Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of petasites hybridus rhizomes in rat hepatocytes

Planta Medica

Volumn 77, Issue 1, 2011, Pages 32-39

  Bodensieck, Antje ^a   Gaunitz, Frank ^b   Gebhardt, Rolf ^b   Danesch, Ulrich ^c   Bauer, Rudolf ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Research and Development   (Germany)

Author keywords

Asteraceae; cytotoxicity; eremophilane sesquiterpenes; hepatocytes; Petasites hybridus; stereoisomerism

Indexed keywords

2 [(ANGELOYL)OXY] 9 HYDROXYEREMOPHIL 7(11) EN 12,8 OLIDE; 2 [(ANGELOYL)OXY]EREMOPHIL 7(11) EN 12,8 OLIDE; 2 [(METHACROYL)OXY]EREMOPHIL 7(11) EN 12,8 OLIDE; 2 [[3 (METHYLSULFANYL)PROP 2 ENOYL]OXY)EREMOPHIL 7(11) EN 12,8 OLIDE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 8 HYDROXYEREMOPHIL 7(11) EN 12,8 OLIDE; 8 OXOEREMOPHIL 7(11),9 DIEN 3 YL 3 (METHYLSULFANYL)PROP 2 ENOATE; EREMOPHIL 7(11) EN 12,8 OLIDE; EREMOPHILANE DERIVATIVE; LACTATE DEHYDROGENASE; SESQUITERPENE; SESQUITERPENE LACTONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DENSITY; CELL RESPIRATION; CELL VIABILITY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENERGY METABOLISM; ENZYME RELEASE; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; NONHUMAN; PETASITES; RAT; RHIZOME; STEREOCHEMISTRY; STEREOISOMERISM;

ANIMALS; CELL MEMBRANE; CELL RESPIRATION; CYTOTOXINS; ENERGY METABOLISM; HEPATOCYTES; NAPHTHALENES; PETASITES; RATS; RHIZOME; SESQUITERPENES; TETRAZOLIUM SALTS; THIAZOLES;

ASTERACEAE; PETASITES HYBRIDUS; RATTUS;

EID: 78650042248     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250112     Document Type: Article

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