Brain metastases from melanoma: Is there a role for concurrent temozolomide in addition to whole brain radiation therapy?

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 33, Issue 6, 2010, Pages 633-636

  Schild, Steven E ^a   Behl, Deepti ^b   Markovic, Svetomir N ^b   Brown, Paul D ^a   Sande, Jonathan R ^c   Deming, Richard L ^d   Rowland Jr , Kendrith M ^e   Bearden, James D ^f  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC ROCHESTER   (United States)

^c Duluth CCOP   (United States)

^d Iowa Oncology Research Association CCOP   (United States)

^e Carle Cancer Center CCOP   (United States)

^f Upstate Carolina CCOP   (United States)

Author keywords

Brain metastases; Combined modality therapy; Melanoma; Temozolomide; Whole brain radiotherapy

Indexed keywords

TEMOZOLOMIDE;

ADULT; ARTICLE; BRAIN METASTASIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MELANOMA; MULTIPLE CYCLE TREATMENT; PROGNOSIS; RADIATION DOSE FRACTIONATION;

ADMINISTRATION, ORAL; AGED; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; COHORT STUDIES; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; DACARBAZINE; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MELANOMA; MIDDLE AGED; RADIOTHERAPY DOSAGE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SKIN NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 78649998499     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0b013e3181c4c54b     Document Type: Article

References (23)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71-96.
2. Patel JK, Didolkar MS, Pickren JW, et al. Metastatic pattern of malignant melanoma. A study of 216 autopsy cases. Am J Surg. 1978;135:807-810.
3. Rades D, Bohlen G, Dunst J, et al. Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases. Strahlenther Onkol. 2008;184:30-35.
4. Rades D, Bohlen G, Pluemer A, et al. Stereotactic radiosurgery alone versus resection plus whole-brain radiotherapy for 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients. Cancer. 2007;109:2515-2521. (Pubitemid 46906471)
5. Carella RJ, Gelber R, Hendrickson F, et al. Value of radiation therapy in the management of patients with cerebral metastases from malignant melanoma: Radiation Therapy Oncology Group Brain Metastases Study I and II. Cancer. 1980;45:679-683.
6. Quirt I, Verma S, Petrella T, et al. Temozolomide for the treatment of metastatic melanoma: A systematic review. Oncologist. 2007;12:1114-1123. (Pubitemid 350007023)
7. Rofstad EK, Wahl A, Brustad T. Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens. Cancer Res. 1987;47:106-110.
8. Diener-West M, Earle JD, Fine SL, et al. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: initial mortality findings. COMS Report No. 18. Arch Ophthalmol. 2001;119:969-982.
9. Harwood AR. Conventional fractionated radiotherapy for 51 patients with lentigo maligna and lentigo maligna melanoma. Int J Radiat Oncol Biol Phys. 1983;9:1019-1021.
10. Olivier KR, Schild SE, Morris CG, et al. A higher radiotherapy dose is associated with more durable palliation and longer survival in patients with metastatic melanoma. Cancer. 2007;110:1791-1795.
11. Ballo MT, Ang KK. Radiation therapy for malignant melanoma. Surg Clin North Am. 2003;83:323-342.
12. Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: A randomized trial. JAMA.1998;280:1485-1489.
13. Vecht CJ, Haaxma-Reiche H, Noordijk EM, et al. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Ann Neurol.1993;33:583-590.
14. Mintz AH, Kestle J, Rathbone MP, et al. A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer. 1996;78:1470-1476.
15. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet. 2004;363:1665-1672.
16. Margolin K, Atkins B, Thompson A, et al. Temozolomide and whole brain irradiation in melanoma metastatic to the brain: A phase II trial of the Cytokine Working Group. J Cancer Res Clin Oncol. 2002;128:214-218.
17. Rades D, Heisterkamp C, Huttenlocher S, et al. Dose escalation of wholebrain radiotherapy for brain metastases from melanoma. Int J Radiat Oncol Biol Phys. 2009 Sep 2. [Epub ahead of print]PMID: 19733017 [PubMed - as supplied by publisher]
18. Hofmann M, Kiecker F, Wurm R, et al. Temozolomide with or without radiotherapy in melanoma with unresectable brain metastases. J Neurooncol. 2006;76:59-64.
19. Conill C, Jorcano S, Domingo-Domenech J, et al. Whole brain irradiation and temozolomide based chemotherapy in melanoma brain metastases. Clin Transl Oncol. 2006;8:266-270.
20. Verger E, Gil M, Yaya R, et al. Temozolomide and concomitant whole brain radiotherapy in patients with brain metastases: A phase II randomized trial. Int J Radiat Oncol Biol Phys. 2005;61:185-191.
21. Atkins MB, Sosman JA, Agarwala S, et al. Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma. Cancer. 2008;113:2139-2145.
22. Agarwala SS, Kirkwood JM, Gore M, et al. Temozolomide for the treatment of brain metastases associated with metastatic melanoma: A phase II study. J Clin Oncol. 2004;22:2101-2107.
23. Perez DG, Suman V, Amatruda T, et al. Phase II trial of carboplatin, weekly paclitaxel, and biweekly bevacizumab in patients with unresectable stage IV melanoma. J Clin Oncol. 2007;25(suppl 18): A-8560, 487s.