Immunohistochemical evidences showing the presence of thymulin containing cells located in involuted thymus and in peripheral lymphoid organs

Biological Research

Volumn 43, Issue 3, 2010, Pages 291-298

  Folch, Hugo ^a   Villegas, Juana V ^b   Leyan, Víctor ^a   Barría, Miguel ^a   Eller, Gisela ^c   Esquivel, Patricio ^a  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^b UNIVERSIDAD DE LA FRONTERA   (Chile)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Facteur thymique serique; Thymic hormones; Thymulin

Indexed keywords

MUS;

EID: 78650061270     PISSN: 07169760     EISSN: 07176287     Source Type: Journal    
DOI: 10.4067/S0716-97602010000300005     Document Type: Article

References (29)

1. BACH JF, DARDENNE M (1972) Thymus dependency of rosette forming cells. Evidence for a circulating thymic hormone. Transplant Proc 4: 345-349.
2. BACH JF, DARDENNE M (1973) Studies on thymus products. II. Demonstration and characterization of a circulating thymic hormone. Inmunology 25: 353-366.
3. BACH J, DARDENNE M, GOLDSTEIN AL (1984) Thymic hormones and lymphokines. In: GOLDSTEIN AL (ed) Clinical Aspects of thymulin (FTS). New York: Plenum Press. pp 593-600.
4. BERRIH S, SAVINO W, AZOULAY M, DARDENNE M, BACH JF (1984) Production of anti-thymulin (FTS) monoclonal antibodies by immunization against human thymic epithelial cells. J Histochem Cytochem 32: 432-438.
5. BLAIS ME, BROCHU S, GIROUX M, BELANGER MP, DULUDE G, SEKALY RP, PERREAULT C (2008) Why T cells of thymic versus extrathymic origin are functionally different. J Immunol 180: 2299-2312.
6. CONSOLINI R, LEGITIMO A, CALLERI A, MILANI M (2000) Distribution of age-related thymulin titres in normal subjects through the course of life. Clin Exp Immunol 121:444-447.
7. CUNG MT, MARRAUD M, LEFRANCIER P, DARDENNE M, BACH JF, LAUSSAC JP (1988) NMR study of a lymphocyte differentiating thymic factor. J Biol Chem 263: 5574-5580.
8. DARDENNE M, CHARREIRE J, BACH JF (1978) Alterations in thymocyte surface markers after in vivo treatment by serum thymic factor. Cell Immunol 39:47-54.
9. DARDENNE M, NABARRA B, LEFRANCIER P (1982) Contribution of zinc and other metals to the biological activity of serum thymic factor (FTS). Proc Natl Acad Sci USA 79: 5370-5373.
10. DARDENNE, M, PAPIERNIK M, BACH JF, STUTMAN O (1974) Studies on thymus products. III. Epithelial origin of the serum thymic factor. Immunology 27: 299-304.
11. DARDENNE M, SAADE N, SAFIEH-GARABEDIAN B (2006). Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci 1088: 153-63.
12. DARDENNE M, SAVINO W, GAGNERAULT MC, ITOH T, BACH JF (1989) Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. Endocrinology 125:3-12.
13. FABRIS N, MOCCHEGIANI E (1985) Endocrine control of thymic serum factor production in young adult and old mice. Cell Immunol 91:325-335.
14. GASTINEL LN, DARDENNE M, PLEAU JM, BACH JF (1984) Studies on the zinc-binding site to the serum thymic factor. Biochim Biophys Acta 797: 147-155.
15. GOYA RG, REGGIANI PC, VESENBECKH SM, PLÉAU JM, SOSA YE, CÓNSOLE GM, SCHADE R, HENKLEIN P, DARDENNE M (2007) Thymulin gene therapy prevents the reduction in circulating gonadotropins induced by thymulin deficiency in mice. Am J Physiol Endocrinol Metab 293: E182-187.
16. HAWKES R, NIDAY E, GORDON J (1982) A dot-inmunobinding assay for monoclonal and other antibodies. Anal Biochem 119: 142-147.
17. INCEFY GS, MERTELSMANN R, YATA K, DARDENNE M, BACH JF, GOOD RA (1980) Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS. Clin Exp Immunol 40: 396-406.
18. JAMBON B, MONTAGNE P, BENE MC, BRAYER MP, FAURE G, DUHEILLE J (1981) Immunohistologic localization of "facteur thymique sérique"(FTS) in human thymic epithelium. J Inmunol 127: 2055-2059.
19. KATO K, IDEYAMA S, TAKAOKI M, SHINO A, YAKAUCHI M, KAKINUMA A (1981) Epithelial cell components immunoreact with antiserum thymic factor antibodies: possible association with intermediate-sized filaments. Cell 24: 885-895.
20. LAKE J P, PIERCE CW, KENNEDY JD (1991). T cell receptor expression by T cells that mature extrathymicaliy in numde mice. Cell Immunol 135: 259-265.
21. LAWETZKY A, HUNIG T (1988) Analysis of CD3 and antigen receptor expression on T cell subpopulations of aged athymic mice. Eur J Immunol 18:409-416.
22. MACDONALD HR, LEES RK, SORDAT B, ZAECH P, MARYANSKI JL, BRON C (1981) Age-associated increase in expression of the T cell surface markers Thy-1, Lyt-1, and Lyt-2 in congenitally athymic (nu/ nu) mice: analysis by flow microfluorometry. J Immunol 126: 865-870.
23. MASON DY, CORDELL JL, ABDULAZIZ Z, NAIEM M, BORDENAVE G (1982) Preparation of peroxidase: antiperoxidase (PAP) complexes for immunohistological labeling of monoclonal antibodies. J Histochem Cytochem 30:1114-1122.
24. REGGIANI PC, MOREL GR, CÓNSOLE GM, BARBEITO CG, RODRIGUEZ SA, BROWN OA, BELLINI MJ, PLÉAU JM, DARDENNE M, GOYA RG (2009) The thymus-neuroendocrine axis. Physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin. Ann NY Acad Sci 1153: 98-106.
25. SAFIEH-GARABEDIAN B, DARDENNE M, PLEAU J-M, SAADE NE (2002) Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. Br J Pharmacol 136: 947-955.
26. SAFIEH-GARABEDIAN B, OCHOA-CHAAR CI, POOLE S, MASSAAD CA, ATWEH SF, JABBUR SJ, SAADE NE (2003) Thymulin reverses inflammatory hyperalgesia and modulates the increased concentration of proinflammatory cytokines induced by i.c.v. endotoxin injection. Neuroscience 121: 865-873.
27. STERNBERGER LA, HARDY PH JR, CUCULIS JJ, MEYER HG (1970) The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18:315-333.
28. STUTMAN O (1983) Role of thymic hormones in T cell differentiation in J F BACH (ed) Clinics in Immunology and Allergy, London: W B Sounders. pp: 6-67.
29. VILLEGAS J, ELLER G, LEYÁN V, ESQUIVEL P, FOLCH H (1991) Preparación y caracterización de complejo peroxidasa-antiperoxidasa monoclonal. Arch Biol Med Exp 24: 61-66.