Interaction study on garlic and atorvastatin with reference to nephrotoxicity in dyslipidaemic rats

Toxicology International

Volumn 17, Issue 2, 2010, Pages 90-93

  Reddy, G Dilip ^a   Reddy, A Gopala ^a   Rao, G Srinivasa ^b   Haritha, C ^a   Jyothi, K ^a  

^a Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go Anusandhan Sansthan   (India)

^b NTR College of Veterinary Science   (India)

Author keywords

Atorvastatin; garlic; kidney

Indexed keywords

ATORVASTATIN; CREATININE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; BOWMAN CAPSULE; CHOLESTEROL DIET; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DYSLIPIDEMIA; ELECTRON MICROSCOPY; GARLIC; LIPID DIET; LIPID STORAGE; MALE; NEPHROTOXICITY; NONHUMAN; RAT;

ALLIUM SATIVUM; RATTUS;

EID: 78650160144     PISSN: 09716580     EISSN: None     Source Type: Journal    
DOI: 10.4103/0971-6580.72678     Document Type: Article

References (14)

1. Mahley RW, Bersot TP. Drug therapy for hypercholesterolemia and dyslipidemia. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11 th ed. NewYork: McGraw Hill; 2006. p. 933-60.
2. Malhotra HS, Goa KL. Atorvastatin: An updated review of its pharmacological properties and use in dyslipidaemia. Drug evaluation. Drugs 2001;61:1835-81.
3. Alaupovic P, Heinonen T, Shurzinske L, Black DM. Effect of a new HMG-CoA reductase inhibitor, atorvastatin, on lipids, apolipoproteins and lipoprotein particles in patients with elevated serum cholesterol and triglyceride levels. Atherosclerosis 1997;133:123-33.
4. Dubey NK, Kumar R, Tripathi P. Global promotion of herbal medicine: India's opportunity. Curr Sci 2004;86:37-41.
5. Lau BH, Adetumbi MA, Sanchez A. Allium sativum (garlic) and atherosclerosis: A review. Nutr Res 1983;3:119-28.
6. Chi MS, Koh ET, Stewartt AJ. Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J Nutr 1982;112:241-8.
7. Jani A, Mehta A. Pharmacology of Allium sativum in relation to Cytochrome P450 and possible drug interactions. Pharmacogn Rev 2007;2:222-6.
8. Balasubramanian KA, Manohar M, Mathan VI. An unidentified inhibitor of lipid peroxidation in intestinal mucosa. Biochim Biophys Acta 1988;962:51-8.
9. Culling CF. Handbook of Histopathological and Histochemical Techniques. 3 rd ed. London, U.K.: Butterworths and Co.; 1974.
10. Bozzola JJ, Russell LD. Electron microscopy: Principles and techniques for biologists. 2 nd ed. Boston: Jones and Bartlett; 1999.
11. Kaneko JJ, Harvey JW, Michael LB. Clinical Biochemistry of Domestic Animals. 5 th ed. New York: Academic press; 1997. p. 182-9, 857-79.
12. Foster BC, Foster MS, Vandenhoek S, Krantis A, Budzinski JW, Arnason JT, et al. An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. J Pharm Pharmaceutical Sci 2001;4:159-67.
13. Pedraza-Chaverri J, Yam-Canul P, Chirino YI, Snchez-Gonzlez DJ, Martnez-Martnez CM, Cruz C, et al. Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity. Food Chem Toxicol 2008;46:619-27.
14. Segoviano-Murillo S, Snchez-Gonzlez DJ, Martnez-Martnez CM, Cruz C, Maldonado PD, Pedraza-Chaverr J. S-allylcysteine ameliorates ischemia and reperfusion induced renal damage. Phytother Res 2007;22:836-40.