An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia

Psychiatry Research

Volumn 185, Issue 1-2, 2011, Pages 9-15

  Saito, Atsushi ^a   Fujikura Ouchi, Yuta ^b   Ito, Chihiro ^c   Matsuoka, Hiroo ^c   Shimoda, Kazutaka ^a   Akiyama, Kazufumi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b Kodama Hospital   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4); Growth arrest specific 2 like 1 (GAS2L1); Phosphoprotein enriched in astrocyte 15 (PEA15); Schizophrenia; Serial analysis of gene expression (SAGE)

Indexed keywords

CELL PROTEIN; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; GROWTH ARREST SPECIFIC 2 LIKE PROTEIN; PHOSPHOPROTEIN; PHOSPHOPROTEIN ENRICHED IN ASTROCYTE 15; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; JAPANESE; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LINKAGE DISEQUILIBRIUM; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PYROPHOSPHATASES; SCHIZOPHRENIA;

EID: 78650211601     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2009.09.018     Document Type: Article

References (31)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision 2000, American Psychiatric Association, Washington DC.
2. Biederbick A., Rose S., Elsässer H.-P. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. Journal of Cell Science 1999, 112:2473-2484.
3. Brancolini C., Bottega S., Schneider C. Gas2, a growth arrest-specific protein, is a component of the microfilament network system. The Journal of Cell Biology 1992, 117:1251-1261.
4. Brzustowicz L.M., Hodgkinson K.A., Chow E.W.C., Honer W.G., Bassett A.S. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000, 288:678-682.
5. Condorelli G., Vigliotta G., Cafieri A., Trencia A., Andalò P., Oriente F., Miele C., Caruso M., Formisano P., Beguinot F. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. Oncogene 1999, 18:4409-4415.
6. Condorelli G., Vigliotta G., Iavarone C., Caruso M., Tocchetti C.G., Andreozzi F., Cafieri A., Tecce M.F., Formisano P., Beguinot L., Beguinot F. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. The EMBO Journal 1998, 17:3858-3866.
7. Gabriel S.B., Schaffner S.F., Nguyen H., Moore J.M., Roy J., Blumenstiel B., Higgins J., DeFelice M., Lochner A., Faggart M., Liu-Cordero S.N., Rotimi C., Adeyemo A., Cooper R., Ward R., Lander E.S., Daly M.J., Altshuler D. The structure of haplotype blocks in the human genome. Science 2002, 296:2225-2229.
8. Goriounov D., Leung C.L., Liem R.K.H. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. Journal of Cell Science 2003, 116:1045-1058.
9. Gottfried Y., Rotem A., Klein E., Larisch S. The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients. Schizophrenia Research 2007, 96:257-266.
10. Gu C.C., Yu K., Rao D.C. Characterization of LD structures and the utility of HapMap in genetic association studies. Advances in Genetics 2008, 60:407-435.
11. Gurling H.M.D., Kalsi G., Brynjolfson J., Sigmundsson T., Sherrington R., Mankoo B.S., Read T., Murphy P., Blaveri E., McQuillin A., Petursson H., Curtis D. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. American Journal of Human Genetics 2001, 68:661-673.
12. Kendler K.S., Myers J.M., O'Neill F.A., Martin R., Murphy B., MacLean C.J., Walsh D., Straub R.E. Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p, and 10p in the Irish study of high-density schizophrenia families. The Amercan Journal of Psychiatry 2000, 157:402-408.
13. Lee K.K.H., Tang M.K., Yew D.T.W., Chow P.H., Yee S.P., Schneider C., Brancolini C. Gas2 is a multifunctional gene involved in the regulation of apoptosis and chondrogenesis in the developing mouse limb. Developmental Biology 1999, 207:14-25.
14. Liu Y.L., Fann C.S.J., Liu C.M., Chang C.C., Yang W.C., Hung S.I., Yu S.L., Hwang T.J., Hsieh M.H., Liu C.C., Tsuang M.M., Wu J.Y., Jou Y.S., Faraone S.V., Tsuang M.T., Chen W.J., Hwu H.-G. More evidence supports the association of PPP3CC with schizophrenia. Molecular Psychiatry 2007, 12:966-974.
15. Lohoff F.W., Ferraro T.N., McNabb L., Schwebel C., Dahl J.P., Doyle G.A., Buono R.J., Berrettini W.H. No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder. Psychiatry Research 2005, 135:171-177.
16. Morris D.W., Murphy K., Kenny N., Purcell S.M., McGhee K.A., Schwaiger S., Nangle J.-M., Donohue G., Clarke S., Scully P., Quinn J., Meagher D., Baldwin P., Crumlish N., O'Callaghan E., Waddington J.L., Gill M., Corvin A.P. Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Biological Psychiatry 2008, 63:24-31.
17. Nakata K., Ujike H., Sakai A., Takaki M., Imamura T., Tanaka Y., Kuroda S. The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia. Biological Psychiatry 2003, 53:571-576.
18. Newell-Litwa K., Seong E., Burmeister M., Faundez V. Neuronal and non-neuronal functions of the AP-3 sorting machinery. Journal of Cell Science 2007, 120:531-541.
19. Ni X., Valente J., Azevedo M.H., Pato M.T., Pato C.N., Kennedy J.L. Connexin 50 gene on human chromosome 1q21 is associated with schizophrenia in matched case-control and family-based studies. Journal of Medical Genetics 2007, 44:532-536.
20. Ouchi Y., Kubota Y., Kuramasu A., Watanabe T., Ito C. Gene expression profiling in whole cerebral cortices of phencyclidine- or methamphetamine-treated rats. Molecular Brain Research 2005, 140:142-149.
21. Perez-Iglesias R., Mata I., Relayo-Teran J.M., Amado J.A., Garcia-Unzueta M.T., Berja A., Martinez-Garcia O., Vazquez-Barquero J.L., Crespo-Facorro B. Glucose and lipid disturbances after 1year of antipsychotic treatment in a drug-naïve population. Schizophrenia Research 2009, 107:115-121.
22. Porton B., Ferreira A., DeLisi L.E., Kao H.-T. A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia. Biological Psychiatry 2004, 55:118-125.
23. Reif A., Fritzen S., Finger M., Strobel A., Lauer M., Schmitt A., Lesch K.-P. Neural stem cell proliferation is decreased in schizophrenia, but not in depression. Molecular Psychiatry 2006, 11:514-522.
24. Renault F., Formstecher E., Callebaut I., Junier M.-P., Chneiweiss H. The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes. Biochemical Pharmacology 2003, 66:1581-1588.
25. Saito A., Fujikura-Ouchi Y., Kuramasu A., Shimoda K., Akiyama K., Matsuoka H., Ito C. Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia. Neuroscience Letters 2007, 411:168-173.
26. Sengupta S., Parrilla-Escobar M.A., Klink R., Fathalli F., Ying K.N., Stip E., Baptista T., Malla A., Joober R. Are metabolic indices different between drug-naïve first-episode psychosis patients and healthy controls?. Schizophrenia Research 2008, 102:329-336.
27. Sharif A., Renault F., Beuvon F., Castellanos R., Canton B., Barbeito L., Junier M.P., Chneiweiss H. The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15KDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain. Neuroscience 2004, 126:263-275.
28. Takahashi S., Cui Y.-h., Kojima T., Han Y.-h., Zhou R.-l., Kamioka M., Yu S.-y., Matsuura M., Matsushima E., Wilcox M., Arinami T., Shen Y.-c., Faraone S.V., Tsuang M.T. Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 2003, 120B:11-17.
29. Toro C.T., Deakin J.F.W. Adult neurogenesis and schizophrenia: A window on abnormal early brain development?. Schizophrenia Research 2007, 90:1-14.
30. Whitehurst A.W., Robinson F.L., Moore M.S., Cobb M.H. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. The Journal of Biological Chemistry 2004, 279:12840-12847.
31. Wolford J.K., Bogardus C., Ossowski V., Prochazka M. Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. Gene 2000, 241:143-148.