Temporal trends and associated factors for pre-hospital and in-hospital delays of stroke patients over a 16-year period: The Athens study

Cerebrovascular Diseases

Volumn 31, Issue 2, 2011, Pages 199-206

  Papapanagiotou, Panagiotis ^a   Iacovidou, Nicoletta ^a   Spengos, Konstantinos ^b   Xanthos, Theodoros ^a   Zaganas, Ioannis ^c   Aggelina, Afrodite ^a   Alegakis, Athanasios ^a   Vemmos, Konstantinos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Delays, pre hospital, in hospital; Stroke; Thrombolysis; Time trends

Indexed keywords

FIBRINOLYTIC AGENT;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EMERGENCY CARE; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; FEMALE; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; STROKE; STROKE PATIENT; TREND STUDY; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BRAIN ISCHEMIA; CHI-SQUARE DISTRIBUTION; DATABASES AS TOPIC; EMERGENCY MEDICAL SERVICES; EMERGENCY SERVICE, HOSPITAL; FEMALE; GREECE; HEALTH SERVICES ACCESSIBILITY; HUMANS; INPATIENTS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); PROSPECTIVE STUDIES; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 78650250894     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321737     Document Type: Article

References (36)

1. Tissue plasminogen activator for acute ischemic stroke: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995; 333: 1581-1587.
2. Adams HP, Brott TG, Furlan AJ, et al: Guidelines for thrombolytic therapy for acute stroke: a Supplement to the Guidelines for the Management of Patients with Acute Ischemic Stroke. A statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. Stroke 1996; 27: 1711-1718.
3. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, ECASS Investigators: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008; 359: 1317-1329.
4. Del Zoppo GJ, Saver JL, Jauch EC, Adams HP Jr, American Heart Association Stroke Council: Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American Heart Association/American Stroke Association. Stroke 2009; 40: 2945-2948.
5. European Stroke Organization (ESO) Executive Committee, ESO Writing Committee: Guidelines for management of ischaemic stroke and transient ischaemic attack. Cerebrovasc Dis 2008; 25: 457-507.
6. Heuschmann PU, Berger K, Misselwitz B, Hermanek P, Leffmann C, Adelmann M, Buecker-Nott HJ, Rother J, Neundoerfer B, Kolominsky-Rabas PL, German Stroke Registers Study Group: Frequency of thrombolytic therapy in patients with acute ischemic stroke and the risk of in-hospital mortality. Stroke 2003; 34: 1106-1113.
7. Reeves MJ, Arora S, Broderick JP, Frankel M, Heinrich JP, Hickenbottom S, Karp H, La- Bresh KA, Malarcher A, Mensah G, Moomaw CJ, Schwamm L, Weiss P: Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry. Stroke 2005; 36: 1232-1240.
8. Herderschee D, Limburg M, Hijdra A, Bollen A, Pluvier J, te Water W: Timing of hospital admission in a prospective series of stroke patients. Cerebrovasc Dis 1991; 1: 165-167.
9. Harper GD, Haigh RA, Potter JF, Castleden CM: Factors delaying hospital admission after stroke in Leicestershire. Stroke 1992; 23: 835-838.
10. Feldmann E, Gordon N, Brooks JM, Brass LM, Fayad PB, Sawaya KL, Nazareno F, Levine SR: Factors associated with early presentation of acute stroke. Stroke 1993; 24: 1805-1810.
11. Ferro JM, Melo TP, Oliveira V, Crespo M, Canhao P, Pinto AN: An analysis of the admission delay of acute strokes. Cerebrovasc Dis 1994; 4: 72-75.
12. Wester P, Rådberg J, Lundgren B, Peltonen M: Factors associated with delayed admission to hospital and in-hospital delays in acute stroke and TIA: a prospective, multicenter study. Seek-Medical-Attention- in- Time Study Group. Stroke 1999; 30: 40-48.
13. Morris DL, Rosamond W, Madden K, Schultz C, Hamilton S: Pre-hospital and emergency department delays after acute stroke: the Genentech Stroke Presentation Survey. Stroke 2000; 31: 2585-2590.
14. Derex L, Adeleine P, Nighoghossian N, Honnorat J, Trouillas P: Factors influencing early admission in a French stroke unit. Stroke 2002; 33: 153-159.
15. Koutlas E, Rudolf J, Grivas G, Fitsioris X, Georgiadis G: Factors influencing the pre- and in-hospital management of acute stroke - data from a Greek tertiary care hospital. Eur Neurol 2004; 51: 35-37.
16. Agyeman O, Nedeltchev K, Arnold M, Fischer U, Remonda L, Isenegger J, Schroth G, Mattle HP: Time to admission in acute ischemic stroke and transient ischemic attack. Stroke 2006; 37: 963-966.
17. Maestroni A, Mandelli C, Manganaro D, et al: Factors influencing delay in presentation for acute stroke in an emergency department in Milan, Italy. Emerg Med J 2008; 25: 340-345.
18. Vemmos KN, Takis CE, Georgilis K, Zakopoulos NA, Lekakis JP, Papamichael CM, Zis VP, Stamatelopoulos S: The Athens stroke registry: results of a five-year hospital-based study. Cerebrovasc Dis 2000; 10: 133-141.
19. Adams HP Jr, Brott TG, Crowell RM, et al: Guidelines for the management of patients with acute ischemic stroke: a statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation 1994; 90: 1588-1601.
20. The European Ad Hoc Consensus Group: Optimizing intensive care in stroke: a European perspective. Cerebrovasc Dis 1997; 7: 113-128.
21. Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Rorick M, Moomaw CJ, Walker M: Measurements of acute cerebral infarction: a clinical examination scale. Stroke 1989; 20: 864-870. (Pubitemid 19188240)
22. Lindestrom E, Boysen G, Christiansen LW, à Rogvi-Hansen B, Nielsen PW: Reliability of Scandinavian Neurological Stroke Scale. Cerebrovasc Dis 1991; 1: 103-111.
23. Gray LJ, Ali M, Lyden PD, Bath PM: Interconversion of the National Institutes of Health Stroke Scale and Scandinavian Stroke Scale in acute stroke. J Stroke Cerebrovasc Dis 2009; 18: 466-468.
24. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35-41.
25. Caplan LR, Stein RW: Stroke - A Clinical Approach. Boston, Butterworths, 1986, pp 11-12.
26. Evenson KR, Foraker RE, Morris DL, Rosamond WD: A comprehensive review of prehospital and in-hospital delay times in acute stroke care. Int J Stroke 2009; 4: 187-99.
27. Lichtman JH, Watanabe E, Allen NB, Jones SB, Dostal J, Goldstein LB: Hospital arrival time and intravenous t-PA use in US academic medical centers, 2001-2004. Stroke 2009; 40: 3845-3850.
28. Schneider AT, Pancioli AM, Khoury JC, Rademacher E, Tuchfarber A, Miller R, Woo D, Marler JR, Jones PW, Emr M: Proceedings of a national symposium on rapid identification and treatment of acute stroke. Washington, 1996.
29. Belvis R, Cocho D, Marti-Fabregas J, Pagonabarraga J, Aleu A, Garcia-Bargo MD, Pons J, Coma E, García-Alfranca F, Jimenez- Fabrega X, Marti-Vilalta JL: Benefits of a prehospital stroke code system: feasibility and efficacy in the first year of clinical practice in Barcelona, Spain. Cerebrovasc Dis 2005; 19: 96-101.
30. Behrens S, Daffertshofer M, Interthal C, Ellinger K, van Ackern K, Hennerici M: Improvement in stroke quality management by an educational programme. Cerebrovasc Dis 2002; 13: 262-266.
31. Lindsberg PJ, Happola O, Kallela M, Valanne L, Kuisma M, Kaste M: Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatment. Neurology 2006; 67: 334-336.
32. Appelros P, Jonsson F, Asplund K, Eriksson M, Glader EL, Asberg KH, Norrving B, Stegmayr B, Terént A, Riks-Stroke Collaboration: Trends in baseline patient characteristics during the years 1995-2008: observations from Riks-Stroke, the Swedish Stroke Register. Cerebrovasc Dis 2010; 30: 114-119.
33. Rowan SB, Bailey DN, Bublitz CE, Anderson RJ: Trends in anticoagulation for atrial fibrillation in the US: an analysis of the national ambulatory medical care survey database. J Am Coll Cardiol 2007; 49: 1561-1565.
34. Hannon N, Sheehan O, Kelly L, Marnane M, Merwick A, Moore A, Kyne L, Duggan J, Moroney J, McCormack P, Daly L, Fitz-Simon N, Harris D, Horgan G, Williams E, Furie K, Kelly P: Stroke associated with atrial fibrillation - incidence and early outcomes in the north Dublin population stroke study. Cerebrovasc Dis 2010; 29: 43-49.
35. Kaste M, Olsen TS, Orgogozo JM, Bogousslavsky J, Hacke W: Organization of stroke care: education, stroke units and rehabilitation, for the EUSI executive committee. Cerebrovasc Dis 2000; 10: 1-11.
36. Ringelstein EB, Meckes-Ferber S, Hacke W, Kaste M, Brainin M, Leys D, European Stroke Initiative executive committee: European Stroke Facilities Survey: the German and Austrian perspective. Cerebrovasc Dis 2009; 27: 138-145.