Outcomes in diabetic and nondiabetic patients treated with everolimus- or paclitaxel-eluting stents: Results from the SPIRIT IV clinical trial (Clinical Evaluation of the XIENCE v Everolimus Eluting Coronary Stent System)

Journal of the American College of Cardiology

Volumn 56, Issue 25, 2010, Pages 2084-2089

  Kereiakes, Dean J ^a   Cutlip, Donald E ^b   Applegate, Robert J ^c   Wang, John ^d   Yaqub, Manejeh ^e   Sood, Poornima ^e   Su, Xiaolu ^e   Su, Guoping ^e   Farhat, Naim ^f   Rizvi, Ali ^g   Simonton, Charles A ^e   Sudhir, Krishnankutty ^e   Stone, Gregg W ^h  

^a The Carl & Edyth Lindner Center for Research & Education   (United States)

^b HARVARD CLINICAL RESEARCH INSTITUTE   (United States)

^c WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^d UNION MEMORIAL HOSPITAL   (United States)

^e ABBOTT VASCULAR   (United States)

^f EMH Regional Medical Center   (United States)

^g Women's Specialists of Houston   (United States)

^h NewYork Presbyterian Hospital   (United States)

Author keywords

diabetes; drug eluting stent(s); everolimus; majoradverse cardiac event(s)

Indexed keywords

EVEROLIMUS; INSULIN; PACLITAXEL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY STENT; DIABETES MELLITUS; DIABETIC PATIENT; DRUG EFFICACY; DRUG ELUTING STENT; DRUG SAFETY; DRUG TREATMENT FAILURE; DRUG USE; FEMALE; HEART DEATH; HEART INFARCTION; HEART MUSCLE REVASCULARIZATION; HUMAN; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERCUTANEOUS CORONARY INTERVENTION; PREDICTOR VARIABLE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVASCULARIZATION; SINGLE BLIND PROCEDURE; STENT THROMBOSIS; TREATMENT OUTCOME;

AGED; ANGIOPLASTY, BALLOON, CORONARY; CORONARY ARTERY DISEASE; DIABETIC ANGIOPATHIES; DRUG-ELUTING STENTS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PACLITAXEL; PROSPECTIVE STUDIES; SIROLIMUS; TREATMENT FAILURE;

EID: 78650002551     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.10.006     Document Type: Article

References (22)

1. V. Mathew, and D.R. Holmes Outcomes in diabetics undergoing revascularization: the long and the short of it J Am Coll Cardiol 40 2002 424 427
2. E. Van Belle, M. Perie, and D. Braune Effects of coronary stenting on vessel patency and long-term clinical outcome after percutaneous coronary revascularization in diabetic patients J Am Coll Cardiol 40 2002 410 417
3. P.R. Moreno, P. Murcia, and I.F. Palacios Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus Circulation 102 2000 180 184
4. S.C. Smith Jr., D. Faxon, and W. Cascio Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group VI: revascularization in diabetic patients Circulation 105 2002 e165 e169
5. J.B. Hermiller, A. Raizner, and L. Cannon Outcomes with the polymer-based paclitaxel-eluting TAXUS stent in patients with diabetes mellitus: the TAXUS-IV trial J Am Coll Cardiol 45 2005 1172 1179
6. I. Moussa, M.B. Leon, and D.S. Baim Impact of sirolimus-eluting stents on outcome in diabetic patients: a SIRIUS (SIRolImUS-coated Bx Velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions) substudy Circulation 109 2004 2273 2278
7. R. Iijima, G. Ndrepepa, and J. Mehilli Impact of diabetes mellitus on long-term outcomes in the drug-eluting stent era Am Heart J 154 2007 688 693
8. A.J. Kirtane, S.G. Ellis, and K.D. Dawkins Paclitaxel-eluting coronary stents in patients with diabetes mellitus: pooled analysis from 5 randomized trials J Am Coll Cardiol 51 2008 708 715
9. A. Caixeta, R. Mehran, and E. Nikolsky Four-year clinical outcomes after drug-eluting and bare-metal stents in patients with diabetes mellitus: pooled analysis from 10 randomized clinical trials J Am Coll Cardiol 53 2009 A2
10. D.T. Ko, M. Chiu, P.C. Austin, J. Bowen, E.A. Cohen, and J.V. Tu Safety and effectiveness of drug-eluting stents among diabetic patients: a propensity analysis Am Heart J 156 2008 125 134
11. S.R. Mulukutla, H.A. Vlachos, and O.C. Marroquin Impact of drug-eluting stents among insulin-treated diabetic patients: a report from the National Heart, Lung, and Blood Institute Dynamic Registry J Am Coll Cardiol Intv 1 2008 139 147
12. A. Dibra, A. Kastrati, and J. Mehilli Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients N Engl J Med 353 2005 663 670
13. E. Mahmud, J.A. Ormiston, and M.A. Turco TAXUS Liberte attenuates the risk of restenosis in patients with medically treated diabetes mellitus: results from the TAXUS ATLAS program J Am Coll Cardiol Intv 2 2009 240 252
14. G.W. Stone, M. Midei, and W. Newman Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease: a randomized trial JAMA 299 2008 1903 1913
15. Y. Mitsuuchi, S.W. Johnson, M. Selvakumaran, S.J. Williams, T.C. Hamilton, and J.R. Testa The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel Cancer Res 60 2000 5390 5394
16. E. Nikolsky, A.J. Lansky, and K. Sudhir SPIRIT IV trial design: a large-scale randomized comparison of everolimus-eluting stents and paclitaxel-eluting stents in patients with coronary artery disease Am Heart J 158 2009 520 526 e2
17. G.W. Stone, A. Rizvi, and W. Newman Everolimus-eluting versus paclitaxel-eluting stents in coronary artery disease N Engl J Med 362 2010 1663 1674
18. D.E. Cutlip, S. Windecker, and R. Mehran Clinical end points in coronary stent trials: a case for standardized definitions Circulation 115 2007 2344 2351
19. E. Grube SPIRIT V Diabetic RCT: 9 Month Angiographic and 1 Year Clinical Follow-up Paper presented at: EuroPCR; Paris, France; May 25, 2010 http://www.tctmd.com/show.aspx?id=90196 Accessed October 25, 2010
20. E. Kedhi, K.S. Joesoef, and E. McFadden Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice (COMPARE): a randomised trial Lancet 375 2010 201 209
21. M. Joner, G. Nakazawa, and A.V. Finn Endothelial cell recovery between comparator polymer-based drug-eluting stents J Am Coll Cardiol 52 2008 333 342
22. C.M. Nickson, P.J. Doherty, and R.L. Williams Novel polymeric coatings with the potential to control in-stent restenosisan in vitro study J Biomater Appl 24 2010 437 452