An expedient conversion of α-amino acids into Weinreb amides using COMU® As a coupling agent

Tetrahedron Letters

Volumn 52, Issue 3, 2011, Pages 369-372

  Tyrrell, Elizabeth ^a   Brawn, Peter ^a   Carew, Mark ^a   Greenwood, Iain ^b  

^a KINGSTON UNIVERSITY   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Amidation; Colorimetric changes; COMU ; Water soluble by products; Weinreb amides

Indexed keywords

ALPHA AMINO ACID; AMIDE; AMINE; N METHOXY N METHYLAMINE; UNCLASSIFIED DRUG; WATER;

ACYLATION; ARTICLE; BIOTRANSFORMATION; CHEMICAL REACTION; COLORIMETRY; CONTROLLED STUDY; CROSS COUPLING REACTION; RACEMIZATION; REACTION TIME; SOLUBILITY;

EID: 78650229299     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.10.169     Document Type: Article

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47. 27
48. HPLC was determined using a (Chiralcel-OD-H column) with a Waters 996 photodiode array diode detector. Measurements were made at 230 nm at a flow rate of 0.5 ml/min. Solvent, hexane/IPA (98:2).
49. The product is commercially available from Aldrich.
50. This resonance was only observed using DEPT Q.
51. This resonance was observed using HMBC.