Changes in glycoprotein IIb/IIIa inhibitor excess dosing with site-specific safety feedback in the can rapid risk stratification of Unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines (CRUSADE) initiative

American Heart Journal

Volumn 160, Issue 6, 2010, Pages 1072-1078

  Mudrick, Daniel W ^a   Chen, Anita Y ^a   Roe, Matthew T ^a   Newby, L Kristin ^a   Gibler, W Brian ^b   Ohman, E Magnus ^a   Peterson, Eric D ^a   Alexander, Karen P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; CREATININE; EPTIFIBATIDE; FIBRINOGEN RECEPTOR; TIROFIBAN;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLEEDING; CREATININE CLEARANCE; DRUG DOSE REDUCTION; DRUG SAFETY; FEEDBACK SYSTEM; FEMALE; GROUPS BY AGE; HEALTH PROGRAM; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PRACTICE GUIDELINE; PRIORITY JOURNAL; SEX DIFFERENCE; TREND STUDY; UNSTABLE ANGINA PECTORIS;

AGED; AGED, 80 AND OVER; ANGINA, UNSTABLE; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRACTICE GUIDELINES AS TOPIC; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 78650123866     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2010.08.008     Document Type: Article

References (31)

1. Anderson J.L., Adams C.D., and Antman E.M. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction Circulation 116 2007 e148 e304
2. Boersma E., Harrington R.A., and Moliterno D.J. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes Lancet 360 2002 342 343
3. Alexander K.P., Chen A.Y., and Roe M.T. Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes JAMA 294 2005 3108 3116
4. Alexander K.P., Chen A.Y., and Newby L.K. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE initiative Circulation 114 2006 1380 1387
5. Feit F., Voeltz M.D., and Attubato M.J. Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 trial Am J Cardiol 100 2007 1364 1369
6. Kinnaird T.D., Stabile E., and Mintz G.S. Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions Am J Cardiol 92 2003 930 935
7. Rao S.V., Jollis J.G., and Harrington R.A. Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes JAMA 292 2004 1555 1562
8. Yang X., Alexander K.P., and Chen A.Y. The implications of blood transfusions for patients with non-ST-segment elevation acute coronary syndromes: results from CRUSADE J Am Coll Cardiol 46 2005 1490 1495
9. Krumholz H.M., Anderson J.L., and Bachelder B.L. ACC/AHA 2008 performance measures for adults with ST-elevation and non-ST-elevation myocardial infarction Circulation 118 2008 2596 2648
10. Bhatt D.L., Roe M.T., and Peterson E.D. Utilization of early invasive management strategies for high-risk patients with non-ST-segment elevation acute coronary syndromes: results from CRUSADE JAMA 292 2004 2096 2104
11. Hoekstra J.W., Pollack C.V., and Roe M.T. Improving the care of patients with non-ST-elevation acute coronary syndromes in the emergency department: the CRUSADE initiative Acad Emerg Med 9 2002 1146 1155
12. Cockcroft D.W., and Gault M.H. Prediction of creatinine clearance from serum creatinine Nephron 16 1976 31 41
13. Integrilin (eptifibatide) package insert 2003 Millennium Pharmaceuticals, Inc South San Francisco, CA
14. Tirofiban package insert 2002 Merck and Co., Inc. Whitehouse Station, NJ
15. DeLong E.R., Peterson E.D., and DeLong D.M. Comparing risk-adjustment methods for provider profiling Stat Med 16 1997 2645 2664
16. Zeger S.L., and Liang K.Y. Longitudinal data analysis for discrete and continuous outcomes Biometrics 42 1986 121 130
17. Roe M.T., Chen A.Y., and Delong E.R. Patterns of transfer for patients with non-ST-segment elevation acute coronary syndrome from community to tertiary care hospitals Am Heart J 156 2008 185 192
18. Chen J., Radford M.J., and Wang Y. Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med 340 1999 286 292
19. Peterson E.D., Roe M.T., and Mulgund J. Association between hospital process performance and outcomes among patients with acute coronary syndromes JAMA 295 2006 1912 1920
20. Eagle K.A., Montoye C.K., and Riba A.L. Guideline-based standardized care is associated with substantially lower mortality in Medicare patients with acute myocardial infarction: the ACC's GAP projects in Michigan J Am Coll Cardiol 46 2005 1242 1248
21. Fonarow G.C., Gawlinski A., and Moughrabi S. Improved treatment of coronary heart disease by implementation of a Cardiac Hospitalization Atherosclerosis Management Program Am J Cardiol 87 2001 819 822
22. Lappe J.M., Muhlestein J.B., and Lappe D.L. Improvements in 1-year cardiovascular clinical outcomes associated with a hospital-based discharge medication program Ann Intern Med 141 2004 446 453
23. Huynh T., Piazza N., and DiBattiste P.M. Analysis of bleeding complications associated with glycoprotein IIb/IIIa receptors blockade in patients with high-risk acute coronary syndromes: insights from PRISM-PLUS Int J Cardiol 100 2005 73 78
24. Lenderink T., Boersma E., and Ruzyllo W. Bleeding events with abciximab in acute coronary syndromes without early revascularization: an analysis of GUSTO IV-ACS Am Heart J 147 2004 865 873
25. Subherwal S., Bach R.G., and Chen A.Y. Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE bleeding score Circulation 119 2009 1873 1882
26. Alexander K.P., Roe M.T., and Chen A.Y. Evolution in cardiovascular care for elderly patients with non-ST-segment elevation acute coronary syndromes: results from CRUSADE J Am Coll Cardiol 46 2005 1479 1487
27. Fernandes L.S., Tcheng J.E., and O'Shea J.C. Is glycoprotein IIb/IIIa antagonism as effective in women as in men following percutaneous coronary intervention? Lessons from ESPRIT J Am Coll Cardiol 40 2002 1085 1091
28. Freeman R.V., Mehta R.H., and Al Badr W. Influence of concurrent renal dysfunction on outcomes of patients with acute coronary syndromes and implications of the use of glycoprotein IIb/IIIa inhibitors J Am Coll Cardiol 41 2003 718 724
29. Lopes R.D., Alexander K.P., and Manoukian S.V. Advanced age, antithrombotic strategy, and bleeding in non-ST-segment elevation acute coronary syndromes: results from ACUITY J Am Coll Cardiol 53 2009 1021 1030
30. Mehta R.H., Roe M.T., and Chen A.Y. Recent trends in the care of patients with non-ST-segment elevation acute coronary syndromes: insights from CRUSADE Arch Intern Med 166 2006 2027 2034
31. Michaels A.D., Spinler S.A., and Leeper B. Medication errors in acute cardiovascular and stroke patients: a scientific statement from the American Heart Association Circulation 121 2010 1664 1682