Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro. Nucleic Acids Res 18: 5799-5805
48. Takagaki Y, Manley JL, MacDonald CC, Wilusz J, Shenk T (1990) A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. Genes Dev 4: 2112-2120
49. Takagaki Y, Ryner LC, Manley JL (1988) Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation. Cell 52: 731-742
50. 0-end cleavage of pre-mRNAs. Genes Dev 3: 1711-1724
51. Tan-Wong SM, Wijayatilake HD, Proudfoot NJ (2009) Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex. Genes Dev 23: 2610-2624
52. Trippe R, Guschina E, Hossbach M, Urlaub H, Luhrmann R, Benecke BJ (2006) Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. RNA 12: 1494-1504
53. Wahle E (1991a) A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenyla-tion. Cell 66: 759-768
54. 0 end processing of messenger RNA precursors. J Biol Chem 266: 3131-3139
55. 0-End processing of pre-mRNA in eukaryotes. FEMS Microbiol Rev 23: 277-295
56. Weiss EA, Gilmartin GM, Nevins JR (1991) Poly(A) site efficiency reflects the stability of complex formation involving the downstream element. EMBO J 10 : 215-219
57. 0 end formation. Science 226: 1045-1051
58. 0 hydroxyl of the U in AAUAAA. Mol Cell Biol 10 : 1705-1713
59. Wilusz J, Shenk T, Takagaki Y, Manley JL (1990) A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates. Mol Cell Biol 10: 1244-1248
60. 0 ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiol Mol Biol Rev 63: 405-445