Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease

Inflammatory Bowel Diseases

Volumn 17, Issue 1, 2011, Pages 251-259

  Agarwal, Shradha ^a   Smereka, Paul ^a   Harpaz, Noam ^a   Cunningham Rundles, Charlotte ^a   Mayer, Lloyd ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

antibody deficiency; common variable immunodeficiency; gastrointestinal disease; inflammatory bowel disease

Indexed keywords

CD28 ANTIGEN; CD3 ANTIBODY; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INFLIXIMAB; INTERLEUKIN 10; INTERLEUKIN 2; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ANTIBODY;

ADULT; ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL STIMULATION; CLINICAL ARTICLE; COLON; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; IMMUNOHISTOCHEMISTRY; INTESTINE; INTESTINE BIOPSY; INTESTINE MUCOSA; LAMINA PROPRIA; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; MORPHOMETRICS; PERIPHERAL LYMPHOCYTE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; ULCERATIVE COLITIS;

COLITIS, ULCERATIVE; COMMON VARIABLE IMMUNODEFICIENCY; CROHN DISEASE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINAL DISEASES; T-LYMPHOCYTES;

EID: 78650159721     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21376     Document Type: Article

References (30)

1. Bonilla FA, Bernstein IL, Khan DA, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 2005; 94: S1-63.
2. Cunningham-Rundles C, Kasbay K, Mayer L,. Potential uses of polyethylene glycol conjugated recombinant IL-2 in common variable immunodeficiency. Immunodeficiency. 1993; 4: 31-36.
3. Kruger G, Welte K, Ciobanu N, et al. Interleukin-2 correction of defective in vitro T-cell mitogenesis in patients with common varied immunodeficiency. J Clin Immunol. 1984; 4: 295-303.
4. Lopez-Botet M, Fontan G, Garcia Rodriguez MC, et al. Relationship between IL 2 synthesis and the proliferative response to PHA in different primary immunodeficiencies. J Immunol. 1982; 128: 679-683.
5. Spickett GP, Farrant J,. The role of lymphokines in common variable hypogammaglobulinemia. Immunol Today. 1989; 10: 192-194.
6. Washington K, Stenzel TT, Buckley RH, et al. Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. Am J Surg Pathol. 1996; 20: 1240-1252.
7. Kalha I, Sellin JH,. Common variable immunodeficiency and the gastrointestinal tract. Curr Gastroenterol Rep. 2004; 6: 377-383.
8. Hermans PE, Diaz-Buxo JA, Stobo JD,. Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients. Am J Med. 1976; 61: 221-237.
9. Hermaszewski RA, Webster AD,. Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med. 1993; 86: 31-42.
10. Cunningham-Rundles C, Bodian C,. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999; 92: 34-48.
11. Quinti I, Soresina A, Spadaro G, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007; 27: 308-316.
12. Atarod L, Raissi A, Aghamohammadi A, et al. A review of gastrointestinal disorders in patients with primary antibody immunodeficiencies during a 10-year period (1990-2000), in children hospital medical center. Iran J Allergy Asthma Immunol. 2003; 2: 75-79.
13. Wood P, Stanworth S, Burton J, et al. Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review. Clin Exp Immunol. 2007; 149: 410-423.
14. Khodadad A, Aghamohammadi A, Parvaneh N, et al. Gastrointestinal manifestations in patients with common variable immunodeficiency. Dig Dis Sci. 2007; 52: 2977-2983. (Pubitemid 47512541)
15. Mannon PJ, Fuss IJ, Dill S, et al. Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology. 2006; 131: 748-756.
16. Luzi G, Zullo A, Iebba F, et al. Duodenal pathology and clinical-immunological implications in common variable immunodeficiency patients. Am J Gastroenterol. 2003; 98: 118-121.
17. Teahon K, Webster AD, Price AB, et al. Studies on the enteropathy associated with primary hypogammaglobulinaemia. Gut. 1994; 35: 1244-1249.
18. Twomey JJ, Jordan PH, Jarrold T, et al. The syndrome of immunoglobulin deficiency and pernicious anemia. A study of ten cases. Am J Med. 1969; 47: 340-350.
19. Fischer MB, Hauber I, Eggenbauer H, et al. Activation of CVID patients' T cells with conventional antigens and superantigens. Immunodeficiency. 1993; 4: 15-16.
20. Fischer MB, Hauber I, Eggenbauer H, et al. A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency. Blood. 1994; 84: 4234-4241.
21. Jaffe JS, Eisenstein E, Sneller MC, et al. T-cell abnormalities in common variable immunodeficiency. Pediatr Res. 1993; 33: S24-27; discussion S7-8.
22. North ME, Webster AD, Farrant J,. Defects in proliferative responses of T cells from patients with common variable immunodeficiency on direct activation of protein kinase C. Clin Exp Immunol. 1991; 85: 198-201.
23. Stagg AJ, Funauchi M, Knight SC, et al. Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol. 1994; 96: 48-53.
24. Bayry J, Lacroix-Desmazes S, Kazatchkine MD, et al. Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood. 2004; 104: 2441-2443.
25. Cambronero R, Sewell WA, North ME, et al. Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. J Immunol. 2000; 164: 488-494.
26. Cunningham-Rundles C, Radigan L,. Deficient IL-12 and dendritic cell function in common variable immune deficiency. Clin Immunol. 2005; 115: 147-153.
27. Scott-Taylor TH, Green MR, Eren E, et al. Monocyte derived dendritic cell responses in common variable immunodeficiency. Clin Exp Immunol. 2004; 138: 484-490.
28. Oksenhendler E, Gerard L, Fieschi C, et al. Infections in 252 patients with common variable immunodeficiency. Clin Infect Dis. 2008; 46: 1547-1554.
29. Geha RS, Notarangelo LD, Casanova JL, et al. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol. 2007; 120: 776-794.
30. Mayer L, Posnett DN, Kunkel HG,. Human malignant T cells capable of inducing an immunoglobulin class switch. J Exp Med. 1985; 161: 134-144.