Drug delivery trends in clinical trials and translational medicine: Evaluation of pharmacokinetic properties in special populations

Journal of Pharmaceutical Sciences

Volumn 100, Issue 1, 2011, Pages 53-58

  Chien, Jenny Y ^a   Ho, Rodney J Y ^b  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

ADME; Clinical pharmacokinetics; Elderly; Inclusions; Pediatric; Pharmacokinetics; Pharmacokinetics pharmacodynamics; Physiological model; Population pharmacokinetics pharmacodynamics

Indexed keywords

AGED; ARTICLE; CHILD; CHILD CARE; CLINICAL RESEARCH; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; ELDERLY CARE; HUMAN; RESEARCH SUBJECT;

EID: 78650046009     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22253     Document Type: Article

References (9)

1. Chien JY, Ho RJ. 2008. Drug delivery trends in clinical trials and translational medicine. J Pharm Sci 97: 2543-2547.
2. Ho RJ, Chien JY. 2009. Drug delivery trends in clinical trials and translational medicine: Updated analysis of ClinicalTrials.gov. database. J Pharm Sci 98: 1928-1934.
3. Center for Disease Control Factsheets. and .
4. McLean AJ, Le Couteur DG. 2004. Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56: 163-184.
5. Rodriguez W, Selen A, Avant D, Chaurasia C, Crescenzi T, Gieser G, Di Giacinto J, Huang SM, Lee P, Mathis L, Murphy D, Murphy S, Roberts R, Sachs HC, Suarez S, Tandon V, Uppoor RS. 2008. Improving pediatric dosing through pediatric initiatives: What we have learned. Pediatrics 121: 530-539.
6. FDA Guideline for Industry: Studies in Support of Special Populations: Geriatrics. ICH E7 1994. .
7. Best Pharmaceutical for Children Act, 2002. .
8. Jamei M, Marciniak S, Feng K, Barnett A, Tucker G, Rostami-Hodjegan A. 2009. The Simcyp® Population-based ADME Simulator Expert Opin Drug Metab Toxicol. 5: 211-223.
9. Skirboll L. Federal Register. May 21, 2008, Vol. 73, No. 99. Notice.