Potential applications for using stem cells in spine surgery

Current Stem Cell Research and Therapy

Volumn 5, Issue 4, 2010, Pages 345-355

  Goldschlager, Tony ^a,b,c   Jenkin, Graham ^b   Ghosh, Peter ^d   Zannettino, Andrewr ^e   Rosenfeld, Jeffrey Victor ^a,c  

^a ALFRED HOSPITAL   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d ROYAL NORTH SHORE HOSPITAL   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Intervertebral disc; Mesenchymal stem cell; Spine fusion; Spine surgery; Stem cell

Indexed keywords

GROWTH FACTOR;

ADULT STEM CELL; ANTIINFLAMMATORY ACTIVITY; ARTHROPLASTY; BONE REGENERATION; CELL DIFFERENTIATION; CELL MIGRATION; CERVICAL SPINE; EMBRYONIC STEM CELL; EPITHELIUM CELL; HUMAN; IMMUNOMODULATION; INFLAMMATION; INTERVERTEBRAL DISKECTOMY; LUMBAR SPINE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROSURGERY; NONHUMAN; PAIN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; SPINE DISEASE; SPINE FUSION; SPINE SURGERY; STEM CELL TRANSPLANTATION;

ADULT STEM CELLS; ANIMALS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; IMMUNOSUPPRESSION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STEM CELLS; PLURIPOTENT STEM CELLS; SPINAL CORD INJURIES; SPINAL CORD REGENERATION; STEM CELL NICHE; STEM CELL TRANSPLANTATION;

EID: 78650009052     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488810793351686     Document Type: Review

References (168)

1. NIH. Stem Cell Information. 2008; Available from: http://stemcells.nih.gov/info/basics/basics2.asp.
2. Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282(5391): 1145-7.
3. Trounson A. Human embryonic stem cells: mother of all cell and tissue types. Reprod Biomed Online 2002; 4 (Suppl 1): 58-63.
4. Rosenfeld J, Bandopadhayay P, Goldschlager T, Brown D. The Ethics of the Treatment of Spinal Cord Injury: Stem Cell Transplants, Motor Neuroprosthetics, and Social Equity. Top Spinal Cord Inj Rehabil 2008; 14(1): 76-88.
5. Jeffrey S. First Embryonic Stem-Cell-Based Therapy Trial in Spinal-Cord Injury Gets FDA Nod New York: Web MD Professional; 2009; Available from: http://www.medscape.com/-viewarticle/587411.
6. Caplan AI. New Era of Cell-Based Orthopaedic Therapies. Tissue Eng Part B Rev 2009; 15(2): 195-200.
7. MacMillan ML, Davies SM, Nelson GO, et al. Twenty years of unrelated donor bone marrow transplantation for pediatric acute leukemia facilitated by the National Marrow Donor Program. Biol Blood Marrow Transplant 2008; 14(9 Suppl): 16-22.
8. Castro-Malaspina H, Gay RE, Resnick G, et al. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood 1980; 56(2): 289-301.
9. Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet 1970; 3(4): 393-403.
10. Dennis J, Caplan A. Bone Marrow Mesenchymal Stem Cells. Stem Cell Handbook. Albany, New York: Humana Press; 2003. p. 108.
11. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13(12): 4279-95.
12. Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005; 52(8): 2521-9.
13. Young HE, Steele TA, Bray RA, et al. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec 2001; 264(1): 51-62.
14. Brisby H, Tao H, Ma D, Diwan A. Cell therapy for disc degeneration--potentials and pitfalls. Orthop Clin North Am 2004; 35(1): 85-93.
15. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007; 25(10): 2648-59.
16. Long X, Olszewski M, Huang W, Kletzel M. Neural cell differentiation in vitro from adult human bone marrow mesenchymal stem cells. Stem Cells Dev 2005; 14(1): 65-9.
17. Dominici M, Le Blanc K, Mueller I, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8(4): 315-7.
18. De Ugarte DA, Alfonso Z, Zuk PA, et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett 2003; 89(2-3): 267-70.
19. Locke M, Windsor J, Dunbar PR. Human adipose-derived stem cells: isolation, characterization and applications in surgery. ANZ J Surg 2009; 79(4): 235-44.
20. Conget PA, Minguell JJ. Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells. J Cell Physiol 1999; 181(1):67-73.
21. Liu TM, Martina M, Hutmacher DW, et al. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007; 25(3): 750-60.
22. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 2004; 13(4): 436-48.
23. Ho AD, Wagner W, Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy 2008; 10(4): 320-30.
24. Zannettino AC, Paton S, Arthur A, et al. Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. J Cell Physiol 2008; 214(2): 413-21.
25. Caplan AI. All MSCs are pericytes? Cell Stem Cell 2008; 3(3): 229-30.
26. Goldschlager T, Jenkin G, Rosenfeld JV, Ghosh P. Chondrogenic differentiation of adipose-derived stem cells. ANZ J Surg [Letter to the Editor]. 2009; 79(11): 856-7.
27. Im GI, Shin YW, Lee KB. Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? Osteoarthritis Cartilage 2005; 13(10): 845-53.
28. Content and Review of Chemistry, Manufacturing, and Control (CMC) Information for Human Somatic Cell Therapy Investigational New Drug Applications, April 2008.
29. Doherty MJ, Ashton BA, Walsh S, et al. Vascular pericytes express osteogenic potential in vitro and in vivo. J Bone Miner Res 1998; 13(5): 828-38.
30. Risbud MV, Guttapalli A, Tsai TT, et al. Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine 2007; 32(23): 2537-44.
31. Simmons PJ, Gronthos S, Zannettino A, Ohta S, Graves S. Isolation, characterization and functional activity of human marrow stromal progenitors in hemopoiesis. Prog Clin Biol Res 1994; 389:271-80.
32. Jones P, Gardner L, Menage J, Williams GT, Roberts S. Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration. Arthritis Res Ther 2008; 10(4): R86.
33. Ratajczak MZ, Zuba-Surma EK, Shin DM, Ratajczak J, Kucia M. Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity. Exp Gerontol 2008; 43(11):1009-17.
34. Gronthos S, Graves SE, Ohta S, Simmons PJ. The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors. Blood 1994; 84(12): 4164-73.
35. Simmons PJ, Torok-Storb B. Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood 1991; 78(1): 55-62.
36. Gucciardo L, Lories R, Ochsenbein-Kolble N, et al. Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine. BJOG 2009; 116(2): 166-72.
37. Siegel N, Rosner M, Hanneder M, Freilinger A, Hengstschlager M. Human amniotic fluid stem cells: a new perspective. Amino Acids 2008; 35(2):291-3.
38. Serikov V, Hounshell C, Larkin S, et al. A BRIEF COMMUNICATION: Human Term Placenta as a Source of Hematopoietic Cells. Exp Biol Med (Maywood). 2009; 234(7): 813-23.
39. Ilancheran S, Moodley Y, Manuelpillai U. Human fetal membranes: a source of stem cells for tissue regeneration and repair? Placenta 2009; 30(1):2-10.
40. Lubin BH, Eraklis M, Apicelli G. Umbilical cord blood banking. Adv Pediatr 1999; 46: 383-408.
41. Ilancheran S, Michalska A, Peh G, et al. Stem cells derived from human fetal membranes display multilineage differentiation potential. Biol Reprod 2007; 77(3): 577-88.
42. Alviano F, Fossati V, Marchionni C, et al. Term Amniotic membrane is a high throughput source for multipotent Mesenchymal Stem Cells with the ability to differentiate into endothelial cells in vitro. BMC Dev Biol 2007; 7:11.
43. Soncini M, Vertua E, Gibelli L, et al. Isolation and characterization of mesenchymal cells from human fetal membranes. J Tissue Eng Regen Med 2007; 1(4): 296-305.
44. Armitage JO. Bone marrow transplantation. N Engl J Med 1994; 330(12): 827-38.
45. Bailo M, Soncini M, Vertua E, et al. Engraftment potential of human amnion and chorion cells derived from term placenta. Transplantation 2004; 78(10): 1439-48.
46. Li H, Niederkorn JY, Neelam S, et al. Immunosuppressive factors secreted by human amniotic epithelial cells. Invest Ophthalmol Vis Sci 2005; 46(3): 900-7.
47. Chen HJ, Pires RT, Tseng SC. Amniotic membrane transplantation for severe neurotrophic corneal ulcers. Br J Ophthalmol 2000; 84(8): 826-33.
48. Pires RT, Chokshi A, Tseng SC. Amniotic membrane transplantation or conjunctival limbal autograft for limbal stem cell deficiency induced by 5-fluorouracil in glaucoma surgeries. Cornea 2000; 19(3): 284-7.
49. [49] Meller D, Pires RT, Mack RJ, et al. Amniotic membrane transplantation for acute chemical or thermal burns. Ophthalmology 2000; 107(5): 980-9; discussion 90.
50. Goldschlager T, Rosenfeld J, Ghosh P, et al. editors. A Comparison Between Allogeneic Mesenchymal Precursor Cells And Amnion Epithelial Cells In Promoting Cervical Interbody Fusion In An Ovine Model. Congress of Neurological Surgeons, Annual Meeting;; New Orleans 2009.
51. Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 2004; 18(9): 980-2.
52. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5): 861-72.
53. Yu J, Vodyanik M, Smuga-Otto K, et al. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 2007; 318(5858): 1917-20.
54. Kim D, Kim C, Moon J, et al. Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins. Cell Stem Cell 2009: 1-5.
55. Maherali N, Hochedlinger K. Guidelines and Techniques for the Generation of Induced Pluripotent Stem Cells. Cell Stem Cell 2008; 3(6): 595-605.
56. Lian Q, Zhang Y, Zhang J, et al. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice. Circulation 121(9): 1113-23.
57. D'Ippolito G, Diabira S, Howard GA, et al. Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci 2004; 117(Pt 14): 2971-81.
58. Reyes M, Verfaillie CM. Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells. Ann N Y Acad Sci 2001; 938: 231-3; discussion 3-5.
59. Giordano A, Galderisi U, Marino IR. From the laboratory bench to the patient's bedside: an update on clinical trials with mesenchymal stem cells. J Cell Physiol 2007; 211(1): 27-35.
60. Kuci S, Kuci Z, Latifi-Pupovci H, et al. Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine. Curr Stem Cell Res Ther 2009; 4(2): 107-17.
61. Wojakowski W, Kucia M, Kazmierski M, Ratajczak MZ, Tendera M. Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism? Heart 2008; 94(1): 27-33.
62. Blattert TR, Delling G, Dalal PS, et al. Successful transpedicular lumbar interbody fusion by means of a composite of osteogenic protein-1 (rhBMP-7) and hydroxyapatite carrier: a comparison with autograft and hydroxyapatite in the sheep spine. Spine 2002; 27(23): 2697-705.
63. Boden SD, Kang J, Sandhu H, Heller JG. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine 2002; 27(23): 2662-73.
64. Yoon ST, Patel NM. Molecular therapy of the intervertebral disc. Eur Spine J 2006; 15 (Suppl 3): S379-88.
65. Ryu SI, Lim JT, Kim SM, et al. Comparison of the biomechanical stability of dense cancellous allograft with tricortical iliac autograft and fibular allograft for cervical interbody fusion. Eur Spine J 2006; 15(9): 1339-45.
66. Silber JS, Anderson DG, Daffner SD, et al. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 2003; 28(2): 134-9.
67. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105(4): 1815.
68. Tyndall A, Walker U, Cope A, et al. Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005. Arthritis Res Ther 2007; 9(1): 301.
69. Ryan JM, Barry FP, Murphy JM, Mahon BP. Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) 2005; 2: 8.
70. Maccario R, Podestà M, Moretta A, et al. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 2005; 90(4): 516-25.
71. Sonntag VKH, Vollmer DG. Degenerative Disease of the Spine. In: Winn R, editor. Youmans Neurological Surgery. New York: Elsevier; 2006; pp. 4149-50.
72. Mulleman D, Mammou S, Griffoul I, Watier H, Goupille P. Pathophysiology of disk-related sciatica. I.--Evidence supporting a chemical component. Joint Bone Spine 2006; 73(2): 151-8.
73. Mulleman D, Mammou S, Griffoul I, Watier H, Goupille P. Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treatment with TNF-alpha antagonists. Joint Bone Spine 2006; 73(3): 270-7.
74. Chad DA. Lumbar spinal stenosis. Neurol Clin 2007; 25(2): 407-18.
75. Harrop JS, Hanna A, Silva MT, Sharan A. Neurological manifestations of cervical spondylosis: an overview of signs, symptoms, and pathophysiology. Neurosurgery 2007; 60(1 Supp1 1): S14-20.
76. Kumar VGR, Madden C, Rea GL. Cervical Spondylotic Myelopathy. In: Winn R, editor. Youmans Neurological Surgery. New York: Elsevier; 2006; pp. 4447-9.
77. Kandel RA, Chang G, Kluge J, Vunjak-Novakovic G, Kaplan D, Eds. How to tissue engineer an intervertebral disc. World Forum for Spine Research; Kyoto, Japan: AO Spine International 2008.
78. Coppes MH, Marani E, Thomeer RT, Groen GJ. Innervation of painful lumbar discs. Spine. 1997; 22(20):2342-9; discussion 9-50.
79. Peng B, Wu W, Hou S, et al. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br 2005; 87(1): 62-7.
80. Haughton V. Imaging intervertebral disc degeneration. J Bone Joint Surg Am 2006; 88 (Suppl 2): 15-20.
81. Rengachary SS, Balabhadra RS. Black disc disease: a commentary. Neurosurg Focus 2002; 13(2): E14.
82. Videman T, Battié MC, Gibbons LE, et al. Associations between back pain history and lumbar MRI findings. Spine 2003; 28(6):582-8.
83. Sembrano JN, Polly DW, Jr. How often is low back pain not coming from the back? Spine 2009; 34(1): E27-32.
84. Witwer BP, Trost GR. Cervical spondylosis: ventral or dorsal surgery. Neurosurgery 2007; 60(1 Supp1 1): S130-6.
85. Thomé C, Barth M, Scharf J, Schmiedek P. Outcome after lumbar sequestrectomy compared with microdiscectomy: a prospective randomized study. J Neurosurg Spine 2005; 2(3): 271-8.
86. Carragee EJ, Spinnickie AO, Alamin TF, Paragioudakis S. A prospective controlled study of limited versus subtotal posterior discectomy: short-term outcomes in patients with herniated lumbar intervertebral discs and large posterior anular defect. Spine 2006; 31(6): 653-7.
87. Jacobs WC, Anderson PG, Limbeek J, Willems PC, Pavlov P. Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease. Cochrane Database Syst Rev (Online) 2004; (4): CD004958.
88. Irwin ZN, Hilibrand A, Gustavel M, et al. Variation in surgical decision making for degenerative spinal disorders. Part II: cervical spine. Spine 2005; 30(19): 2214-9.
89. Patil PG, Turner DA, Pietrobon R. National trends in surgical procedures for degenerative cervical spine disease: 1990-2000. Neurosurgery 2005; 57(4): 753-8; discussion -8.
90. Deyo RA. Back surgery--who needs it? N Engl J Med 2007; 356(22): 2239-43.
91. Resnick DK, Choudhri TF, Dailey AT, et al. Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 8: lumbar fusion for disc herniation and radiculopathy. J Neurosurg Spine 2005; 2(6): 673-8.
92. Fritzell P, Hägg O, Wessberg P, Nordwall A, Unknown. Volvo Award Winner in Clinical Studies: Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group. Spine 2001; 26(23): 2521-32; discussion 32-4.
93. Weatherley CR, Prickett CF, O'Brien JP. Discogenic pain persisting despite solid posterior fusion. J Bone Joint Surg Br 1986; 68(1): 142-3.
94. Bandopadhayay P, Goldschlager T, Rosenfeld JV. The role of evidence-based medicine in neurosurgery. J Clin Neurosci 2008; 15(4): 373-8.
95. Dowd GC, Wirth FP. Anterior cervical discectomy: is fusion necessary? J Neurosurg 1999; 90(1 Suppl): 8-12.
96. Hauerberg J, Kosteljanetz M, Boge-Rasmussen T, et al. Anterior cervical discectomy with or without fusion with ray titanium cage: a prospective randomized clinical study. Spine 2008; 33(5): 458-64.
97. Martins AN. Anterior cervical discectomy with and without interbody bone graft. J Neurosurg 1976; 44(3): 290-5.
98. Murphy MA, Trimble MB, Piedmonte MR, Kalfas IH. Changes in the cervical foraminal area after anterior discectomy with and without a graft. Neurosurgery 1994; 34(1): 93-6.
99. Rosenorn J, Hansen E, Rosenorn M. Anterior cervical discectomy with and without fusion. A prospective study. J Neurosurg 1983; 59(2): 252-5.
100. van Limbeek J, Jacobs WC, Anderson PG, Pavlov PW. A systematic literature review to identify the best method for a single level anterior cervical interbody fusion. Eur Spine J 2000; 9(2): 129-36.
101. Bartels RH, Donk R, van der Wilt GJ, Grotenhuis JA, Venderink D. Design of the PROCON trial: a prospective, randomized multicenter study comparing cervical anterior discectomy without fusion, with fusion or with arthroplasty. BMC Musculoskelet Disord 2006; 7: 85.
102. Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine 2004; 29(23): 2700-9.
103. Kandel R, Roberts S, Urban JP. Tissue engineering and the intervertebral disc: the challenges. Eur Spine J 2008; 17 Suppl 4: 480-91.
104. Floyd T, Ohnmeiss D. A meta-analysis of autograft versus allograft in anterior cervical fusion. Eur Spine J 2000; 9(5): 398-403.
105. Aho AJ, Hirn M, Aro HT, Heikkila JT, Meurman O. Bone bank service in Finland. Experience of bacteriologic, serologic and clinical results of the Turku Bone Bank 1972-1995. Acta Orthop Scand 1998; 69(6): 559-65.
106. Cho DY, Liau WR, Lee WY, et al. Preliminary experience using a polyetheretherketone (PEEK) cage in the treatment of cervical disc disease. Neurosurgery 2002; 51(6): 1343-49; discussion 9-50.
107. Kulkarni AG, Hee HT, Wong HK. Solis cage (PEEK) for anterior cervical fusion: preliminary radiological results with emphasis on fusion and subsidence. Spine J 2007; 7(2): 205-9.
108. Crawford CH, 3rd, Carreon LY, Djurasovic M, Glassman SD. Lumbar fusion outcomes in patients with rheumatoid arthritis. Eur Spine J 2008; 17(6): 822-5.
109. Mooney V, McDermott KL, Song J. Effects of smoking and maturation on long-term maintenance of lumbar spinal fusion success. J Spinal Disord 1999; 12(5): 380-5.
110. Andersen T, Christensen FB, Laursen M, et al. Smoking as a predictor of negative outcome in lumbar spinal fusion. Spine 2001; 26(23): 2623-8.
111. Lumawig JM, Yamazaki A, Watanabe K. Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion rates. Spine J 2009; 9(5): 343-9.
112. Schuberth JM, DiDomenico LA, Mendicino RW. The utility and effectiveness of bone morphogenetic protein in foot and ankle surgery. J Foot Ankle Surg 2009; 48(3): 309-14.
113. Smith DM, Cooper GM, Mooney MP, Marra KG, Losee JE. Bone morphogenetic protein 2 therapy for craniofacial surgery. J Craniofac Surg 2008; 19(5): 1244-59.
114. Rihn JA, Gates C, Glassman SD, et al. The use of bone morphogenetic protein in lumbar spine surgery. J Bone Joint Surg Am 2008; 90(9): 2014-25.
115. Azari K, Doctor JS, Doll BA, Hollinger JO. Bone morphogenetic proteins A review for cranial and maxillofacial surgery. Oral Maxillofac Surg Clin North Am 2002; 14(1): 1-14.
116. Perri B, Cooper M, Lauryssen C, Anand N. Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine J 2007; 7(2): 235-9.
117. Smucker JD, Rhee JM, Singh K, Yoon ST, Heller JG. Increased swelling complications associated with off-label usage of rhBMP-2 in the anterior cervical spine. Spine 2006; 31(24): 2813-9.
118. FDA. FDA Public Health Notification: Life-threatening Complications Associated with Recombinant Human Bone Morphogenetic Protein in Cervical Spine Fusion. Maryland July, 2008; Available from: http://www.fda.gov/cdrh/safety/070108-rhbmp.html.
119. Goldschlager T, Rosenfeld JV, Young IR, Jenkin G. Anterior cervical discectomy and fusion in the ovine model. J Vis Exp 2009; 32(1548).
120. Goldschlager T, Itescu S, Ghosh P, et al. editors. Allogeneic mesenchymal precursor cells safely and effectively increase the rate and robustness of cervical interbody fusion. Orthopedic Research Society, 55th Annual Meeting; Las Vegas 2009.
121. Goldschlager T, Blecher C, Rosenfeld J, et al. editors. Quantitative analysis of robust cervical interbody fusion induced by allogeneic mesenchymal precursor cells. Spine Society of Australia, Annual Meeting; Brisbane 2009.
122. Goldschlager T, Itescu S, Ghosh P, et al. Cervical Interbody Fusion is Enhanced by Allogeneic Mesenchymal Precursor Cells in an Ovine Model. Spine 2010; in press.
123. Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am 2003; 85-A(8): 1544-52.
124. Goldschlager T. A Phase 1b/2a, Randomized, Double-Blinded, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuseTM when Combined with MasterGraftTM Granules in Subjects Undergoing Multi-Level Anterior Cervical Discectomy Model. Approval number: ACTRN126090010492682009; Available from: http://www.ANZCTR.org.au/ACTRN12609001049268.aspx.
125. NIH. Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF), NCT00549913. clinicaltrial.gov; 2009; Available from: http://clinicaltrials.gov/ct2/show/NCT00549913.
126. Blumenthal SL, Baker J, Dossett A, Selby DK. The role of anterior lumbar fusion for internal disc disruption. Spine 1988; 13(5): 566-9.
127. Xie JC, Hurlbert RJ. Discectomy versus discectomy with fusion versus discectomy with fusion and instrumentation: a prospective randomized study. Neurosurgery 2007; 61(1): 107-16; discussion 16-7.
128. Vaccaro AR, Whang PG, Patel T, et al. The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study. Spine J 2008; 8(3): 457-65.
129. Vaccaro AR, Patel T, Fischgrund J, et al. A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 2003; 12(5): 495-500.
130. Nakajima T, Iizuka H, Tsutsumi S, Kayakabe M, Takagishi K. Evaluation of posterolateral spinal fusion using mesenchymal stem cells: differences with or without osteogenic differentiation. Spine 2007; 32(22): 2432-6.
131. Trials C. Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF), NCT00549913. clinicaltrial.gov; 2009; Available from: http://clinicaltrials.gov/ct2/show/NCT00549913.
132. Koebbe CJ, Maroon JC, Abla A, El-Kadi H, Bost J. Lumbar microdiscectomy: a historical perspective and current technical considerations. Neurosurg Focus 2002; 13(2): E3.
133. Moore RJ, Vernon-Roberts B, Fraser RD, Osti OL, Schembri M. The origin and fate of herniated lumbar intervertebral disc tissue. Spine 1996; 21(18): 2149-55.
134. Schaller B. Failed back surgery syndrome: the role of symptomatic segmental single-level instability after lumbar microdiscectomy. Eur Spine J 2004; 13(3): 193-8.
135. Yorimitsu E, Chiba K, Toyama Y, Hirabayashi K. Long-term outcomes of standard discectomy for lumbar disc herniation: a follow-up study of more than 10 years. Spine 2001; 26(6): 652-7.
136. McGirt MJ, Ambrossi GL, Datoo G, et al. Recurrent disc herniation and long-term back pain after primary lumbar discectomy: review of outcomes reported for limited versus aggressive disc removal. Neurosurgery 2009; 64(2): 338-44; discussion 44-5.
137. Sato M, Asazuma T, Ishihara M, et al. An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering method. Spine 2003; 28(6): 548-53.
138. Hamilton DJ, Seguin CA, Wang J, Pilliar RM, Kandel RA. Formation of a nucleus pulposus-cartilage endplate construct in vitro. Biomaterials 2006; 27(3): 397-405.
139. Gruber HE, Hoelscher GL, Leslie K, Ingram JA, Hanley EN, Jr. Three-dimensional culture of human disc cells within agarose or a collagen sponge: assessment of proteoglycan production. Biomaterials 2006; 27(3): 371-6.
140. Gruber HE, Leslie K, Ingram J, Norton HJ, Hanley EN. Cell-based tissue engineering for the intervertebral disc: in vitro studies of human disc cell gene expression and matrix production within selected cell carriers. Spine J 2004; 4(1): 44-55.
141. Mizuno H, Roy AK, Vacanti CA, et al. Tissue-engineered composites of anulus fibrosus and nucleus pulposus for intervertebral disc replacement. Spine 2004; 29(12): 1290-7; discussion 7-8.
142. Neidlinger-Wilke C, Wurtz K, Liedert A, et al. A threedimensional collagen matrix as a suitable culture system for the comparison of cyclic strain and hydrostatic pressure effects on intervertebral disc cells. J Neurosurg Spine 2005; 2(4): 457-65.
143. Desai BJ, Gruber HE, Hanley EN, Jr. The influence of Matrigel or growth factor reduced Matrigel on human intervertebral disc cell growth and proliferation. Histol Histopathol 1999; 14(2): 359-68.
144. Gruber HE, Leslie K, Ingram J, et al. Colony formation and matrix production by human anulus cells: modulation in three-dimensional culture. Spine 2004; 29(13): E267-74.
145. Steck E, Bertram H, Abel R, et al. Induction of intervertebral disclike cells from adult mesenchymal stem cells. Stem Cells (Dayton, Ohio) 2005; 23(3): 403-11.
146. Le Visage C, Kim SW, Tateno K, et al. Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis. Spine 2006; 31(18): 2036-42.
147. Wei A, Chung SA, Tao H, et al. Differentiation of Rodent Bone Marrow Mesenchymal Stem Cells into Intervertebral Disc-Like Cells Following Co-Culture with Rat Disc Tissue. Tissue Eng Part A 2009; 15(9): 2581-95.
148. Meisel H, Ganey T, Hutton W, et al. Clinical experience in cellbased therapeutics: intervention and outcome. Eur Spine J 2006; 15 Suppl 3: S397-405.
149. Meisel H, Siodla V, Ganey T, et al. Clinical experience in cellbased therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng 2007; 24(1): 5-21.
150. Ganey TM, Meisel HJ. A potential role for cell-based therapeutics in the treatment of intervertebral disc herniation. Eur Spine J 2002; 11 (Suppl 2): S206-14.
151. Hohaus C, Ganey TM, Minkus Y, Meisel HJ. Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J 2008; 17 Suppl 4: 492-503.
152. Ghosh P, Itescu S, Moore R, et al. Eds. Injection of allogeneic immunoselected Stro-3+ mesenchymal precursor stem into lumbar intervertebral discs attenuates degeneration and promotes the restoration of the disc extracellular matrix. An experimental study in an ovine model of disc degeneration. Osteoarthritis Research Society International; Montreal 2009.
153. Hilibrand AS, Carlson GD, Palumbo MA, Jones PK, Bohlman HH. Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior cervical arthrodesis. J Bone Joint Surg Am 1999; 81(4): 519-28.
154. Auerbach JD, Jones KJ, Fras CI, et al. The prevalence of indications and contraindications to cervical total disc replacement. Spine J 2008; 8(5): 711-6.
155. Bertagnoli R, Yue JJ, Pfeiffer F, et al. Early results after ProDisc-C cervical disc replacement. J Neurosurg Spine 2005; 2(4): 403-10.
156. Coric D, Finger F, Boltes P. Prospective randomized controlled study of the Bryan Cervical Disc: early clinical results from a single investigational site. J Neurosurg Spine 2006; 4(1): 31-5.
157. Hacker R. Cervical disc arthroplasty: a controlled randomized prospective study with intermediate follow-up results. Invited submission from the joint section meeting on disorders of the spine and peripheral nerves. J Neurosurg Spine 2005; 3(6): 424-8.
158. Porchet F, Metcalf N. Clinical outcomes with the Prestige II cervical disc: preliminary results from a prospective randomized clinical trial. Neurosurg Focus 2004; 17(3): E6.
159. Ruan D, He Q, Ding Y, et al. Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study. Lancet 2007; 369(9566): 993-9.
160. Goldschlager T, Ghosh P, Wu J, et al. Regeneration of the cervical intervertebral disc Part 1: Enhanced proliferation and chondrogenic differentiation of Mesenchymal Precursor Stem Cells (MPC) cultured in collagen sponges in the presence of Pentosan Polysulfate (PPS). Submitted 2009.
161. Goldschlager T, Ghosh P, Zannettino A, et al. Cervical Motion Preservation using Mesenchymal Progenitor Cells and a novel chondrogenic agent, Pentosan Polysulfate - A preliminary study in an ovine model. Neurosurg Focus 2010; in press.
162. Abbed KM, Coumans JV. Cervical radiculopathy: pathophysiology, presentation, and clinical evaluation. Neurosurgery 2007; 60 (1 Supp1 1): S28-34.
163. Melrose J, Roberts S, Smith S, Menage J, Ghosh P. Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine 2002; 27(12): 1278-85.
164. Finch P. Technology Insight: imaging of low back pain. Nat Clin Pract Rheumatol 2006; 2(10): 554-61.
165. Derby R, Kim BJ, Lee SH, et al. Comparison of discographic findings in asymptomatic subject discs and the negative discs of chronic LBP patients: can discography distinguish asymptomatic discs among morphologically abnormal discs? Spine J 2005; 5(4): 389-94.
166. Buenaventura RM, Shah RV, Patel V, Benyamin R, Singh V. Systematic review of discography as a diagnostic test for spinal pain: an update. Pain Physician 2007; 10(1): 147-64.
167. Jensen MC, Brant-Zawadzki MN, Obuchowski N, et al. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med 1994; 331(2): 69-73.
168. Freemont AJ, Peacock TE, Goupille P, et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997; 350(9072): 178-81.