Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation

International Journal of Cardiology

Volumn 145, Issue 2, 2010, Pages 316-317

  Boldt, Leif Hendrik ^a   Posch, Maximilian G ^a   Perrot, Andreas ^a   Polotzki, Michael ^a   Rolf, Sascha ^a   Parwani, Abdul S ^a   Huemer, Martin ^a   Wutzler, Alexander ^a   Özcelik, Cemil ^a   Haverkamp, Wilhelm ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Atrial fibrillation; Genetics; Mutation; NKX2 5; PITX2

Indexed keywords

GENOMIC DNA; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR PITX2;

ADULT; ATRIOVENTRICULAR BLOCK; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SCREENING; DNA SEQUENCE; FEMALE; GENETIC VARIABILITY; HEART ATRIUM FIBRILLATION; HEART ATRIUM SEPTUM DEFECT; HUMAN; IDIOPATHIC DISEASE; INTRON; LETTER; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PRIORITY JOURNAL;

EID: 78650004175     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2009.11.023     Document Type: Article

References (16)

1. C.S. Fox, H. Parise, and R.B. D'Agostino Sr. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring JAMA 291 2004 2851 2855
2. P.T. Ellinor, D.M. Yoerger, J.N. Ruskin, and C.A. MacRae Familial aggregation in lone atrial fibrillation Hum Genet 118 2005 179 184
3. M. Haïssaguerre, P. Jaïs, and D.C. Shah Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins N Engl J Med 339 1998 659 666
4. D.F. Gudbjartsson, D.O. Arnar, and A. Helgadottir Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 19 2007 353 357
5. S. Kääb, D. Darbar, and C. van Noord Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation Eur Heart J 30 2009 813 819
6. M.K. Chung, D.R. van Wagoner, and J.D. Smith Significant single nucleotide polymorphism associated with atrial fibrillation located on chromosome 4q25 in a whole genome association study and association with left atrial gene expression Abstract, Scientific Sessions American Heart Association 2008 Circulation vol. 118 2008 S 882
7. M.T. Mommersteeg, N.A. Brown, and O.W. Prall Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium Circ Res 26 2007 902 909
8. M.T. Mommersteeg, W.M. Hoogaars, and O.W. Prall Molecular pathway for the localized formation of the sinoatrial node Circ Res 16 2007 354 362
9. J.J. Schott, D.W. Benson, and C.T. Basson Congenital heart disease caused by mutations in the transcription factor NKX2-5 Science 281 1998 108 111
10. L. Gioli-Pereira, A.C. Pereira, S.M. Mesquita, J. Xavier-Neto, A.A. Lopes, and J.E. Krieger NKX2.5 mutations in patients with non-syndromic congenital heart disease Int J Cardiol 2008 10.1016/j.ijcard.2008.08.035
11. M.M. Balci, and R. Akdemir NKX2.5 mutations and congenital heart disease: Is it a marker of cardiac anomalies? Int J Cardiol 2009 10.1016/j.ijcard.2009. 01.024
12. I. Gutierrez-Roelens, L. De Roy, and C. Ovaert A novel CSX/NKX2-5 mutation causes autosomal-dominant AV block: are atrial fibrillation and syncopes part of the phenotype? Eur J Hum Genet 14 2006 1313 1316
13. M.G. Posch, A. Perrot, and C. Geier Genetic deletion of arginine 14 in phospholamban causes dilated cardiomyopathy with attenuated electrocardiographic R amplitudes Heart Rhythm 6 2009 480 486
14. W.G. Fairbrother, D. Holste, C.B. Burge, and P.A. Sharp Single nucleotide polymorphism-based validation of exonic splicing enhancers PLoS Biol 2 2004 E268
15. M.G. Posch, A. Perrot, and K. Schmitt Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects Am J Med Genet A 146 2008 251 253
16. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150