The safety of opioid analgesics in the elderly: New data raise new concerns

Archives of Internal Medicine

Volumn 170, Issue 22, 2010, Pages 1986-1988

  Becker, William C ^a   O'Connor, Patrick G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; DEXTROPROPOXYPHENE; HYDROCODONE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; OXYCODONE; TRAMADOL;

AGED; ANALGESIA; ARTHRITIS; CARDIOVASCULAR RISK; DRUG MISUSE; DRUG OVERDOSE; DRUG TRAFFIC; FALLING; FRACTURE; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GERIATRIC PATIENT; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HUMAN; NOTE; OPIATE ADDICTION; PAIN; PATIENT EDUCATION; PATIENT MONITORING; PRESCRIPTION; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT INDICATION;

AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARDIOVASCULAR DISEASES; COMORBIDITY; CYCLOOXYGENASE 2 INHIBITORS; DRUG UTILIZATION; FEMALE; FRACTURES, BONE; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; MEDICARE; OBSERVATION; PAIN; PAIN MEASUREMENT; RESEARCH DESIGN; THERAPEUTIC EQUIVALENCY; UNITED STATES;

EID: 78650164996     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinternmed.2010.443     Document Type: Note

References (13)

1. Drug Enforcement Administration. Retail drug summary. 2010. http://www.deadiversion.usdoj.gov/arcos/retail-drug-summary/. Accessed July 12, 2010.
2. Paulozzi LJ, Budnitz DS, Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol Drug Saf. 2006;15(9):618-627. (Pubitemid 44404658)
3. McLellan AT, Turner BJ. Chronic noncancer pain management and opioid overdose: time to change prescribing practices. Ann Intern Med. 2010;152(2):123-124.
4. Katz MH. Long-term opioid treatment of nonmalignant pain: a believer loses his faith. Arch Intern Med. 2010;170(16):1422-1424.
5. Chou R, Fanciullo GJ, Fine PG, et al; American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113-130.
6. Becker WC, Sullivan LE, Tetrault JM, Desai RA, Fiellin DA. Non-medical use, abuse and dependence on prescription opioids among U.S. adults: psychiatric, medical and substance use correlates. Drug Alcohol Depend. 2008;94(1-3):38-47.
7. Pergolizzi J, Böger RH, Budd K, et al. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone). Pain Pract. 2008;8(4):287-313.
8. Solomon DH, Rassen JA, Glynn RJ, Lee J, Levin R, Schneeweiss S. The comparative safety of analgesics in older adults with arthritis. Arch Intern Med. 2010;170(22):1968-1978.
9. Slone Epidemiology Center at Boston University. Patterns of medication use in the United States, 2006: a report from the Slone Survey. 2006. http://www.bu.edu/slone/SloneSurvey/AnnualRpt/SloneSurveyWebReport2006.pdf. Accessed September 20, 2010.
10. American College of Rheumatology Ad Hoc Group on Use of Selective and Nonselective Nonsteroidal Antiinflammatory Drugs. Recommendations for use of selective and nonselective nonsteroidal antiinflammatory drugs: an American College of Rheumatology white paper [published correction appears in Arthritis Rheum. 2008;59(11):1686]. Arthritis Rheum. 2008;59(8):1058-1073.
11. Katz N, Mazer NA. The impact of opioids on the endocrine system. Clin J Pain. 2009;25(2):170-175.
12. Tinetti ME. Clinical practice: preventing falls in elderly persons. N Engl J Med. 2003;348(1):42-49. (Pubitemid 36026346)
13. Chou R, Ballantyne JC, Fanciullo GJ, Fine PG,Miaskowski C. Research gaps on use of opioids for chronic noncancer pain: findings from a review of the evidence for an American Pain Society and American Academy of Pain Medicine clinical practice guideline. J Pain. 2009;10(2):147-159.