An efficient synthesis of α-methylene-β-butyrolactones from Baylis-Hillman adducts via an In-mediated Barbier reaction and stereoselective lactonization under MeSO2Cl/Et3N conditions

Tetrahedron Letters

Volumn 51, Issue 50, 2010, Pages 6568-6571

  Park, Bo Ram ^a   Kim, Ko Hoon ^a   Kim, Jae Nyoung ^a  

^a Chonnam National University   (South Korea)

Author keywords

Barbier reaction; Baylis Hillman adducts; Indium; Lactonization; Methylene butyrolactones

Indexed keywords

ALCOHOL; ALPHA METHYLENE BUTYROLACTONE DERIVATIVE; BROMINE DERIVATIVE; ESTER DERIVATIVE; GAMMA BUTYROLACTONE DERIVATIVE; MESYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BAYLIS HILLMAN REACTION; LACTONIZATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 78650239256     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.10.077     Document Type: Article

References (24)

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22. 3: C, 61.30; H, 5.94. Found: C, 61.54; H, 6.11.
23. 2: C, 64.73; H, 4.98. Found: C, 64.97; R 5.11.
24. 2: C, 82.58; H, 5.84. Found: C, 82.72; H, 6.03.