Drug-induced hemolytic anemia and thrombocytopenia associated with alterations of cell membrane lipids and acanthocyte formation

Toxicologic Pathology

Volumn 38, Issue 6, 2010, Pages 907-922

  Poulet, Frederique M ^a   Penraat, Kelley ^b   Collins, Nathaniel ^a   Evans, Ellen ^a   Thackaberry, Evan ^a   Manfra, Denise ^a   Engstrom, Laura ^a   Geissler, Richard ^a   Geraci Erck, Maria ^a   Frugone, Carlos ^a   Abutarif, Malaz ^c   Fine, Jay S ^d   Peterson, Brianna L ^e,f   Cummings, Brian S ^e   Johnson, Robert C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Alpha Omega Veterinary Consultant Services   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d University of Georgia ^*

^e Forensic Laboratory Services Bureau   (United States)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

acanthocytosis; CXCR3 receptor antagonist; erythrocyte; hemolytic anemia; platelet; rat; thrombocytopenia

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR3; CHOLESTEROL; HEMOSIDERIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MEMBRANE LIPID; PHOSPHATIDYLCHOLINE; SCH 900875; SPHINGOMYELIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ACANTHOCYTOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DESTRUCTION; CELL STRUCTURE; CELL TYPE; DISEASE SEVERITY; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; EX VIVO STUDY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; HEMOLYTIC ANEMIA; HYPERCHOLESTEROLEMIA; INFLAMMATION; LIPID ANALYSIS; LIPID COMPOSITION; MACROPHAGE; MALE; MOUSE; NONHUMAN; OSMOTIC FRAGILITY; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SINUS CONGESTION; SPLENOMEGALY; T LYMPHOCYTE ACTIVATION; THROMBOCYTE; THROMBOCYTE MEMBRANE; THROMBOCYTOPENIA;

ACANTHOCYTES; ANEMIA, HEMOLYTIC; ANIMALS; BLOOD PLATELETS; CHOLESTEROL; ERYTHROCYTE MEMBRANE; HEMATOPOIESIS, EXTRAMEDULLARY; HYPERCHOLESTEROLEMIA; MEMBRANE LIPIDS; OSMOTIC FRAGILITY; PHOSPHATIDYLCHOLINES; RATS; RECEPTORS, CXCR3; SPHINGOMYELINS; SPLEEN; THROMBOCYTOPENIA; TRIGLYCERIDES;

RATTUS;

EID: 78649972803     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310378865     Document Type: Article

References (37)

1. Betticher, D.C., and Pugin, P. (1991). Hypothyroidie et acanthocytes: importance diagnostique du frottis sanguin. Schweiz Med Wschr 121, 1127-32.
2. Bligh, E.G., and Dyer, W.J. (1959). A rapid method of total lipid extraction and purification. J Biochem Physiol 37, 911-7.
3. Bloom, J.C., and Brandt, J.T. (2008). Toxic responses of the blood. In Casarett and Doull's Toxicology: The Basic Science of Poisons (C. D. Klaassen, ed.), 7 th ed., pp. 455-84. McGraw-Hill, New York, NY.
4. Christopher, M.M., and Lee, S.E. (1994). Red cell morphologic alterations in cats with hepatic disease. Vet Clin Pathol 23, 7-12.
5. Cooper, R.A. (1978). Influence of increased membrane cholesterol on membrane fluidity and cell function in human red blood cells. J Supramolecular Structure 8, 413-30.
6. Cooper, R.A., Arner, E.C., Wiley, J.S., and Shattil, S.J. (1975). Modification of red cell membrane structure by cholesterol-rich lipid dispersions. J Clin Invest 55, 115-26.
7. Cooper, R.A., Durocher, J.R., and Leslie, M.H. (1977). Decreased fluidity of red cell membrane lipids in abetalipoproteinemia. J Clin Invest 60, 115-21.
8. Cooper, R.A., Leslie, M.H., Knight, D., and Detweiler, D.K. (1980). Red cell cholesterol enrichment and spur cell anemia in dogs fed a cholesterol-enriched, atherogenic diet. J Lipid Res 21, 1082-8.
9. Doll, D.C. (1982). Surface morphology of platelets in spur-cell anemia. Hum Pathol 13, 671-72.
10. Filippini A., Villa G., Corrocher R., De Franceschi L. (2007). Acute hemolytic anemia with acanthocytosis associated with high-dose misopro stol for medical abortion. Ann Emerg Med 50, 289-91.
11. Gallagher, P.G., and Jarolim, P. (2000). Red cell membrane disorders. In Hematology: Basic Principles and Practice (R. Hoffman, E. J. Benz Jr., S. J. Shattil, B. Furie, H. J. Cohen, L. E. Silberstein, and P. McGlave, eds.). 3 rd ed., pp. 576-610. Churchill Livingstone, Philadelphia, PA.
12. Gelberg, H., and Stackhouse, L.L. (1977). Three cases of canine acanthocytosis associated with splenic neoplasia. Vet Med Small Anim Clin 72, 1183-4.
13. Hirsch, V.M., Jacobsen, J., and Mills, J.H.L. (1981). A retrospective study of canine hemangiosarcoma and its association with acanthocytosis. Can Vet J 22, 152-5.
14. Iida, H., Takashima, Y., Maeda, S., Sekiya, T., Kawade, M., Kawamura, M., Okano, Y., and Nozawa, Y. (1984). Alterations in erythrocyte membrane lipids in abetalipoproteinemia: phospholipid and fatty acyl composition. Biochem Med 32, 79-87.
15. Itaya, K., and Ui, M. (1966). A new micromethod for the colorimetric determination of inorganic phosphate. Clin Chim Acta 14, 361-6.
16. Kay, J., and Stricker, R.B. (1983). Hematologic and immunologic abnormalities in anorexia nervosa. South Med J 76, 1008-10.
17. Kile, B.T. (2009). The role of intrinsic apoptosis pathway in platelet life and death. J Thromb Haemost 7 (Suppl. 1). 214-7.
18. Kunkel, E.J., Boisvert, J., Murphy, K., Vierra, M.A., Genovese, M.C., Wardlaw, A.J., Greenberg, H.B., Hodge, M.R., Wu, L., Butcher, E.C., and Campbell, J.J. (2002). Expression of the chemokine receptors CCR4, CCR5 and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol 160, 347-55.
19. Mahad, D.J., Lawry, J., Howell, S.J., and Woodroffe, M.N. (2003). Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Mult Scler 9, 189-98.
20. Mason, K.D., Carpinelli, M.R., Fletcher, J.I., Collinge, J.E., Hilton, A.A., Ellis, S., Kelly, P.N., Ekert, P.G., Metcalf, D., Roberts, A.W., Huang, D.C.S., and Kile, B.T. (2007). Programmed anuclear cell death delimits platelet life span. Cell 128, 1173-86.
21. Mohan, K., Cordeiro, E., Vaci, M., McMaster, C., and Issekutz, T.B. (2005). CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Eur J Immunol 35, 1702-11.
22. Mohandas, N., and Chasis, J.A. (1993). Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids. Semin Hematol 30, 171-92.
23. National Research Council (1996). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
24. Ng, C.Y., and Mills, J.N. (1985). Clinical and haematological features of haemangiosarcoma in dogs. Aust Vet J 62, 1-4.
25. Ohba, Y., Takasu, M., Nishii, N., Hosoda, I., Kitoh, K., Matsumoto, I., Zhang, C., and Kitagawa, H. (2007). Japanese black cattle with orotic aciduria detected by gas-chromatography/mass-spectrometry. J vet Med Sci 69, 313-6.
26. Qin, S., Rottman, J.B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A.E., Moser, B., and Mackay, C.R. (1998). The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101, 746.
27. Quigley, K.A., Chelack, B.J., Haines, D.M., and Jackson, M.L. (2001). Application of a direct flow cytometric erythrocyte immunofluorescence assay in dogs with immune-mediated hemolytic anemia and comparison to the direct antiglobulin test. J Vet Diagn Invest 13, 297-300.
28. Rottman, J.B., Smith, T.L., Ganley, K.G., Kikuchi, T., and Krueger, J.G. (2001). Potential role of the chemokine receptors CXCR3, CCR4 and the integrin αEβ7 in the pathogenesis of psoriasis vulgaris. Lab Invest 81, 335-47.
29. Saldanha, T., Sawaya, A.C., Eberlin, M.N., and Bragagnolo, N. (2006). HPLC separation and determination of 12 cholesterol oxidation products in fish: comparative study of RI, UV, and APCI-MS detectors. J Agric Food Chem 54, 4107-13.
30. Segerer, S., Banas, B., Wornie Mm Schmid, H., Cohen, C.D., Kretzler, M., Mack, M., Kiss, E., Nelson, P.J., Schlondorff, D., and Grone, H.J. (2004). CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. Am J Pathol 164, 635-49.
31. Shull, R.M., Bunch, S.E., Maribei, J., and Spaulding, G.L. (1978). Spur cell anemia in a dog. JAVMA 173, 978-82.
32. Taguchi, R., Hayakawa, J., Takeuchi, Y., and Ishida, M. (2000). Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom 35, 953-66.
33. Ulibarrena, C., Vecino, A., and Cesar, J.M. (1994). Red cell lipid abnormalities in acquired acanthocytosis are extended to platelets. Br J Haematol 87, 614-6.
34. Vandendries, E.R., and Drews, R.E. (2006). Drug-associated disease: hematologic dysfunction. Crit Care Clin 22, 347-55.
35. Warkentin, T.E., and Kelton, J.G. (2000). Thrombocytopenia due to platelet destruction and hypersplenism. In Hematology: Basic Principles and Practice (R. Hoffman, E. J. Benz Jr., S. J. Shattil, B. Furie, H. J. Cohen, L. E. Silberstein, and P. McGlave, eds.), 3 rd ed., pp. 2138-54. Churchill Livingstone, Philadelphia, PA.
36. Weiss, D.J., Kristensen, A., and Papenfuss, N. (1993). Quantitative evaluation of irregularly spiculated red blood cells in the dog. Vet Clin Pathol 22, 117-21.
37. Zieve, L. (1958). Jaundice, hyperlipidemia and hemolytic anemia: a heretofore unrecognized syndrome associated with fatty liver and cirrhosis. Ann Intern Med 48, 471-95.