A comparison of avalanche photodiode and photomultiplier tube detectors for flow cytometry

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6859, Issue , 2008, Pages

  Lawrence, William G ^a   Varadi, Gyula ^a   Entine, Gerald ^a   Podniesinski, Edward ^b   Wallace, Paul K ^b  

^a RADIATION MONITORING DEVICES INC   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

APD; avalanche photodiode; flow cytometry; infrared; IR

Indexed keywords

APD; APD DETECTORS; COEFFICIENT OF VARIATION; DYNAMIC RANGE; FLOW CYTOMETERS; FLUORESCENCE DETECTION; HUMAN BLOODS; INFRARED; IR; LABELED CELLS; LIMITED SENSITIVITY; LINEAR GAIN; LYMPHOCYTE POPULATION; MEAN FLUORESCENCE INTENSITIES; NEAR-INFRARED SPECTRAL REGIONS; PHOTO MULTIPLIER TUBE; PULSED LIGHT; QUANTUM DOT; RELATIVE PERFORMANCE; SIGNAL TO NOISE; SPECTRAL REGION; WAVELENGTH RANGES;

ANTIBODIES; AVALANCHE PHOTODIODES; BIOMOLECULES; DETECTORS; FLUORESCENCE; HISTOLOGY; INFRARED DEVICES; LIGHT EMISSION; LIGHT EMITTING DIODES; PHOTODIODES; PHOTOMULTIPLIERS; SIGNAL TO NOISE RATIO;

FLOW CYTOMETRY;

EID: 78650226368     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.758958     Document Type: Conference Paper

References (16)

1. Bonner WA, Hulett HR, Sweet RG, Herzenberg LA. Fluorescence Activated Cell Sorting. Rev. Sci. Instrum. 1972;43:404-409.
2. Roederer M, DeRosa S, Gerstein R, Anderson M, Bigos M, Stovel R, Naozaki T, Herzenberg L, Herzenberg L. 8 Color, 10-Parameter Flow Cytometry to Elucidate Complex Leukocyte Heterogeneity. Cytometry 1997;29:328-339.
3. DeRosa S, Herzenberg L, Herzenberg L, Roederer M. 11-color, 13-parameter flow cytometry: Identification of human niave T cells by phenotype, function and T-cell receptor diversity. Nature Medicine 2001;7(2):245.
4. Perfetto SP, Chattopadhyay PK, Roederer M. Seventeen-colour flow cytometry: unravelling the immune system. Nature 2004;4:648-655.
5. Stewart CC, Woodring ML, Podniesinski E, Gray B. Flow Cytometry in the Infrared: Inexpensive Modifications to a Commercial Instrument. Cytometry Part A 2005;67A:104-111.
6. Farrell R, Redus, R., Gordon, J. S., Gothoskar, P,. High Gain APD Array for Photon Detection. Proceedings SPIE 1995.;2550:266.
7. McClish M, Farrell R, Vanderpuye K, Shah KS. A Reexamination of Deep Diffused Silicon Avalanche Photodiode Gain and Quantum Efficiency. IEEE Transactions on Nuclear Science 2006;53(5):3049.
8. Sasaki DT, Maecker H, Trotter J. Establishing Optimum Baseline PMT Gains to Maximize Resolution on BD Biosciences Digital Flow Cytometers; 2005.
9. Chase ES, Hoffman RA. Resolution of Dimly Fluorescent Particles: A Practical Measure of Fluorescence Sensitivity. Cytometry 1998;33:267-279.
10. Steen HD. Noise, Sensitivity and Resolution of Flow Cytometers. Cytometry 1992;13:822-830.
11. Pinkel D, Steen HD. Simple Methods to Determine and Compare the Sensitivity of Flow Cytometers. Cytometry 1982;3(3):220-223.
12. Redus R, Farrell R. Gain and noise in very high gain avalanche photodiodes: theory and experiment. In: Hoover R, Doty P, editors; 1996. SPIE. p 288-297.
13. McIntyre RJ. Multiplication noise in uniform avalanche photodiodes. IEEE Transactions on Electron Devices 1966;ED-13:164-168.
14. Webb PP, McIntyre RJ, Conradi J. Properties of Avalanche Photodiodes. RCA Review 1974;35:234.
15. Teich MC, Matsuo K, Saleh BEA. Excess Noise Factors for Conventional and Superlattice Avalanche Photodiodes and Photomultiplier Tubes. IEEE Journal of Quantum Electronics 1986;QE-22(8):1184.
16. Ubezio P, Andreoni A. Linearity and Noise Sources in Flow Cytometry. Cytometry 1985;6:109-115.