Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3

Journal of Clinical Neuroscience

Volumn 18, Issue 1, 2011, Pages 96-99

  Shen, Jun ^a,b   Li, Chao Ding ^a   Yang, Hui Lin ^a   Lu, Jian ^a   Zou, Tian Ming ^b   Wang, Dong Lai ^b   Deng, Min ^a  

^a SOOCHOW UNIVERSITY   (China)

^b SUZHOU MUNICIPAL HOSPITAL   (China)

Author keywords

Brachyury; Chordoma; Galectin 3; Immunohistochemistry; Notochordal cell

Indexed keywords

GALECTIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRACHYURY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL TYPE; CHORDOMA; CLINICAL ARTICLE; EXTRACELLULAR MATRIX; HUMAN; HUMAN TISSUE; MALIGNANT TRANSFORMATION; NOTOCHORD; NOTOCHORDAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ADULT; AGED; CHORDOMA; FETAL PROTEINS; GALECTIN 3; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NOTOCHORD; SPINAL NEOPLASMS; T-BOX DOMAIN PROTEINS;

EID: 78650171636     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2010.03.066     Document Type: Article

References (21)

1. S. Romeo, and P.C. Hogendoorn Brachyury and chordoma: the chondroid-chordoid dilemma resolved J Pathol 209 2006 143 146 (Pubitemid 43805408)
2. T. Yamaguchi, S. Suzuki, and H. Ishiiwa Benign notochordal cell tumors: a comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs Am J Surg Pathol 28 2004 756 761 (Pubitemid 38685889)
3. T. Naka, Y. Iwamoto, and N. Shinohara Cytokeratin subtyping in chordomas and the fetal notochord: an immunohistochemical analysis of aberrant expression Mod Pathol 10 1997 545 551 (Pubitemid 27293492)
4. S. Vujovic, S. Henderson, and N. Presneau Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas J Pathol 209 2006 157 165 (Pubitemid 43805410)
5. T. Yamaguchi, S. Suzuki, and H. Ishiiwa Intraosseous benign notochordal cell tumours: overlooked precursors of classic chordomas Histopathology 44 2004 597 602 (Pubitemid 38845106)
6. T. Yamaguchi, H. Watanabe-Ishiiwa, and S. Suzuki Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors Mod Pathol 18 2005 1005 1010 (Pubitemid 41059964)
7. T. Yamaguchi, M. Yamato, and K. Saotome First histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion: differential diagnosis of benign and malignant notochordal lesions Skeletal Radiol 31 2002 413 418 (Pubitemid 36067537)
8. V. Deshpande, G.P. Nielsen, and D.I. Rosenthal Intraosseous benign notochord cell tumors (BNCT): further evidence supporting a relationship to chordoma Am J Surg Pathol 31 2007 1573 1577 (Pubitemid 47482472)
9. E. Oguz, T.T. Tsai, and M.A. Di Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype Spine 32 2007 9 16 (Pubitemid 46058578)
10. S.F. Juliao, N. Rand, and H.S. Schwartz Galectin-3: a biologic marker and diagnostic aid for chordoma Clin Orthop Relat Res 2002 70 75 (Pubitemid 34442017)
11. H. Muller Ueber das Vorkommen von Resten der Chorda dorsalis bei Menschen nach der Geburt und über ihr Verhältniss zu den Gallertgeschwü lsten am Clivus Z Rationelle Med 2 1858 202 229
12. T. Horwitz Chordal ectopia and its possible relation to chordoma Arch Pathol 31 1941 354 362
13. K.S. Choi, M.J. Cohn, and B.D. Harfe Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation Dev Dyn 237 2008 3953 3958
14. H.D. Dorfman, and B. Czerniak Bone tumors 1998 C.V. Mosby St. Louis, Missouri, USA p. 974-1008
15. J.M. Mirra, and E.W. Brien Giant notochordal hamartoma of intraosseous origin: a newly reported benign entity to be distinguished from chordoma. Report of two cases Skeletal Radiol 30 2001 698 709 (Pubitemid 33138704)
16. C. Showell, O. Binder, and F.L. Conlon T-box genes in early embryogenesis Dev Dyn 229 2004 201 218 (Pubitemid 38036834)
17. B.G. Herrmann, S. Labeit, and A. Poustka Cloning of the T gene required in mesoderm formation in the mouse Nature 343 1990 617 622
18. G.J. Oakley, K. Fuhrer, and R.R. Seethala Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis Mod Pathol 21 2008 1461 1469
19. W. Gotz, M. Kasper, and N. Miosge Detection and distribution of the carbohydrate binding protein galectin-3 in human notochord, intervertebral disc and chordoma Differentiation 62 1997 149 157 (Pubitemid 28014716)
20. K. Lapis, and J. Timar Role of elastin-matrix interactions in tumor progression Semin Cancer Biol 12 2002 209 217 (Pubitemid 34833064)
21. Y. Zeng, K.G. Danielson, and T.J. Albert HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc J Bone Miner Res 22 2007 1851 1861 (Pubitemid 351229301)