α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectors

Human Gene Therapy

Volumn 21, Issue 12, 2010, Pages 1657-1664

  Zhang, Liqun ^a   Limberis, Maria P ^b   Thompson, Catherine ^a   Antunes, Marcelo B ^b   Luongo, Cindy ^c   Wilson, James M ^b   Collins, Peter L ^c   Pickles, Raymond J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PARAINFLUENZA VIRUS VECTOR; RANTES; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; NASAL LAVAGE; NONHUMAN; PARAINFLUENZA VIRUS; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; RHESUS MONKEY; TRANSGENE; TRANSIENT EXPRESSION; VIRAL GENE DELIVERY SYSTEM; VIRUS REPLICATION;

ALPHA-FETOPROTEINS; ANIMALS; CELLS, CULTURED; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; MACACA MULATTA; NASAL MUCOSA; PARAINFLUENZA VIRUS 3, HUMAN; RECOMBINANT PROTEINS; VIRAL LOAD; VIRUS REPLICATION;

MACACA MULATTA; PARAINFLUENZA VIRUS; PRIMATES;

EID: 78650141161     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2010.065     Document Type: Article

References (20)

1. Ball, D., Rose, E., and Alpert, E. (1992). a-Fetoprotein levels in normal adults. Am. J. Med. Sci. 303, 157-159.
2. Ban, H., Inoue, M., Griesenbach, U., Munkonge, F., Chan, M., Iida, A., Alton, E.W., and Hasegawa, M. (2007). Expression and maturation of Sendai virus vector-derived CFTR protein: Functional and biochemical evidence using a GFP-CFTR fusion protein. Gene Ther. 14, 1688-1694. (Pubitemid 350238445)
3. Boucher, R.C., Knowles, M.R., Johnson, L.G., Olsen, J.C., Pickles, R., Wilson, J.M., Engelhardt, J., Yang, Y., and Grossman, M. (1994). Gene therapy for cystic fibrosis using E1-deleted ade-novirus: A phase I trial in the nasal cavity. Hum. Gene Ther. 5, 615-639.
4. Durbin, A.P., Hall, S.L., Siew, J.W., Whitehead, S.S., Collins, P.L., and Murphy, B.R. (1997). Recovery of infectious human parainfluenza virus type 3 from cDNA. Virology 235, 323-332. (Pubitemid 27394345)
5. Ferrari, S., Griesenbach, U., Iida, A., Farley, R., Wright, A.M., Zhu, J., Munkonge, F.M., Smith, S.N., You, J., Ban, H., Inoue, M., Chan, M., Singh, C., Verdon, B., Argent, B.E., Wainwright, B., Jeffery, P.K., Geddes, D.M., Porteous, D.J., Hyde, S.C., Gray, M.A., Hasegawa, M., and Alton, E.W. (2007). Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Ther. 14, 1371-1379. (Pubitemid 47423736)
6. Flotte, T.R., Zeitlin, P.L., Reynolds, T.C., Heald, A.E., Pedersen, P., Beck, S., Conrad, C.K., Brass-Ernst, L., Humphries, M., Sullivan, K., Wetzel, R., Taylor, G., Carter, B.J., and Guggino, W.B. (2003). Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus sero-type 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: A two-part clinical study. Hum. Gene Ther. 14, 1079-1088. (Pubitemid 36851399)
7. Fulcher, M.L., Gabriel, S., Burns, K.A., Yankaskas, J.R., and Randell, S.H. (2005). Well-differentiated human airway epithelial cell cultures. Methods Mol. Med. 107, 183-206.
8. Karron, R.A., and Collins, P.L. (2006). Parainfluenza viruses. (Lippincott Williams & Wilkins, Philadelphia, PA).
9. Klink, D., Schindelhauer, D., Laner, A., Tucker, T., Bebok, Z., Schwiebert, E.M., Boyd, A.C., and Scholte, B.J. (2004). Gene delivery systems-gene therapy vectors for cystic fibrosis. J. Cyst. Fibros. 3(Suppl. 2), 203-212. (Pubitemid 40045599)
10. Knowles, M., Gatzy, J., and Boucher, R. (1981). Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N. Engl. J. Med. 305, 1489-1495. (Pubitemid 12244203)
11. Kreda, S.M., Mall, M., Mengos, A., Rochelle, L., Yankaskas, J., Riordan, J.R., and Boucher, R.C. (2005). Characterization of wild-type and DF508 cystic fibrosis transmembrane regulator in human respiratory epithelia. Mol. Biol. Cell 16, 2154-2167. (Pubitemid 40632202)
12. Mizejewski, G.J. (2001). a-Fetoprotein structure and function: Relevance to isoforms, epitopes, and conformational variants. Exp. Biol. Med. (Maywood) 226, 377-408. (Pubitemid 32506364)
13. Murphy, B.R., and Collins, P.L. (2002). Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: Applications of reverse genetics. J. Clin. Invest. 110, 21-27. (Pubitemid 34743460)
14. O'Neal, W.K., Rose, E., Zhou, H., Langston, C., Rice, K., Carey, D., and Beaudet, A.L. (2000). Multiple advantages of a-fetoprotein as a marker for in vivo gene transfer. Mol. Ther. 2, 640-648.
15. Roxo-Rosa, M., Da Costa, G., Luider, T.M., Scholte, B.J., Coelho, A.V., Amaral, M.D., and Penque, D. (2006). Proteomic analysis of nasal cells from cystic fibrosis patients and non-cystic fibrosis control individuals: Search for novel biomarkers of cystic fibrosis lung disease. Proteomics 6, 2314-2325.
16. Skiadopoulos, M.H., Surman, S.R., Durbin, A.P., Collins, P.L., and Murphy, B.R. (2000). Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes. Virology 272, 225-234. (Pubitemid 30429446)
17. Skiadopoulos, M.H., Surman, S.R., Riggs, J.M., Orvell, C., Collins, P.L., and Murphy, B.R. (2002). Evaluation of the replication and immunogenicity of recombinant human parainfluenza virus type 3 vectors expressing up to three foreign glycoproteins. Virology 297, 136-152. (Pubitemid 34734918)
18. Tate, S., and Elborn, S. (2005). Progress towards gene therapy for cystic fibrosis. Expert Opin. Drug Deliv. 2, 269-280. (Pubitemid 41130882)
19. Zhang, L., Bukreyev, A., Thompson, C.I., Watson, B., Peeples, M.E., Collins, P.L., and Pickles, R.J. (2005). Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. J. Virol. 79, 1113-1124. (Pubitemid 40053894)
20. Zhang, L., Button, B., Gabriel, S.E., Burkett, S., Yan, Y., Skiadopoulos, M.H., Dang, Y.L., Vogel, L.N., McKay, T., Mengos, A., Boucher, R.C., Collins, P.L., and Pickles, R.J. (2009). CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium. PLoS Biol. 7, e1000155.