Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: Effective protection by epigallocatechin-3-gallate

Free Radical Biology and Medicine

Volumn 49, Issue 12, 2010, Pages 2049-2057

  Mascia, Cinzia ^a   Maina, Marco ^a   Chiarpotto, Elena ^a   Leonarduzzi, Gabriella ^a   Poli, Giuseppe ^a   Biasi, Fiorella ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Colonic epithelial cells; Epigallocatechin 3 gallate; Flavonoids; Free radicals; IL 8; Inflammatory bowel disease; Inflammatory cytokines; Oxysterols

Indexed keywords

7BETA HYDROXYCHOLESTEROL; CASPASE 3; CHOLESTEROL; EPIGALLOCATECHIN GALLATE; INTERLEUKIN 1ALPHA; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; OXYSTEROL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 9;

ARTICLE; CELL DIFFERENTIATION; CELL PROTECTION; CHEMOTAXIS; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE CELL; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SUPPLEMENTATION; UPREGULATION;

ANTIOXIDANTS; APOPTOSIS; CACO-2 CELLS; CATECHIN; CHOLESTEROL; ENTEROCYTES; ENZYME ACTIVATION; HUMANS; HYDROXYCHOLESTEROLS; INFLAMMATION MEDIATORS; INTERLEUKIN-8; KETOCHOLESTEROLS; NADPH OXIDASE; ONIUM COMPOUNDS; UP-REGULATION;

EID: 78650175733     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.09.033     Document Type: Article

References (48)

1. G. Leonarduzzi, B. Sottero, and G. Poli Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects J. Nutr. Biochem. 13 2002 700 710
2. A.J. Brown, and W. Jessup Sources, cellular storage and metabolism and new insights into their roles in cholesterol metabolism Mol. Aspects Med. 30 2009 111 122
3. G. Poli, B. Sottero, S. Gargiulo, and G. Leonarduzzi Cholesterol oxidation products in the vascular remodeling due to atherosclerosis Mol. Aspects Med. 30 2009 180 189
4. I. Bjorkhem, A. Cedazo-Minguez, V. Leoni, and S. Meaney Oxysterols and neurodegenerative diseases Mol. Aspects Med. 30 2009 171 179
5. R. Ross Atherosclerosis is an inflammatory disease Am. Heart J. 138 1999 S419 S420
6. V.H. Perry, J.A. Nicoll, and C. Holmes Microglia in neurodegenerative disease Nat. Rev. Neurol. 6 2010 193 201
7. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
8. D. Steinberg Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime Nature 8 2002 1211 1217
9. M. Sjögren, M. Mielke, D. Gustafson, P. Zandi, and I. Skoog Cholesterol and Alzheimer's disease: is there a relation? Mech. Ageing Dev. 127 2006 138 147
10. I.I. Herbev, N.V. Ivankova, V.R. Katkoori, and O.A. Mamaeva Colorectal cancer and hypercholesterolemia: review of current research Exp. Oncol. 27 2005 166 178
11. A. Van Amerongen, R.A. Demel, J. Westerman, and K.W. Wirtz Transfer of cholesterol and oxysterol derivatives by the nonspecific lipid transfer protein (sterol carrier protein 2): a study on its mode of action Biochim. Biophys. Acta 1004 1989 36 43
12. C.C. Kan, J. Yan, and R. Bittman Rates of spontaneous exchange of synthetic radiolabeled sterols between lipid vesicles Biochemistry 31 1992 1866 1874
13. A. Vejux, and G. Lizard Cytotoxic effects of oxysterols associated with human diseases: induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis Mol. Aspects Med. 30 2009 153 170
14. D.K. Podolsky Inflammatory bowel disease N Engl J. Med. 347 2002 417 429
15. D.V. Ostanin, J. Bao, I. Koboziev, L. Gray, S.A. Robinson-Jackson, M. Kosloski-Davidson, V.H. Price, and M.B. Grisham T cell transfer model of chronic colitis: concepts, considerations and tricks of the trade Am. J. Physiol. Gastrointest. Liver Physiol. 296 2009 135 146
16. M. Rousset The human colon carcinoma cell lines HT-29 and Caco-2: two in vitro models for the study of intestinal differentiation Biochimie 68 1986 1035 1040
17. S. Howell, J.A. Kenny, and A.J. Turner A survey of membrane peptidases in two human colonic cell lines, CaCo-2 and HT-29 Biochem. J. 284 1992 595 601
18. J. Plat, J.A. Nichols, and R.P. Mensink Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation J. Lipid Res. 46 2005 2468 2476
19. J. Kanner Dietary advanced lipid oxidation endproducts are risk factors to human health Mol. Nutr. Food Res. 51 2007 1094 1101
20. F. Biasi, C. Mascia, M. Astegiano, E. Chiarpotto, M. Nano, B. Vizio, G. Leonarduzzi, and G. Poli Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: a potential mechanism of inflammatory bowel disease progression Free Radic. Biol. Med. 47 2009 1731 1741
21. I.J. Hidalgo, T.J. Raub, and R.T. Borchardt Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability Gastroenterology 96 1989 736 749
22. - ΔΔCT method Methods 25 2001 402 408
23. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
24. B. Sottero, P. Gamba, S. Gargiulo, G. Leonarduzzi, and G. Poli Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry Curr. Med. Chem. 16 2009 685 705
25. M. Rosenblat, and M. Aviram Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E Atherosclerosis 160 2002 69 80
26. E. Pedruzzi, C. Guichard, V. Ollivier, F. Driss, M. Fay, C. Prunet, J.C. Marie, C. Pouzet, M. Samadi, C. Elbim, Y. O'dowd, M. Bens, A. Vandewalle, M.A. Gougerot-Pocidalo, G. Lizard, and E. Ogier-Denis NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells Mol. Cell. Biol. 24 2004 10703 10717
27. G. Leonarduzzi, B. Vizio, B. Sottero, V. Verde, P. Gamba, C. Mascia, E. Chiarpotto, G. Poli, and F. Biasi Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol Antioxid. Redox Signaling 8 2006 375 380
28. Y. Steffen, I. Wiswedel, D. Peter, T. Schewe, and H. Sies Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7β-hydroxycholesterol to 7-ketocholesterol ratio Free Radic. Biol. Med. 41 2006 1139 1150
29. F. Biasi, G. Leonarduzzi, B. Vizio, D. Zanetti, A. Sevanian, B. Sottero, V. Verde, B. Zingaro, E. Chiarpotto, and G. Poli Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation FASEB J. 18 2004 693 695
30. B. Bai, K. Yamamoto, H. Sato, H. Sugiura, and T. Tanaka Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon carcinoma cell line (Caco-2) Inflammation 29 2005 141 146
31. S. Lemaire-Ewing, C. Prunet, T. Montange, A. Vejux, A. Berthier, G. Bessède, L. Corcos, P. Gambert, D. Néel, and G. Lizard Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols Cell Biol. Toxicol. 21 2005 97 114
32. G.J. Schroepfer Jr. Oxysterols: modulators of cholesterol metabolism and other processes Physiol. Rev. 80 2000 361 554
33. A.G. Erlejman, G. Jaggers, C.G. Fraga, and P.I. Oteiza TNFα-induced NF-κB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells Arch. Biochem. Biophys. 476 2008 186 195
34. T. Schewe, Y. Steffen, and H. Sies How do dietary flavanols improve vascular function?A position paper Arch. Biochem. Biophys. 476 2008 102 106
35. S. Wolfram Effects of green tea and EGCG on cardiovascular and metabolic health J. Am. Coll. Nutr. 26 2007 373S 388S
36. P. Velayutham, P.V. Babu, and D. Liu Green tea catechins and cardiovascular health: an update Curr. Med. Chem. 15 2008 1840 1850
37. L. Actis-Goretta, J.I. Ottaviani, and C.G. Fraga Inhibition of angiotensin converting enzyme activity by flavanol-rich foods J. Agric. Food Chem. 54 2006 229 234
38. H.L. Li, Y. Huang, C.N. Zhang, G. Liu, Y.S. Wei, A.B. Wang, Y.Q. Liu, R.T. Hui, C. Wei, G.M. Williams, D.P. Liu, and C.C. Liang Epigallocatechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways Free Radic. Biol. Med. 40 2006 1756 1775
39. H.C. Ou, T.Y. Song, Y.C. Yeh, C.Y. Huang, S.F. Yang, T.H. Chiu, K.L. Tsai, K.L. Chen, Y.J. Wu, C.S. Tsai, L.Y. Chang, W.W. Kuo, and S.D. Lee EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling J. Appl. Physiol. 108 2010 1745 1756
40. H. Nishikawa, K. Wakano, and S. Kitani Inhibition of NADPH oxidase subunits translocation by tea catechin EGCG in mast cell Biochem. Biophys. Res. Commun. 362 2007 504 509
41. B. Romier, Y.J. Schneider, Y. Larondelle, and A. During Dietary polyphenols can modulate the intestinal inflammatory response Nutr. Rev. 67 2009 363 378
42. J. Intra, and S.M. Kuo Physiological levels of tea catechins increase cellular lipid antioxidant activity of vitamin C and vitamin E in human intestinal caco-2 cells Chem. Biol. Interact. 169 2007 91 99
43. M. Galleano, S.V. Verstraeten, P.I. Oteiza, and C.G. Fraga Antioxidant actions of flavonoids: thermodynamic and kinetic analysis Arch. Biochem. Biophys. 501 2010 23 30
44. A. Izcue, S. Hue, S. Buonocore, C.V. Arancibia-Cárcamo, P.P. Ahern, Y. Iwakura, K.J. Maloy, and F. Powrie Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis Immunity 28 2008 559 570
45. S. Hue, P. Ahern, S. Buonocore, M.C. Kullberg, D.J. Cua, B.S. McKenzie, F. Powrie, and K.J. Maloy Interleukin-23 drives innate and T cell-mediated intestinal inflammation J. Exp. Med. 203 2006 2473 2483
46. F. Sanchez-Munoz, A. Dominguez-Lopez, and J.K. Yamamoto-Furusho Role of cytokines in inflammatory bowel disease World J. Gastroenterol. 14 2008 4280 4288
47. Henderson, P., van Limbergen, J.E., Schwarze, J., Wilson, D.C., in press. Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease. Inflamm. Bowel Dis. doi:10.1002/ibd.21379.
48. C.G. Fraga Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions IUBMB Life 59 2007 308 315