Microreactors for continuous processing - How close to commercial utility?

Current Opinion in Drug Discovery and Development

Volumn 13, Issue 6, 2010, Pages 642-644

  Fortunak, Joseph ^a   Confalone, Pat N ^b   Grosso, John A ^c  

^a HOWARD UNIVERSITY   (United States)

^b DUPONT COMPANY   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATCH PROCESS; BATCH REACTOR; CONTINUOUS PROCESS; DRUG MANUFACTURE; MICROREACTOR; PRODUCTIVITY; REACTOR; REVIEW;

CHEMISTRY, PHARMACEUTICAL; DRUG INDUSTRY; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 78650135445     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (7)

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2. Wirth T (Ed): Microreactors in Organic Synthesis and Catalysis. Wiley VCH, Weinheim, Germany (2008).
3. Doku GN, Verboom W, Reinhoudt DN, van den Berg A: On-microchip multiphase chemistry - A review of microreactor design principles and reagent contacting modes. Tetrahedron (2005) 61(11):2733-2742.
4. Roberge DM, Zimmermann B, Rainone F, Gottsponer M, Eyholzer M, Kockman N: Microreactor technology and continuous processing in the fne chemical and pharmaceutical industry: Is the revolution underway Org Process Res Dev (2008) 12(5):905-910.
5. Sotowa KI, Sugiyama S, Nakagawa K: Flow uniformity in deep microchannel reactor under high throughput conditions. Org Process Res Dev (2009) 13(5):1026-1031.
6. Hartman RL, Naber JR, Zaborenko N, Buchwald SL, Jensen KF: Overcoming the challenges of solid bridging and constriction during Pd-catalyzed C-N bond formation in microreactors. Org Process Res Dev (2010):doi:10.1021/op100154d
7. Roberge DM, Ducry L, Bieler N, Cretton P, Zimmerman B: Microreactor technology, a revolution for the fne chemical and pharmaceutical industries Chem Eng Technology (2005) 28(3):318-323.