Serum antibody levels to the Pneumocystis jirovecii major surface glycoprotein in the diagnosis of P. jirovecii pneumonia in HIV+ patients

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Djawe, Kpandja ^a,b   Huang, Laurence ^c   Daly, Kieran R ^a,b   Levin, Linda ^b   Koch, Judy ^a,b   Schwartzman, Alexandra ^c   Fong, Serena ^c   Roth, Brenna ^c   Subramanian, Anuradha ^c   Grieco, Katherine ^c   Jarlsberg, Leah ^c   Walzer, Peter D ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTATE DEHYDROGENASE; PNEUMOCYSTIS JIROVECI MAJOR SURFACE GLYCOPROTEIN RECOMBINANT FRAGMENT C1; UNCLASSIFIED DRUG; MEMBRANE PROTEIN;

ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LACTATE DEHYDROGENASE BLOOD LEVEL; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PNEUMOCYSTIS JIROVECI; PNEUMOCYSTIS PNEUMONIA; PNEUMONIA; SENSITIVITY AND SPECIFICITY; CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG LAVAGE; METABOLISM; METHODOLOGY; MICROBIOLOGY; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE; VIROLOGY;

PNEUMOCYSTIS; PNEUMOCYSTIS JIROVECII;

BRONCHOALVEOLAR LAVAGE FLUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIV INFECTIONS; HIV SEROPOSITIVITY; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MEMBRANE GLYCOPROTEINS; MULTIVARIATE ANALYSIS; PNEUMOCYSTIS JIROVECII; PNEUMONIA, PNEUMOCYSTIS; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY;

EID: 78650139624     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014259     Document Type: Article

References (47)

1. Morris A, Lundgren JD, Masur H, Walzer PD, Hanson DL, et al. (2004) Current epidemiology of Pneumocystis pneumonia. Emerg Infect Dis 10: 1713-1720.
2. Krajicek BJ, Thomas CF, Jr., Limper AH (2009) Pneumocystis pneumonia: current concepts in pathogenesis, diagnosis, and treatment. Clin Chest Med 30: 265-278, vi.
3. Walzer PD, Evans HE, Copas AJ, Edwards SG, Grant AD, et al. (2008) Early predictors of mortality from Pneumocystis jirovecii pneumonia in HIV-infected patients: 1985-2006. Clin Infect Dis 46: 625-633.
4. Thomas CF, Jr., Limper AH (2004) Pneumocystis pneumonia. N Engl J Med 350: 2487-2498.
5. Rimland D, Navin TR, Lennox JL, Jernigan JA, Kaplan J, et al. (2002) Prospective study of etiologic agents of community-acquired pneumonia in patients with HIV infection. AIDS 16: 85-95.
6. Tasaka S, Hasegawa N, Kobayashi S, Yamada W, Nishimura T, et al. (2007) Serum indicators for the diagnosis of pneumocystis pneumonia. Chest 131: 1173-1180.
7. Selwyn PA, Pumerantz AS, Durante A, Alcabes PG, Gourevitch MN, et al. (1998) Clinical predictors of Pneumocystis carinii pneumonia, bacterial pneumonia and tuberculosis in HIV-infected patients. AIDS 12: 885-893.
8. Watanabe T, Yasuoka A, Tanuma J, Yazaki H, Honda H, et al. (2009) Serum (1R3) beta-D-glucan as a noninvasive adjunct marker for the diagnosis of Pneumocystis pneumonia in patients with AIDS. Clin Infect Dis 49: 1128-1131.
9. Pisculli ML, Sax PE (2008) Use of a serum beta-glucan assay for diagnosis of HIV-related Pneumocystis jiroveci pneumonia in patients with negative microscopic examination results. Clin Infect Dis 46: 1928-1930.
10. Davis JL, Welsh DA, Beard CB, Jones JL, Lawrence GG, et al. (2008) Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia. Thorax 63: 329-334.
11. Peglow SL, Smulian AG, Linke MJ, Pogue CL, Nurre S, et al. (1990) Serologic responses to Pneumocystis carinii antigens in health and disease. J Infect Dis 161: 296-306.
12. Burns SM, Read JA, Yap PL, Brettle RP (1990) Reduced concentrations of IgG antibodies to Pneumocystis carinii in HIV-infected patients during active Pneumocystis carinii infection and the possibility of passive immunisation. J Infect 20: 33-39.
13. Hofmann B, Odum N, Platz P, Ryder LP, Svejgaard A, et al. (1985) Humoral responses to Pneumocystis carinii in patients with acquired immunodeficiency syndrome and in immunocompromised homosexual men. J Infect Dis 152: 838-840.
14. Elvin K, Bjorkman A, Heurlin N, Eriksson BM, Barkholt L, et al. (1994) Seroreactivity to Pneumocystis carinii in patients with AIDS versus other immunosuppressed patients. Scand J Infect Dis 26: 33-40.
15. Laursen AL, Andersen PL (1998) Low levels of IgG antibodies against pneumocystis carinii among HIV-infected patients. Scand J Infect Dis 30: 495-499.
16. Lundgren B, Kovacs JA, Mathiesen L, Nielsen JO, Lundgren JD (1993) IgM response to a human Pneumocystis carinii surface antigen in HIV-infected patients with pulmonary symptoms. Scand J Infect Dis 25: 515-520.
17. Pifer LL, Niell HB, Langdon SB, Baltz S, Clark ST, et al. (1987) Evidence for depressed humoral immunity to Pneumocystis carinii in homosexual males, commercial plasma donors, and patients with acquired immunodeficiency syndrome. J Clin Microbiol 25: 991-995.
18. Lundgren B, Lundgren JD, Nielsen T, Mathiesen L, Nielsen JO, et al. (1992) Antibody responses to a major Pneumocystis carinii antigen in human immunodeficiency virus-infected patients with and without P. carinii pneumonia. J Infect Dis 165: 1151-1155.
19. Walzer PD (1999) Immunological features of Pneumocystis carinii infection in humans. Clin Diagn Lab Immunol 6: 149-155.
20. Garbe TR, Stringer JR (1994) Molecular characterization of clustered variants of genes encoding major surface antigens of human Pneumocystis carinii. Infect Immun 62: 3092-3101.
21. Kutty G, Kovacs JA (2003) A single-copy gene encodes Kex1, a serine endoprotease of Pneumocystis jiroveci. Infect Immun 71: 571-574.
22. Kovacs JA, Powell F, Edman JC, Lundgren B, Martinez A, et al. (1993) Multiple genes encode the major surface glycoprotein of Pneumocystis carinii. J Biol Chem 268: 6034-6040.
23. Stringer JR, Keely SP (2001) Genetics of surface antigen expression in Pneumocystis carinii. Infect Immun 69: 627-639.
24. Daly KR, Fichtenbaum CJ, Tanaka R, Linke MJ, O'Bert R, et al. (2002) Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons. J Infect Dis 186: 644-651.
25. Daly KR, Koch J, Levin L, Walzer PD (2004) Enzyme-linked immunosorbent assay and serologic responses to Pneumocystis jiroveci. Emerg Infect Dis 10: 848-854.
26. Daly KR, Koch JV, Shire NJ, Levin L, Walzer PD (2006) Human immunodeficiency virus-infected patients with prior Pneumocystis pneumonia exhibit increased serologic reactivity to several major surface glycoprotein clones. Clin Vaccine Immunol 13: 1071-1078.
27. Tipirneni R, Daly KR, Jarlsberg LG, Koch JV, Swartzman A, et al. (2009) Healthcare worker occupation and immune response to Pneumocystis jirovecii. Emerg Infect Dis 15: 1590-1597.
28. Daly K, Koch J, Respaldiza N, de la Horra C, Montes-Cano MA, et al. (2009) Geographical variation in serological responses to recombinant Pneumocystis jirovecii major surface glycoprotein antigens. Clin Microbiol Infect 15: 937-942.
29. Djawe K, Daly KR, Vargas SL, Santolaya S, Ponce CA, et al. (2010) Seroepidemiological Study of Pneumocystis Jirovecii infection in healthy infants in Chile using recombinant fragments of the P. jirovecii major surface glycoprotein. Internat J Infect Dis, (in press).
30. Nkinin SW, Daly KR, Walzer PD, Ndzi ES, Asonganyi T, et al. (2009) Evidence for high prevalence of Pneumocystis jirovecii exposure among Cameroonians. Acta Trop 112: 219-224.
31. Walzer PD, Djawe K, Levin L, Daly KR, Koch J, et al. (2009) Long-term serologic responses to the Pneumocystis jirovecii major surface glycoprotein in HIV-positive individuals with and without P. jirovecii infection. J Infect Dis 199: 1335-1344.
32. Daly KR, Huang L, Morris A, Koch J, Crothers K, et al. (2006) Antibody response to Pneumocystis jirovecii major surface glycoprotein. Emerg Infect Dis 12: 1231-1237.
33. Huang L, Hecht FM, Stansell JD, Montanti R, Handley WK, et al. (1995) Suspected Pneumocystis Carinii pneumonia with a negative induced sputum examination. Is early bronchoscopy useful? Am J Respir Crit Care Med 151(6): 1866-1871.
34. Bishop LR, Kovacs JA (2003) Quantitation of anti-Pneumocystis jiroveci antibodies in healthy persons and immunocompromised patients. J Infect Dis 187: 1844-1848.
35. Goldenberg DM, Sharkey RM, Udem S, Vagg R, Levine GM, et al. (1994) Immunoscintigraphy of Pneumocystis carinii pneumonia in AIDS patients. J Nud Med 35(6): 1034-7.
36. Cagigi A, Nilsson A, De Milito A, Chiodi F (2008) B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design. Vaccine 26: 3016-3025.
37. De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, et al. (2004) Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection. Blood 103: 2180-2186.
38. Kroon FP, van Dissel JT, Rijkers GT, Labadie J, van Furth R (1997) Antibody response to Haemophilus influenzae type b vaccine in relation to the number of CD4+ T lymphocytes in adults infected with human immunodeficiency virus. Clin Infect Dis 25: 600-606.
39. Singh MP, Dubey ML, Sud A, Malla N (2005) Antibody response to Toxoplasma gondii in saliva samples from human immunodeficiency virusinfected patients. Br J Biomed Sci 62: 81-84.
40. Keely SP, Stringer JR, Baughman RP, Linke MJ, Walzer PD, et al. (1995) Genetic variation among Pneumocystis carinii hominis isolates in recurrent pneumocystosis. J Infect Dis 172: 595-598.
41. Stansell JD, Osmond DH, Charlebois E, LaVange L, Wallace JM, et al. (1997) Predictors of Pneumocystis carinii pneumonia in HIV-infected persons. Pulmonary Complications of HIV Infection Study Group. Am J Respir Crit Care Med 155: 60-66.
42. Kaplan JE, Hanson DL, Navin TR, Jones JL (1998) Risk factors for primary Pneumocystis carinii pneumonia in human immunodeficiency virus-infected adolescents and adults in the United States: reassessment of indications for chemoprophylaxis. J Infect Dis 178: 1126-1132.
43. Forthal DN, Landucci G, Bream J, Jacobson LP, Phan TB, et al. (2007) FcgammaRIIa genotype predicts progression of HIV infection. J Immunol 179: 7916-7923.
44. Duggal P, An P, Beaty TH, Strathdee SA, Farzadegan H, et al. (2003) Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African Americans. Genes Immun 4: 245-250.
45. Morrow BM, Hsaio NY, Zampoli M, Whitelaw A, Zar HJ (2010) Pneumocystis Pneumonia in South African Children With and Without Human Immunodeficiency Virus Infection in the Era of Highly Active Antiretroviral Therapy. Pediatr Infect Dis J.
46. Morris A, Netravali M, Kling HM, Shipley T, Ross T, et al. (2008) Relationship of pneumocystis antibody response to severity of chronic obstructive pulmonary disease. Clin Infect Dis 47: e64-68.
47. Choukri F, Menotti J, Sarfati C, Lucet JC, Nevez G, et al. (2010) Quantification and spread of Pneumocystis jirovecii in the surrounding air of patients with Pneumocystis pneumonia. Clin Infect Dis 51(3): 266.