Protective role of ghrelin against carbon tetrachloride (CCl4)-induced coagulation disturbances in rats

Regulatory Peptides

Volumn 166, Issue 1-3, 2011, Pages 139-142

  Arici, Omer Faruk ^a   Çetin, Nazmi ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

Carbon tetrachloride; Coagulation disturbance; Ghrelin; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; CARBON TETRACHLORIDE; FIBRINOGEN; GHRELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; THROMBOCYTE COUNT;

ALANINE TRANSAMINASE; ANIMALS; BLOOD COAGULATION DISORDERS; CARBON TETRACHLORIDE POISONING; DRUG-INDUCED LIVER INJURY; FIBRINOGEN; GHRELIN; MALE; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; PROTHROMBIN TIME; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 78650176961     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2010.10.009     Document Type: Article

References (25)

1. Okazaki M., Furuya E., Shin Y., Sakamoto K. Studies on alterations in blood coagulative and fibrinolytic activities after single and multiple administrations of carbon tetrachloride in mice. Jpn J Pharmacol 1986, 41:447-458.
2. Vazquez C., Bujan J., Vallejo D D. Blood coagulation variations induced by carbon tetrachloride inhalation in Wistar rats. Toxicol Appl Pharmacol 1990, 103:206-213.
3. Kojima M., Kanagawa K. Ghrelin: structure and function. Physiol Rev 2005, 85:495-522.
4. Gonzalez-Rey E., Chorny A., Delgado M. Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology 2006, 130:1707-1720.
5. Li L., Zhang L.K., Pang Y.Z., Pan C.S., Qi Y.F., Chen L., Wang X., Tang C.S., Zhang J. Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Acta Pharmacol Sin 2006, 27:527-535.
6. Moreno M., Chaves J.F., Sancho-Bru P., Ramalho F., Ramalho L.N., Mansego M.L., Ivorra C., Dominguez M., Conde L., Millán C., Marí M., Colmenero J., Lozano J.J., Jares P., Vidal J., Forns X., Arroyo V., Caballería J., Ginès P., Bataller R. Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology 2010, 51:974-985.
7. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth hormone releasing acylated peptide from stomach. Nature 1999, 402:656-660.
8. Orwoll E.S., Orwoll R.L. Hematologic abnormalities in patients with endocrine and metabolic disorders. Hematol Oncol Clin North Am 1987, 1:261-279.
9. Negrev N., Nyagolov Y., Stanchewa E. Somatotropin and somatostatin effects on vitamin K-dependent plasma coagulation factors. Eur J Pharmacol 1995, 277:145-149.
10. Savendahl L.S., Grankvist K., Engstrom K.G. Growth hormone deficiency impairs blood clotting and reduces factor VII coagulant activity in rat. Thromb Haemost 1995, 73:626-629.
11. Ohta Y., Kongo-Nishimura M., Matsura T., Yamada K., Kitagawa A., Kishikawa T. Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride. J Pineal Res 2004, 36:36. 10-7.
12. Işeri S.O., Sener G., Saglam B., Ercan F., Gedik N., Yeǧen B.Ç. Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats. Regul Pept 2008, 146:73-79.
13. Amitrano L., Guardascione M.A., Brancaccio V., Balzano A. Coagulation disorders in liver disease. Semin Liver Dis 2002, 22:83-96.
14. Ishii H., Kuboki M., Ohkura M., Hiraishi S., Tsubouchi J., Kazama M. Effect of intraperitoneal injection of topical thrombin on the coagulation and fibrinolysis of rabbits with experimental liver damages. Nippon Yakurigaku Zasshi 1985, 85:97-110.
15. Tacke F., Brabant G., Kruck E., Horn R., Schöffski P., Hecker H., Manns M.P., Trautwein C. Ghrelin in chronic liver disease. J Hepatol 2003, 38:447-454.
16. Ekberg S., Luther M., Nakamura T., Jansson J.O. Growth hormone promotes early initiation of hepatocyte growth factor gene expression in the liver of hypophysectomized rats after partial hepatectomy. J Endocrinol 1992, 135:59-67.
17. Jeejeebhoy K.N., Bruce-Robertson A., Sodtke U., Foley M. Effect of growth hormone on fibrinogen synthesis. Biochem J 1970, 119:243-249.
18. Guillen M.I., Gomez-Lechon M.J., Nakamura T., Castell J.V. The hepatocyte growth factor regulates the synthesis of acute-phase proteins in human hepatocytes: divergent effect on interleukin-6-stimulated genes hepatology 23 1996, 1345-1352.
19. Landin-Wllhelmsen K., Wllhelmsen L., Lappast G., Rosen T., Lindstedt G., Lundberg P.A., Bengtsson B.A. Serum insulin-like growth factor I in a random population sample of men and women: relation to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol 1994, 41:351-357.
20. Ishiki Y., Ohnishi H., Muto Y., Matsumoto K., Nakamura T. Direct evidence that hepatocyte growth factor is hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo. Hepatology 1992, 16:1227-1235.
21. Isaksson O.G.P., Eden S., Jansson J. Mode of action of pituitary growth hormone on target cells. Ann Rev Physiol 1985, 47:483-499.
22. Liu J.L., LeRoith D. Insulin-like growth factor i is essential for postnatal growth in response to growth hormone. Endocrinology 1999, 140:5178-5184.
23. Miljic D., Miljic P., Doknic M., Pekic S., Djurovic M., Colovic M., Popovic V. Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adults. Hormones 2006, 5:187-191.
24. Parry B.W. Laboratory evaluation of hemorrhagic coagulopathies in small animal practice. Vet Clin North Am Small Anim Pract 1989, 19:729-742.
25. Fujiwara K., Ogata I., Ohta Y., Hirata K., Oka Y., Yamada S., Sato Y., Masaki N., Oka H. Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III. Gut 1988, 29:1103-1108.