Epstein-Barr virus and multiple sclerosis: Causation or association?

Future Microbiology

Volumn 5, Issue 11, 2010, Pages 1617-1619

  Kakalacheva, Kristina ^a   Comabella, Manuel ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b NONE

Author keywords

Epstein Barr virus; molecular mimicry; multiple sclerosis; virus induced autoimmunity

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; HLA DR ANTIGEN; IMMUNOGLOBULIN G; VIRUS DNA; VIRUS RNA;

ANTIGEN EXPRESSION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; EDITORIAL; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; EPSTEIN BARR VIRUS; FOLLOW UP; HEREDITY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; MOLECULAR MIMICRY; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; MULTIPLE SCLEROSIS;

HUMAN HERPESVIRUS 4;

EID: 78650215848     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/fmb.10.123     Document Type: Editorial

References (11)

1. Thacker EL, Mirzaei F, Ascherio A: Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann. Neurol. 59(3), 499-503 (2006). (Pubitemid 43358070)
2. Sundström P, Juto P, Wadell G et al.: An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology 62(12), 2277-2282 (2004).
3. Höllsberg P, Hansen HJ, Haahr S: Altered CD8+ T cell responses to selected Epstein- Barr virus immunodominant epitopes in patients with multiple sclerosis. Clin. Exp. Immunol. 132(1), 137-143 (2003).
4. Lünemann JD, Edwards N, Muraro P et al.: Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis. Brain 129(Pt 6), 1493-1506 (2006).
5. Lünemann JD, Jelcic I, Roberts S et al.: EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-g and IL-2. J. Exp. Med. 205(8), 1763-1773 (2008).
6. Jilek S, Schluep M, Meylan P et al.: Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis. Brain 131(Pt 7), 1712-1721 (2008).
7. Farrell RA, Antony D, Wall GR et al.: Humoral immune response to EBV in multiple sclerosis is associated with disease activity on MRI. Neurology 73(1) 32-38 (2009).
8. Lünemann JD, Tintoré M, Messmer B et al.: Elevated Epstein-Barr virus-encoded nuclear antigen-1 immune responses predict conversion to multiple sclerosis, Ann. Neurol. 67(2), 159-169 (2010).
9. Nielsen TR, Rostgaard K, Askling J et al.: Effects of infectious mononucleosis and HLA-DRB1*15 in multiple sclerosis. Mult. Scler. 15(4), 431-436 (2009).
10. Brennan RM, Burrows JM, Bell MJ: Strains of Epstein-Barr virus infecting multiple sclerosis patients. Mult. Scler. 16(6), 643-651 (2010).
11. Münz C, Lünemann JD, Getts MT, Miller SD: Antiviral immune responses: triggers of or triggered by autoimmunity? Nat. Rev. Immunol. 9(4), 246-258 (2009).