Validation of an HPLC-FL method for the determination of tepoxalin and its major metabolite in horse plasma

Journal of Chromatographic Science

Volumn 49, Issue 1, 2011, Pages 79-83

  Giorgi, Mario ^a   Ye, Guisheng ^b   Sgorbini, Micaela ^a   Corazza, Michele ^a  

^a Department of Veterinary Clinics ^*  (Italy)

^b QINGHAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EQUIDAE;

EID: 78650193574     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chrsci/49.1.79     Document Type: Article

References (7)

1. D. C. Argentieri, D. M. Ritchie, M. P. Ferro, T. Kirchner, M. P. Wachter, D. W. Anderson, M. E. Rosenthal, and R. J. Capetola. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J. Pharmacol. Exp. Ther. 271:1399-1408 (1994).
2. L. M. Homer, C. R. Clarke, and A. J. Weingarten. Effect of dietary fat on oral bioavailability of tepoxalin in dogs. J. Vet. Pharmacol. Ther. 28:287-291 (2005).
3. S. A. Waldman, C. Vitow, B. Osborne, L. Gillen, D. C. Argentieri, F. A. Wong, I. L. Smith, A. T. Chow, J. Misiti, and T. D. Bjornsson. Pharmacokinetics and pharmacodynamics of tepoxalin after single oral dose administration to healthy volunteers. Clin. Pharmacol. 36:462-468 (1996).
4. C. G. Pollock, J. W. Carpenter, D. E. Koch, and R. P. Hunter. Single and multiple-dose pharmacokinetics of tepoxalin and its active metabolite after oral administration to rabbits (Oryctolagus cuniculus). J. Vet. Pharmacol. Ther. 31:171-174 (2008).
5. S. de Boever, E. Neirinckx, K. Baert, P. de Backer, and S. Croubels. Pharmacokinetics of tepoxalin and its active metabolite in broiler chickens. J. Vet. Pharmacol. Ther. 32:97-100 (2009).
6. Y. Vander Heyden, A. Nijhuis, J. Smeyers-Verbeke, B. G. M Vandeginste, and D. L. Massart. Guidance for robustness: ruggedness tests in method validation. J. Pharm. Biomed. Anal. 24:723-753 (2001).
7. D. J. Burinsky, B. L. Armstrong, A. R. Oyler, and R. Dunphy. Characterization of tepoxalin and its related compounds by high-performance liquid chromatography/mass spectrometry. Pharm. Sci. 85:159-164 (1996).