First report of lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome with pancreatitis

Annals of Pharmacotherapy

Volumn 44, Issue 12, 2010, Pages 1998-2000

  Roquin, Guillaume ^a   Peres, Marine ^b   Lerolle, Nicolas ^c   Dib, Nina ^a,d   Mercat, Alain ^c   Croue, Anne ^a   Augusto, Jean François ^c  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b Universite d'Angers   (France)

^c UNIVERSITÉ D'ANGERS   (France)

^d Service d'Hépato Gastro Entérologie   (France)

Author keywords

Adverse drug reaction; Dress syndrome; Human herpesvirus 6; Lamotrigine; Pancreatitis

Indexed keywords

LAMOTRIGINE; PREDNISONE;

ACUTE ABDOMEN; AGED; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DETERIORATION; DRESS SYNDROME; DRUG DOSE INCREASE; DRUG WITHDRAWAL; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; INTENSIVE CARE; MALE; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; TONIC CLONIC SEIZURE;

AGED; DRUG ERUPTIONS; EOSINOPHILIA; EXANTHEMA; HUMANS; MALE; PANCREATITIS; SYNDROME; TRIAZINES;

EID: 78649953609     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1P350     Document Type: Article

References (14)

1. Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg 1996;15:250-7.
2. Stefan H, Feuerstein TJ. Novel anticonvulsant drugs. Pharmacol Ther 2007;113:165-83.
3. Shawcross D, Auzinger G. Lamotrigine and the risk of fulminant hepatic failure. Lancet 2008;371:649-50.
4. Knowles SR, Shapiro LE, Shear NH. Anticonvulsant hypersensitivity syndrome: incidence, prevention and management. Drug Saf 1999;21:489-501.
5. Amante MF, Filippini AV, Cejas N, et al. DRESS syndrome and fulminant hepatic failure induced by lamotrigine. Ann Hepatol 2009; 8:75-7.
6. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int 2006;55:1-8.
7. Tohyama M, Hashimoto K, Yasukawa M, et al. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. Br J Dermatol 2007;157:934-40. (Pubitemid 47583515)
8. Descamps V, Valance A, Edlinger C, et al. Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms. Arch Dermatol 2001;137:301-4. (Pubitemid 32240782)
9. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45. (Pubitemid 12149145)
10. Descamps V, Mahe E, Houhou N, et al. Drug-induced hypersensitivity syndrome associated with Epstein-Barr virus infection. Br J Dermatol 2003;148:1032-4. (Pubitemid 36750800)
11. Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus- 6 as a causal agent for exanthem subitum. Lancet 1988;1:1065-7.
12. de Pagter PJ, Schuurman R, Meijer E, van Baarle D, Sanders EA, Boelens JJ. Human herpesvirus type 6 reactivation after haematopoietic stem cell transplantation. J Clin Virol 2008;43:361-6.
13. Nwogbe B, Ferié J, Smith H, Gunawardena I, Dhatariya K. Significant lamotrigine overdose associated with acute pancreatitis. J R Soc Med 2009;102:118-9.
14. Jadresic D. Acute pancreatitis associated with dual vigabatrin and lamotrigine therapy (letter). Seizure 1994;3:319.