-
1
-
-
17644389199
-
TNF/TNFR family members in costimulation of T cell responses
-
Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-68
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 23-68
-
-
Watts, T.H.1
-
2
-
-
38549176118
-
Tumour necrosis factor antagonist mechanism of action: A comprehensive review
-
This article gives a detailed overview of anti-TNF-a
-
Tracey D, Klareskog L, Sasso EH, et al. Tumour necrosis factor antagonist mechanism of action: A comprehensive review. Pharmacol Ther 2008;117:244-79 This article gives a detailed overview of anti-TNF-a.
-
(2008)
Pharmacol Ther
, vol.117
, pp. 244-79
-
-
Tracey, D.1
Klareskog, L.2
Sasso, E.H.3
-
3
-
-
33748293143
-
Etiopathogenesis of inflammatory bowel diseases
-
This paper focuses on the recent advances in the knowledge of aetiology and pathogenesis of IBD
-
Danese S, Fiocchi C. Etiopathogenesis of inflammatory bowel diseases. World J Gastroenterol 2006;12:4807-12 This paper focuses on the recent advances in the knowledge of aetiology and pathogenesis of IBD.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 4807-12
-
-
Danese, S.1
Fiocchi, C.2
-
4
-
-
0025912981
-
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease
-
Murch SH, Lamkin VA, Savage MO, et al. Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease. Gut 1991;32:913-17
-
(1991)
Gut
, vol.32
, pp. 913-17
-
-
Murch, S.H.1
Lamkin, V.A.2
Savage, M.O.3
-
5
-
-
0027486125
-
MacDonald Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease
-
Murch SH, Braegger CP, Walker-Smith JA, MacDonald. Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993;34;1705-9
-
(1993)
Gut
, vol.34
, pp. 1705-9
-
-
Murch, S.H.1
Braegger, C.P.2
Walker-Smith, J.A.3
-
6
-
-
45849083467
-
Mechanisms of action of infliximab in inflammatory bowel disease: An anti-inflammatory multitasker
-
Danese S. Mechanisms of action of infliximab in inflammatory bowel disease: An anti-inflammatory multitasker. Dig Liver Dis 2008;40(Suppl 2):S225-8
-
(2008)
Dig Liver Dis
, vol.40
, Issue.SUPPL. 2
-
-
Danese, S.1
-
7
-
-
44649187924
-
Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Meta-analysis of placebo-controlled trials
-
A key paper that analyses efficacy and safety of anti-TNF-a in Crohn's disease
-
Peyrin-Biroulet L, Deltenre P, de Suray N, et al. Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: Meta-analysis of placebo-controlled trials. Clin Gastroenterol Hepatol 2008;6:644-53 A key paper that analyses efficacy and safety of anti-TNF-a in Crohn's disease.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 644-53
-
-
Peyrin-Biroulet, L.1
Deltenre, P.2
De Suray, N.3
-
8
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
This is the first, to our knowledge, large randomized trial on infliximab in ulcerative colitis
-
Rutgeerts P, Sandborn WJ, Feagan B, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005;233:2462-73 This is the first, to our knowledge, large randomized trial on infliximab in ulcerative colitis.
-
(2005)
N Engl J Med
, vol.233
, pp. 2462-73
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.3
-
9
-
-
62049083383
-
Loss of response and requirement of infliximab dose intensification in Crohn's disease: A review
-
Gisbert JP, Panes J. Loss of response and requirement of infliximab dose intensification in Crohn's disease: A review. Am J Gastroenterol 2009;104:760-7
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 760-7
-
-
Gisbert, J.P.1
Panes, J.2
-
10
-
-
0037434552
-
Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
-
This article investigates the role of immunogenicity in loss of response to anti-TNF-a
-
Baert F, Noman M, Vermeire S, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 2003;341:601-8 This article investigates the role of immunogenicity in loss of response to anti-TNF-a.
-
(2003)
N Engl J Med
, vol.341
, pp. 601-8
-
-
Baert, F.1
Noman, M.2
Vermeire, S.3
-
11
-
-
0034716486
-
Therapeutic monoclonal antibodies
-
Breedveld FC. Therapeutic monoclonal antibodies. Lancet 2000;355(9205):735-40
-
(2000)
Lancet
, vol.355
, Issue.9205
, pp. 735-40
-
-
Breedveld, F.C.1
-
12
-
-
32044451548
-
Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
-
This is the largest RCT on efficacy of adalimumab for the induction of remission in naïve patients with active CD
-
Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial. Gastroenterology 2006;130:323-33 This is the largest RCT on efficacy of adalimumab for the induction of remission in naïve patients with active CD.
-
(2006)
Gastroenterology
, vol.130
, pp. 323-33
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
-
13
-
-
34249281002
-
Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
-
This is the largest RCT on efficacy of adalimumab for the maintenance of remission in naïve patients with CD
-
Sandborn WJ, Hanauer SB, Rutgeerts P. Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial. Gut 2007;56:1232-9 This is the largest RCT on efficacy of adalimumab for the maintenance of remission in naïve patients with CD.
-
(2007)
Gut
, vol.56
, pp. 1232-9
-
-
Sandborn, W.J.1
Hanauer, S.B.2
Rutgeerts, P.3
-
14
-
-
34347402306
-
Adalimumab induction therapy for Crohn disease previously treated with infliximab: A randomized trial
-
This is the most important RCT on the efficacy of adalimumab in gaining response for patients that failed infliximab
-
Sandborn WJ, Rutgeerts P, Enns R, et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab: A randomized trial. Ann Intern Med 2007;146:829-38 This is the most important RCT on the efficacy of adalimumab in gaining response for patients that failed infliximab.
-
(2007)
Ann Intern Med
, vol.146
, pp. 829-38
-
-
Sandborn, W.J.1
Rutgeerts, P.2
Enns, R.3
-
15
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
-
This large trial investigated the maintenance dose of adalimumab in patients with CD
-
Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial. Gastroenterology 2007;132:52-65 This large trial investigated the maintenance dose of adalimumab in patients with CD.
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
-
16
-
-
70350130547
-
Influence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease
-
This study showed that immunogenicity can result in loss of response to adalimumab
-
Karmiris K, Paintaud G, Noman M, et al. Influence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease. Gastroenterology 2009;137:1628-40 This study showed that immunogenicity can result in loss of response to adalimumab.
-
(2009)
Gastroenterology
, vol.137
, pp. 1628-40
-
-
Karmiris, K.1
Paintaud, G.2
Noman, M.3
-
17
-
-
77954725434
-
Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis
-
This is the first RCT, to our knowledge, intended to investigate efficacy and safety of adalimumab in UC
-
Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis. J Crohn's Colitis 2010;4(1):S5 This is the first RCT, to our knowledge, intended to investigate efficacy and safety of adalimumab in UC.
-
(2010)
J Crohn's Colitis
, vol.4
, Issue.1
-
-
Reinisch, W.1
Sandborn, W.J.2
Hommes, D.W.3
-
18
-
-
34249857135
-
Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study
-
This is the first study, to our knowledge, on adalimumab as induction therapy in active UC
-
Peyrin-Biroulet L, Laclotte C, Roblin X, Bigard MA. Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study. World J Gastroenterol 2007;13:2328-32 This is the first study, to our knowledge, on adalimumab as induction therapy in active UC.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 2328-32
-
-
Peyrin-Biroulet, L.1
Laclotte, C.2
Roblin, X.3
Bigard, M.A.4
-
19
-
-
52149104260
-
Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: A single-centre experience
-
This is the first study, to our knowledge, on adalimumab as maintenance therapy in UC
-
Oussalah A, Laclotte C, Chevaux JB, et al. Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: A single-centre experience. Aliment Pharmacol Ther 2008;28:966-72 This is the first study, to our knowledge, on adalimumab as maintenance therapy in UC.
-
(2008)
Aliment Pharmacol Ther
, vol.28
, pp. 966-72
-
-
Oussalah, A.1
Laclotte, C.2
Chevaux, J.B.3
-
20
-
-
70449727863
-
Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab
-
Afif W, Leighton JA, Hanauer SB, et al. Open-label study of adalimumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab. Inflamm Bowel Dis 2009;15:1302-7
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 1302-7
-
-
Afif, W.1
Leighton, J.A.2
Hanauer, S.B.3
-
21
-
-
77954752112
-
Treatment of ulcerative colitis with adalimumab or infliximab: Long-term follow-up of a single-centre cohort
-
Gies N, Kroeker KI, Wong K, Fedorak RN. Treatment of ulcerative colitis with adalimumab or infliximab: Long-term follow-up of a single-centre cohort. Aliment Pharmacol Ther 2010;32:522-8
-
Aliment Pharmacol Ther
, vol.2010
, Issue.32
, pp. 522-8
-
-
Gies, N.1
Kroeker, K.I.2
Wong, K.3
Fedorak, R.N.4
-
22
-
-
78650072184
-
Adalimumab for ulcerative colitis patients previously treated with infliximab: Outcomes at short and long term and predictors of response
-
Taxonera C, Estelles J, Blanco I, et al. Adalimumab for ulcerative colitis patients previously treated with infliximab: Outcomes at short and long term and predictors of response. Gastroenterology 2010;138(5):S61
-
(2010)
Gastroenterology
, vol.138
, Issue.5
-
-
Taxonera, C.1
Estelles, J.2
Blanco, I.3
-
23
-
-
78650063811
-
The outcome of active ulcerative colitis treated with adalimumab
-
Hudis N, Rajca B, Polyak S, et al. The outcome of active ulcerative colitis treated with adalimumab. Gastroenterology 2009;136(5):A661
-
(2009)
Gastroenterology
, vol.136
, Issue.5
-
-
Hudis, N.1
Rajca, B.2
Polyak, S.3
-
24
-
-
78650068536
-
Efficacy of adalimumab in the treatment of ulcerative colitis
-
Garcia-Bosch O, Aceituno M, Perez J, et al. Efficacy of adalimumab in the treatment of ulcerative colitis. J Crohn's Colitis 2010;4(1):S55
-
(2010)
J Crohn's Colitis
, vol.4
, Issue.1
-
-
Garcia-Bosch, O.1
Aceituno, M.2
Perez, J.3
-
25
-
-
70350446513
-
Adalimumab in ulcerative colitis: Two cases of mucosal healing and clinical response at two years
-
Barreiro-de Acosta M, Lorenzo A, Dominguez-Munoz JE. Adalimumab in ulcerative colitis: Two cases of mucosal healing and clinical response at two years. World J Gastroenterol 2009;15:3814-16
-
(2009)
World J Gastroenterol
, vol.15
, pp. 3814-16
-
-
Barreiro-de Acosta, M.1
Lorenzo, A.2
Dominguez-Munoz, J.E.3
-
26
-
-
70349418632
-
Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
-
This study shows that infliximab affects the reduction of colectomy rate in patients with active severe UC.
-
Sandborn WJ, Rutgeerts P, Feagan BG, et al. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 2009;137:1250-60 This study shows that infliximab affects the reduction of colectomy rate in patients with active severe UC.
-
(2009)
Gastroenterology
, vol.137
, pp. 1250-60
-
-
Sandborn, W.J.1
Rutgeerts, P.2
Feagan, B.G.3
-
27
-
-
20444479336
-
Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study
-
Jarnerot G, Hertervig E, Friis-Liby I, et al. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: A randomized, placebo-controlled study. Gastroenterology 2005;128:1805-11
-
(2005)
Gastroenterology
, vol.128
, pp. 1805-11
-
-
Jarnerot, G.1
Hertervig, E.2
Friis-Liby, I.3
-
28
-
-
0028338424
-
Course of ulcerative colitis: Analysis of changes in disease activity over years
-
This is a milestone among epidemiological studies of IBD
-
Langholz E, Munkholm P, Davidsen M, Binder V. Course of ulcerative colitis: Analysis of changes in disease activity over years. Gastroenterology 1994;107:3-11 This is a milestone among epidemiological studies of IBD.
-
(1994)
Gastroenterology
, vol.107
, pp. 3-11
-
-
Langholz, E.1
Munkholm, P.2
Davidsen, M.3
Binder, V.4
-
29
-
-
39449085441
-
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
-
This is the first study, to our knowledge, comparing 'top down' and 'step up' approaches in IBD
-
D'Haens G, Baert F, van Assche G, et al. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial. Lancet 2008;371(9613):660-7 This is the first study, to our knowledge, comparing 'top down' and 'step up' approaches in IBD.
-
(2008)
Lancet
, vol.371
, Issue.9613
, pp. 660-7
-
-
D'Haens, G.1
Baert, F.2
Van Assche, G.3
-
30
-
-
77950988234
-
Infliximab azathioprine or combination therapy for Crohn's disease
-
This is a large study evaluating the efficacy of combined immunosuppression versus monotherapy in CD
-
Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010;362:1383-95 This is a large study evaluating the efficacy of combined immunosuppression versus monotherapy in CD.
-
N Engl J Med
, vol.2010
, Issue.362
, pp. 1383-95
-
-
Colombel, J.F.1
Sandborn, W.J.2
Reinisch, W.3
-
31
-
-
78650057460
-
-
Efficacy & Safety of Infliximab Monotherapy Vs Combination Therapy Vs AZA Monotherapy in Ulcerative Colitis (Part 1) Maintenance Vs Intermittent Therapy for Maintaining Remission (Part 2)(Study P04807AM3). Bethesda, MD: Clinicaltrials.gov, Available from: Last accessed 20 November 2010
-
Efficacy & Safety of Infliximab Monotherapy Vs Combination Therapy Vs AZA Monotherapy in Ulcerative Colitis (Part 1) Maintenance Vs Intermittent Therapy for Maintaining Remission (Part 2)(Study P04807AM3). Bethesda, MD: Clinicaltrials.gov, 2007. Available from: Http://clinicaltrials. gov/ct2/show/NCT00537316? term=NCT00537316.&rank=1 [Last accessed 20 November 2010]
-
(2007)
-
-
|