Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Liu, Xijun ^a,c   Yang, Jin Ming ^a   Zhang, Samuel S ^a,b   Liu, Xin Yuan ^c,d   Liu, David X ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c ZHEJIANG SCI TECH UNIVERSITY   (China)

^d INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIN D1; CYCLIN E; CYCLOHEXIMIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; CELL CYCLE PROTEIN; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLIOMA CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BRAIN TUMOR; CELL PROLIFERATION; CELL SHAPE; DOSE RESPONSE; DRUG EFFECT; GLIOMA; METABOLISM; PATHOLOGY; TIME; TUMOR CELL LINE; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CYCLIC AMP; CYCLOHEXIMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; PROTEIN SYNTHESIS INHIBITORS; RATS; S PHASE; TIME FACTORS; UP-REGULATION;

EID: 78650039418     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-684     Document Type: Article

References (29)

1. McLendon R, Enterline D, Tien R, Thorstad W, Bruner J. Russell and Rubinstein's Pathology of Tumors of the Nervous System. 1998, Chapter 9:307-571. Oxford University Press: New York, Bigner D, McLendon R, Bruner J.
2. Leszczyniecka M, Roberts T, Dent P, Grant S, Fisher PB. Differentiation therapy of human cancer: basic science and clinical applications. Pharmacology & Therapeutics 2001, 90:105-56.
3. Prasad KN, Kentroti S, Edwards-Prasad J, Vernadakis A, Imam M, Carvalho E, Kumar S. Modification of the expression of cAMP-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate. Journal of the American College of Nutrition 1994, 13:298-303.
4. Rudie Hovland A, Nahreini P, Andreatta CP, Edwards-Prasad J, Prasad KN. Identifying genes involved in regulating differentiation of neuroblastoma cells. Journal of Neuroscience Research 2001, 64:302-10. 10.1002/jnr.1079, 11319775.
5. Nahreini P, Andreatta CP, Prasad KN, Toribara NW. VP16CREB-induced differentiation of neuroblastoma. Indian Journal of Pediatrics 2008, 75:1009-13. 10.1007/s12098-008-0176-5, 18810352.
6. Prasad KN, Cole WC, Yan XD, Nahreini P, Kumar B, Hanson A, Prasad JE. Defects in cAMP-pathway may initiate carcinogenesis in dividing nerve cells: a review. Apoptosis 2003, 8:579-86. 10.1023/A:1026179324295, 14574064.
7. Yan XD, Hanson AJ, Nahreini P, Koustas WT, Andreatta C, Prasad KN. Altered expression of genes regulating cell growth, proliferation, and apoptosis during cAMP- induced differentiation of neuroblastoma cells in culture. In Vitro Cellular & Developmental Biology Animal 2002, 38:529-37.
8. Li Y, Yin W, Wang X, Zhu W, Huang Y, Yan G. Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:13438-43. 10.1073/pnas.0701990104, 1940034, 17679696.
9. Sasaki T, Yamazaki K, Yamori T, Endo T. Inhibition of proliferation and induction of differentiation of glioma cells with Datura stramonium agglutinin. British Journal of Cancer 2002, 87:918-23. 10.1038/sj.bjc.6600550, 2376164, 12373609.
10. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, Wang ZY. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988, 72:567-72.
11. Wang ZY, Chen Z. Differentiation and apoptosis induction therapy in acute promyelocytic leukaemia. Lancet Oncology 2000, 1:101-6. 10.1016/S1470-2045(00)00017-6, 11905660.
12. Obrig TG, Culp WJ, McKeehan WL, Hardesty B. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. Journal of Biological Chemistry 1971, 246:174-81.
13. Zhang L, Wali A, Ramana CV, Rishi AK. Cell growth inhibition by okadaic acid involves gut-enriched Kruppel-like factor mediated enhanced expression of c-Myc. Cancer Research 2007, 67:10198-206. 10.1158/0008-5472.CAN-07-2505, 17974960.
14. Moon J, Yu SJ, Kim HS, Sohn J. Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng. Biochemical Pharmacology 2000, 59:1109-16. 10.1016/S0006-2952(00)00235-5, 10704940.
15. Shih SR, Weng KF, Stollar V, Li ML. Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells. Journal of Neurovirology 2008, 14:53-61. 10.1080/13550280701798980, 18300075.
16. Eriksson D, Lofroth PO, Johansson L, Riklund K, Stigbrand T. Apoptotic signaling in HeLa Hep2 cells following 5 Gy of cobalt-60 gamma radiation. Anticancer Research 2009, 29:4361-6.
17. Liu DX, Greene LA. Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 2001, 32:425-38. 10.1016/S0896-6273(01)00495-0, 11709154.
18. Alessenko AV, Boikov P, Filippova GN, Khrenov AV, Loginov AS, Makarieva ED. Mechanisms of cycloheximide-induced apoptosis in liver cells. FEBS Letters 1997, 416:113-6. 10.1016/S0014-5793(97)01161-7, 9369245.
19. Ito K, Kiyosawa N, Kumagai K, Manabe S, Matsunuma N, Yamoto T. Molecular mechanism investigation of cycloheximide-induced hepatocyte apoptosis in rat livers by morphological and microarray analysis. Toxicology 2006, 219:175-86. 10.1016/j.tox.2005.11.017, 16368179.
20. Blom WM, de Bont HJ, Meijerman I, Mulder GJ, Nagelkerke JF. Prevention of cycloheximide-induced apoptosis in hepatocytes by adenosine and by caspase inhibitors. Biochemical Pharmacology 1999, 58:1891-8. 10.1016/S0006-2952(99)00268-3, 10591143.
21. Riccardi C, Nicoletti I. Analysis of apoptosis by propidium iodide staining and flow cytometry. Nature Protocols 2006, 1:1458-61. 10.1038/nprot.2006.238, 17406435.
22. Li G, Li W, Angelastro JM, Greene LA, Liu DX. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Molecular Cancer Research: MCR 2009, 7:933-43. 10.1158/1541-7786.MCR-08-0365, 2880174, 19531563.
23. Messens J, Slegers H. Synthesis of glial fibrillary acidic protein in rat C6 glioma in chemically defined medium: cAMP-dependent transcriptional and translational regulation. Journal of Neurochemistry 1992, 58:2071-80. 10.1111/j.1471-4159.1992.tb10948.x, 1315374.
24. Takanaga H, Yoshitake T, Hara S, Yamasaki C, Kunimoto M. cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. Journal of Biological Chemistry 2004, 279:15441-7. 10.1074/jbc.M311844200, 14754894.
25. Yanagisawa M, Nakashima K, Taga T. STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M. Neuroscience Letters 1999, 269:169-72. 10.1016/S0304-3940(99)00447-4, 10454159.
26. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T. Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Cytokine 2001, 14:264-71. 10.1006/cyto.2001.0883, 11444906.
27. Moylan RD, Brooker G. Cycloheximide potentiation of prostaglandin E1- and cholera toxin-stimulated cAMP accumulation in NG108-CC15 neuroblastoma-glioma hybrid cells. Journal of Biological Chemistry 1981, 256:6573-6.
28. Borasio PG, Pavan B, Fabbri E, Ginanni-Corradini F, Arcelli D, Poli A. Adenosine analogs inhibit acetylcholine release and cAMP synthesis in the guinea-pig superior cervical ganglion. Neuroscience Letters 1995, 184:97-100. 10.1016/0304-3940(94)11178-L, 7724055.
29. Kim YH, Choi MR, Song DK, Huh SO, Jang CG, Suh HW. Regulation of c-fos gene expression by lipopolysaccharide and cycloheximide in C6 rat glioma cells. Brain Research 2000, 872:227-30. 10.1016/S0006-8993(00)02477-X, 10924699.