Focal neuronal damage in patients with neuropsychological impairment after diffuse traumatic brain injury: Evaluation using 11C-flumazenil positron emission tomography with statistical image analysis

Journal of Neurotrauma

Volumn 27, Issue 12, 2010, Pages 2131-2138

  Kawai, Nobuyuki ^a   Maeda, Yukito ^b   Kudomi, Nobuyuki ^a   Yamamoto, Yuka ^b   Nishiyama, Yoshihiro ^b   Tamiya, Takashi ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

cognitive function; flumazenil; neuronal loss; positron emission tomography; traumatic brain injury

Indexed keywords

FLUMAZENIL C 11;

ADULT; ARTICLE; CINGULATE GYRUS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIFFUSE AXONAL INJURY; FEMALE; FRONTAL CORTEX; HUMAN; IMAGE ANALYSIS; INTELLIGENCE QUOTIENT; MALE; NERVE CELL LESION; POSITRON EMISSION TOMOGRAPHY; STATISTICAL ANALYSIS; THALAMUS; TRAUMATIC BRAIN INJURY; WECHSLER INTELLIGENCE SCALE;

ADULT; BRAIN; BRAIN INJURIES; BRAIN MAPPING; CARBON ISOTOPES; COGNITION; COGNITION DISORDERS; FEMALE; FLUMAZENIL; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; NEURONS; NEUROPSYCHOLOGICAL TESTS;

EID: 78650116908     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2010.1464     Document Type: Article

References (37)

1. Anderson, C.V., and Bigler, E.D. (1995). Ventricular dilatation, cortical atrophy, and neuropsychological outcome following traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 7, 42-48.
2. Anderson, C.V., Wood, D.M.G., Bigler, E.D., and Blatter, D.D. (1996). Lesion volume, injury severity, and thalamic integrity following head injury. J. Neurotrauma 16, 35-41.
3. Bigler, E.D. (2001). Quantitative magnetic resonance imaging in traumatic brain injury. J. Head Trauma Rehabil. 16, 117-134.
4. Bü ki, A., and Povlishock, J.T. (2006). All roads lead to discon-nection?\Traumatic axonal injury revisited. Acta Neurochir. (Wien.) 148, 181-194.
5. Devinski, O., Morrell, M.J., and Vogt, B.A. (1995). Contribution of anterior cingulated cortex to behaviour. Brain 118, 279-306.
6. Friston, K.J., Frith, C.D., Liddle, P.F., Dolan, R.J., Lammertsma, A.A., and Frackowiak, R.S. (1990). The relationship between global and local changes in PET scans. J. Cereb. Blood Flow Metab. 10, 458-466.
7. Fontaine, A., Azouvi, P., Remy, P., Bussel, B., and Samson, Y. (1999). Functional anatomy of neuropsychological deficits after severe traumatic brain injury. Neurology 10, 1963-1968.
8. Friston, K.J., Frith, C.D., Liddle, P.F., and Frackowiak, R.S. (1991). Comparing functional (PET) images: the assessment of significant change. J. Cereb. Blood Flow Metab. 11, 690-699.
9. Gale, S.D., Baxter, L., Roundy, N., and Johnson, S.C. (2005). Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study. J. Neurol. Neuro-surg. Psychiatry 76, 984-988.
10. Gale, S.D., Johnson, S.C., Bigler, E.D., and Blatter, D.D. (1995). Nonspecific white matter degeneration following traumatic brain injury. J. Int. Neuropsychol. Soc. 1, 17-28.
11. Gross, H., Kling, A., Henry, G., Herndon, C., and Lavretsky, H. (1996). Local cerebral glucose metabolism in patients with long-term behavioral and cognitive deficits following mild traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 8, 324-334.
12. Haier, R.J., Jung, R.E., Yeo, R.A., Head, K., and Alkire, M.T. (2004). Structural brain variation and general intelligence. Neuroimage 23, 425-433.
13. 2O positron emission tomography predicts irreversible ischemic cortical damage in stroke patients receiving acute thrombolytic therapy. Stroke 31, 366-369.
14. Hofman, P.A.M., Stapert, S.Z., van Kroonenburgh, M.J.P.G., Jolles, J., de Kruijk, J., and Wilmink, J.T. (2001). MR imaging, single-photon emission CT, and neurocognitive performance after mild traumatic brain injury. AJNR Am. J. Neuroradiol. 22, 441-449.
15. Ichise, M., Chung, D.G., Wang, P., Wortzman, G., Gray, B.G., and Franks, W. (1994). Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance. J. Nucl. Med. 35, 217-226.
16. Kato, T., Nakayama, N., Yasokawa, Y., Okumura, A., Shinoda, J., and Iwama, T. (2007). Statistical image analysis of cerebral glucose metabolism in patients with cognitive impairment following diffuse traumatic brain injury. J. Neurotrauma 24, 919-926.
17. 11C] flumazenil studies. J. Cereb. Blood Flow Metab. 28, 579-587.
18. Kuroda, S., Shiga, T., Ishikawa, T., et al. (2004). Reduced blood flow and preserved vasoreactivity characterize oxygen hypo-metabolism due to incomplete infarction in occlusive carotid artery disease. J. Nucl. Med. 45, 943-949.
19. Lifshitz, J., Kelley, B.J., and Povlishock, J.T. (2007). Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death. J. Neuropathol. Exp. Neurol. 66, 218-229.
20. Little, D.M., Kraus, M.F., Joseph, J., et al. (2010). Thalamic integrity underlies executive dysfunction in traumatic brain injury. Neurology 74, 558-564.
21. Marshall, L.F., Marshall, S.B., Klauber, M.R., et al. (1991). A new classification of head injury based on computerized tomography. J. Neurosurg. 75, S14-S20.
22. Maxwell, W.L., Pennington, K., Mackinnon, M.A., et al. (2004). Differential response in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury. Brain 127, 2470-2478.
23. Merkley, T.L., Bigler, E.D., Wilde, E.A., McCauley, S.R., Hunter, J.V., and Levin, H.S. (2008). Diffuse changes in cortical thickness in pediatric moderate-to-severe traumatic brain injury. J. Neurotrauma 25, 1343-1345.
24. Minoshima, S., Frey, K.A., Koeppe, R.A., Foster, N.L., and Kuhl, D.E. (1995). A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J. Nucl. Med. 36, 1238-1248.
25. Minoshima, S., Koeppe, R.A., Frey, K.A., Ishihara, M., and Kuhl, D.E. (1994). Stereotactic PET atlas of the human brain: aid for visual interpretation of functional brain images. J. Nucl. Med. 35, 949-954.
26. Mizumura, S., Kumita, S., Cho, K., et al. (2003). Development of quantitative analysis method for stereotactic brain image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann. Nucl. Med. 17, 289-295.
27. Nakashima, T., Nakayama, N., Miwa, K., Okumura, A., Soeda, A., and Iwama, T. (2007). Focal brain glucose hypometabolism in patients with neuropsychologic deficits after diffuse axonal injury. AJNR Am. J. Neuroradiol. 28, 236-242.
28. Nakayama, N., Okumura, A., Shinoda, J., Nakashima, T., and Iwama, T. (2006). Relationship between regional metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis. J. Neurol. Neurosurg. Psychiatry 77, 856-862.
29. Rudolf, J., Sobesky, J., Ghaemi, M., and Heiss, W.D. (2002). The correlation between cerebral glucose metabolism and benzo-diazepine receptor density in the acute vegetative state. Eur. J. Neurol. 9, 671-677.
30. Rudolf, J., Sobesky, J., Grond, M., and Heiss, W.D. (2000). Identification by positron emission tomography of neuronal loss in acute vegetative state. Lancet 355, 115-116.
31. 11C]Ro 15-1788, a benzodiazepine antagonist, studied in human brain in vivo by positron tomography. Eur. J. Pharmacol. 110, 247-251.
32. Sidaros, A., Skimminge, A., Liptrot, M.G., Sidaros, K., Engberg, A.W., Herning, M., Paulson, O.B., Jernigan, T.L., and Rostrup, E. (2009). Long-term global and regional brain volume changes following severe traumatic brain injury: a longitudinal study with clinical correlates. Neuroimage 44, 1-8.
33. Stamatakis, E.A., Wilson, J.T., Hadley, D.M., and Wyper, D.J. (2002). SPECT imaging in head injury interpreted with statistical parametric mapping. J. Nucl. Med. 43, 476-483.
34. Uzan, M., Albayram, S., Dashti, S.G.R., Aydin, S., Hanci, M., and Kuday, C. (2003). Thalamic proton magnetic resonance spec-troscopy in vegetative state induced by traumatic brain injury. J. Neurol. Neurosurg. Psychiatry 74, 33-38.
35. Yamauchi, H., Kudoh, T., Kishibe, Y., Iwasaki, J., and Kagawa, S. (2007). Selective neuronal damage and chronic hemodynamic cerebral ischemia. Ann. Neurol. 61, 454-465.
36. Yamauchi, H., Nishii, R., Higashi, T., Kagawa, S., and Fukuyama, H. (2009). Hemodynamic compromise as a cause of internal border-zone infarction and cortical neuronal damage in atherosclerotic middle cerebral artery disease. Stroke 40, 3730-3735.
37. 18F] FDG-PET imaging in traumatic brain injury. J. Neurotrauma 27, 35-49.