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78650289579
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For a summary of other oxidants that effect this conversion but find less use see ref 16
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For a summary of other oxidants that effect this conversion but find less use see ref 16.
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78650275568
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2′ mechanism
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2′ mechanism.
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30
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0141741604
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The log of the ratio of products obtained was used for these plots because (assuming the reaction is irreversible under the reaction conditions) these values are directly related to the free energy difference between the regioisomeric transition states. This relationship is analogus to using log(er) for Hammett plots of results obtained for enantioselective reactions. For an example of the use of log(er) in Hammett plots see
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The log of the ratio of products obtained was used for these plots because (assuming the reaction is irreversible under the reaction conditions) these values are directly related to the free energy difference between the regioisomeric transition states. This relationship is analogus to using log(er) for Hammett plots of results obtained for enantioselective reactions. For an example of the use of log(er) in Hammett plots see: Constantine, R. N.; Kim, N.; Bunt, R. C. Org. Lett. 2003, 5, 2279
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38
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78650274185
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The hydrazones could also be prepared by mixing the ketone, 4-chlorophenyl hydrazine hydrochloride, and sodium acetate in ethanol under an atmosphere of nitrgen. The mixture was stirred at room temperature or heated to reflux (for sterically encumbered ketones) and the progress of the reaction was monitored by TLC. Upon completion, the solvent was removed in vacuo to provide the hydrazone, which could be further purified by dissolving the residue in pentane and passing the mixture through a short plug of basic alumina
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The hydrazones could also be prepared by mixing the ketone, 4-chlorophenyl hydrazine hydrochloride, and sodium acetate in ethanol under an atmosphere of nitrgen. The mixture was stirred at room temperature or heated to reflux (for sterically encumbered ketones) and the progress of the reaction was monitored by TLC. Upon completion, the solvent was removed in vacuo to provide the hydrazone, which could be further purified by dissolving the residue in pentane and passing the mixture through a short plug of basic alumina.
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40
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78650282374
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The aryl-α-chloroazoalkane products were moderately stable, but decomposed on standing. Attempts to send the sample for exact mass determination failed to provide useful data
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The aryl-α-chloroazoalkane products were moderately stable, but decomposed on standing. Attempts to send the sample for exact mass determination failed to provide useful data.
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