Intracranial self-stimulation

Neuromethods

Volumn 53, Issue , 2011, Pages 3-56

  Vlachou, Styliani ^a   Markou, Athina ^a  

^a NONE

Author keywords

9 Tetrahydrocannabinol; Amphetamine; Anhedonia; Benzodiazepines; Cocaine; Depression; Drug dependence; Drugs of abuse; Ethanol; Heroin; Intracranial self stimulation; Morphine; Motivation; Nicotine; Phencyclidine; Reward; Reward facilitating effect

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; AMPHETAMINE; CANNABINOID; CLOZAPINE; COCAINE; DEXAMPHETAMINE; DIAMORPHINE; DRONABINOL; FLUOXETINE; LEVONANTRADOL; MORPHINE; NICOTINE; PHENCYCLIDINE;

ALCOHOL ABUSE; ANHEDONIA; BRAIN DEPTH STIMULATION; COCAINE DEPENDENCE; DRUG ABUSE; HEROIN DEPENDENCE; INSTRUMENTAL CONDITIONING; LATERAL HYPOTHALAMUS; MEDIAL FOREBRAIN BUNDLE; MORPHINE ADDICTION; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; REVIEW; REWARD; SELF STIMULATION; STIMULUS RESPONSE; TOBACCO DEPENDENCE; VENTRAL TEGMENTUM; WITHDRAWAL SYNDROME;

ANIMALIA;

EID: 78649952898     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-934-5_1     Document Type: Review

References (299)

1. Rolls ET (1975) The neural basis of brain-stimulation reward. Prog Neurobiol 3:73-160
2. Hall RD, Bloom FE, Olds J (1977) Neuronal and neurochemical substrates of reinforcement. Neurosci Res Program Bull 15:131-314
3. Esposito RU, Motola A H D, Kornetsky C (1978) Cocaine: acute effects on reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle. Pharmacol Biochem Behav 8:437-439
4. Wise RA, Bozarth MA (1981) Brain substrates for reinforcement and drug self-administration. Prog Neuropsychopharmacol 5:467-474
5. Stellar JR, Stellar E (1990) The neurobiology of reward and motivation. Springer-Verlag, New York
6. Olds J, Milner P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 47:419-427
7. Yeomans JS (1990) "Temporal summation decay" in hypothalamic self-stimulation: threshold changes at long intrapair intervals due to axonal subnormal periods. Behav Neurosci 104:991-999
8. Markou A, Koob GF (1993) Intracranial selfstimulation thresholds as a measure of reward. In: Sahgal A (ed) Behavioral neuroscience: a practical approach, vol 2. IRL Press, Oxford, pp 93-115
9. Miliaressis E, Rompre PP, Durivage A (1982) Psychophysical method for mapping behavioral substrates using a moveable electrode. Brain Res Bull 8:693-701
10. Gallistel CR, Shizgal P, Yeomans JS (1981) A portrait of the substrate for self-stimulation. Psychol Rev 88:228-273
11. Markou A, Koob GF (1992) Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiol Behav 51:111-119
12. Frank RA, Markou A, Wiggins LL (1987) A systematic evaluation of the properties of selfstimulation train-duration response functions. Behav Neurosci 101:546-559
13. Markou A, Frank RA (1987) The effect of operant and electrode placement on self-stimulation train duration response functions. Physiol Behav 41:303-308
14. Wise RA (1996) Addictive drugs and brain stimulation reward. Annu Rev Neurosci 19:319-340
15. Edmonds DE, Gallistel CR (1974) Parametric analysis of brain stimulation reward in the rat: III. Effect of performance variables on the reward summation function. J Comp Physiol Psychol 87:876-883
16. Franklin KB (1978) Catecholamines and selfstimulation: reward and performances effects dissociated. Pharmacol Biochem Behav 9:813-820
17. Campbell KA, Evans G, Gallistel CR (1985) A microcomputer-based method for physiologically interpretable measurement of the rewarding efficacy of brain stimulation. Physiol Behav 35:395-403
18. Miliaressis E, Rompre PP, Laviolette P, Philippe L, Coulombe D (1986) The curveshift paradigm in self-stimulation. Physiol Behav 37:85-91
19. Kornetsky C, Esposito RU (1979) Euphorigenic drugs: effects on the reward pathways of the brain. Fed Proc 38:2473-2476
20. Kornetsky C, Esposito RU, McLean S, Jacobson JO (1979) Intracranial self-stimulation thresholds: a model for the hedonic effects of drugs of abuse. Arch Gen Psychiatry 36:289-292
21. Stein L, Ray OS (1960) Brain stimulation reward "thresholds" self-determined in rat. Psychopharmacologia 1:251-256
22. Schaefer GJ, Holtzman SG (1979) Free-operant and auto-titration brain self-stimulation procedures in the rat: a comparison of drug effects. Pharmacol Biochem Behav 10:127-135
23. Zarevics P, Setler PE (1981) Effects of GABAergic drugs on brain stimulation reward as assessed by a "threshold" method. Brain Res 215:201-209
24. Neill D, Gaar L, Clark A, Britt M (1982) "Ratefree" measures of self-stimulation and microinjections: evidence toward a new concept of dopamine and reward. In: Hoebel BG, Novin D (eds) The neural basis of feeding and reward. Haer Institute for Electrophysiological Research, Brunswick, ME, pp 289-298
25. Fouriezos G, Wise RA (1976) Pimozideinduced extinction of intracranial selfstimulation: response patterns rule out motor or performance deficits. Brain Res 103:377-380
26. Franklin KB, McCoy SN (1979) Pimozideinduced extinction in rats: stimulus control of responding rules out motor deficit. Pharmacol Biochem Behav 11:71-75
27. Fenton HM, Liebman JM (1982) Selfstimulation response decrement patterns differentiate clonidine, baclofen and do ppamine antagonists from drugs causing performance deficit. Pharmacol Biochem Behav 17:1207-1212
28. Gallistel CR, Boytim M, Gomita Y, Klebanoff L (1982) Does pimozide block the reinforcing effect of brain stimulation? Pharmacol Biochem Behav 17:769-781
29. Huston JP, Mills AW (1971) Threshold of reinforcing brain stimulation. Commun Behav Biol 5:331-340
30. Cassens GP, Mills AW (1973) Lithium and amphetamine: opposite effects on threshold of intracranial reinforcement. Psychopharmacologia 30:283-290
31. Herrnstein RJ (1974) Formal properties of the matching law. J Exp Anal Behav 21:159-164
32. Hamilton AL, Stellar JR, Hart EB (1985) Reward, performance, and the response strength method in self-stimulating rats: validation and neuroleptics. Physiol Behav 35:897-904
33. Liebman JM, Gerhardt S, Prowse J (1982) Differential effects of d-amphetamine, pipradrol and bupropion on shuttlebox selfstimulation. Pharmacol Biochem Behav 16:791-794
34. Liebman JM, Hall N, Prowse J (1982) Effects of various catecholamine receptor antagonists, muscle relaxation and physical hindrance on shuttlebox self-stimulation. Pharmacol Biochem Behav 16:785-790
35. Greenshaw AJ, Sanger DJ, Blackman DE (1985) Effects of d-amphetamine and of β-phenylethylamine on fixed interval responding maintained by self-regulated lateral hypothalamic stimulation in rats. Pharmacol Biochem Behav 23:519-523
36. Valenstein ES (1964) Problems of measurement and interpretation with reinforcing brain stimulation. Psychol Rev 71:415-437
37. Liebman JM (1983) Discriminating between reward and performance: a critical review of intracranial self-stimulation methodology. Neurosci Biobehav Rev 7:45-72
38. Coulombe D, Miliaressis E (1987) Fitting intracranial self-stimulation data with growth models. Behav Neurosci 101:209-214
39. Carlezon WA Jr, Chartoff EH (2007) Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc 2:2987-2995
40. Miliaressis E, Rompre PP (1987) Effects of concomitant motor reactions on the measurement of rewarding efficacy of brain stimulation. Behav Neurosci 101:827-831
41. Gallistel CR, Freyd G (1987) Quantitative determination of the effects of catecholaminergic agonists and antagonists on the rewarding efficacy of brain stimulation. Pharmacol Biochem Behav 26:731-741
42. Stellar JR, Rice MB (1989) Pharmacological basis of intracranial self-stimulation reward. In: Liebman JM, Cooper SJ (eds) The neuropharmacological basis of reward (series title: topics in experimental psychopharmacology). Clarendon Press, New York, pp 14-65
43. Fouriezos G, Wise RA (1984) Currentdistance relation for rewarding brain stimulation. Behav Brain Res 14:85-89
44. Fechner GT, Adler HE, Howes DH, Borin EG (1966) Elements of psychophysics, vol 1. Holt Rinehart & Winston, New York
45. Amitai N, Semenova S, Markou A (2009) Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure. Eur J Pharmacol 602:78-84
46. Kornetsky C (1985) Brain-stimulation reward: a model for the neuronal bases for drug-induced euphoria. NIDA Res Monogr 62:30-50
47. Jacques S (1979) Brain stimulation and reward: "pleasure centers" after twenty-five years. Neurosurgery 5:277-283
48. Kenny PJ, Markou A (2006) Nicotine selfadministration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity. Neuropsychopharmacology 31:1203-1211
49. Kenny PJ (2007) Brain reward systems and compulsive drug use. Trends Pharmacol Sci 28:135-141
50. Harrison AA, Gasparini F, Markou A (2002) Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. Psychopharmacology (Berl) 160:56-66
51. Kokkinidis L, Zacharko RM (1980) Intracranial self-stimulation in mice using a modified holeboard task: effects of d-amphetamine. Psychopharmacology (Berl) 68:169-171
52. Schaefer GJ, Michael RP (1986) Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal. Pharmacol Biochem Behav 25:1263-1269
53. Markou A, Koob GF (1991) Postcocaine anhedonia: an animal model of cocaine withdrawal. Neuropsychopharmacology 4:17-26
54. Schulteis G, Markou A, Cole M, Koob GF (1995) Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA 92:5880-5884
55. Epping-Jordan MP, Watkins SS, Koob GF, Markou A (1998) Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393:76-79
56. Spielewoy C, Markou A (2003) Withdrawal from chronic phencyclidine treatment induces long-lasting depression in brain reward function. Neuropsychopharmacology 28:1106-1116
57. Kenny PJ, Chen SA, Kitamura O, Markou A, Koob GF (2006) Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. J Neurosci 26:5894-5900
58. Olds J (1956) A preliminary mapping of electrical reinforcing effects in the rat brain. J Comp Physiol Psychol 49:281-285
59. Olds ME, Olds J (1963) Pharmacological patterns in subcortical reinforcement behavior. Int J Neuropharmacol 2:309-325
60. Millhouse OE (1969) A Golgi study of the desending medial forebrain bundle. Brain Res 15:341-363
61. Morgane PJ (1962) Dissociation of hypothalamic self-stimulation and primary "feeding system". Clin Res 10:185
62. Stein L (1964) Self-stimulation of the brain and the central stimulant action of amphetamine. Fed Proc 23:836-850
63. Stein L (1968) Chemistry of reward and punishment. In: Efron DH (ed) Psychopharmacology, a review of progress, 1957-1967. US Government Printing Office, Washington, DC, pp 105-123
64. Olds J, Allan WS, Briese E (1971) Differentiation of hypothalamic drive and reward centers. Am J Physiol 221:368-375
65. Phillips AG, Fibiger HC (1989) Neuroanatomical basis of intracranial self-stimulation reward: untangling the Gordian Knot. In: Liebman JM, Cooper SJ (eds) The neuropharmacological basis of reward (series title: Topics in experimental psychopharmacology). Oxford University Press, New York, pp 66-105
66. Miliaressis E, Thoa NB, Tizabi Y, Jacobowitz DM (1975) Catecholamine concentration of discrete brain areas following self-stimulation in the ventromedial tegmentum of the rat. Brain Res 100:192-197
67. Wurtz RH, Olds J (1963) Amygdaloid stimulation and operant reinforcement in the rat. J Comp Physiol Psychol 56:941-949
68. Miliaressis E, Bouchard A, Jacobowitz DM (1975) Strong positive reward in median raphe: specific inhibition by para-chlorophenylalanine. Brain Res 98:194-201
69. Tzschentke TM (2000) The medial prefrontal cortex as a part of the brain reward system. Amino Acids 19:211-219
70. Routtenberg A, Sloan M (1972) Selfstimulation in the frontal cortex of Rattus norvegicus. Behav Biol 7:567-572
71. Mora F, Phillips AG, Koolhaas JM, Rolls ET (1976) Prefrontal cortex and neostriatum selfstimulation in the rat: differential effects produced by apomorphine. Brain Res Bull 1:421-424
72. Corbett D, Laferriere A, Milner PM (1982) Elimination of medial prefrontal cortex selfstimulation following transection of efferents to the sulcal cortex in the rat. Physiol Behav 29:425-431
73. Corbett D, Laferriere A, Milner PM (1982) Plasticity of the medial prefrontal cortex: facilitated acquisition of intracranial self-stimulation by pretraining stimulation. Physiol Behav 28:531-534
74. Ursin R, Ursin H, Olds J (1966) Selfstimulation of hippocampus in rats. J Comp Physiol Psychol 61:353-359
75. Crow TJ, Spear PJ, Arbuthnott GW (1972) Intracranial self-stimulation with electrodes in the region of the locus coeruleus. Brain Res 36:275-287
76. van der Kooy D, Phillips AG (1977) Trigeminal substrates of intracranial self-stimulation in the brainstem. Science 196:447-449
77. Phillips AG (1970) Enhancement and inhibition of olfactory bulb self-stimulation by odours. Physiol Behav 5:1127-1131
78. Ball GG, Micco DJ Jr, Bernston GG (1974) Cerebellar stimulation in the rat: complex stimulation-bound oral behaviors and selfstimulation. Physiol Behav 13:123-127
79. Corbett D, Fox E, Milner PM (1982) Fiber pathways associated with cerebellar self-stimulation in the rat: a retrograde and anterograde tracing study. Behav Brain Res 6:167-184
80. Watson PJ (1978) Behavior maintained by electrical stimulation of the rat cerebellum. Physiol Behav 21:749-755
81. Olds J (1977) Drives and reinforcements: behavioral studies of hypothalamic function. Raven, New York
82. Berridge KC, Robinson TE (2003) Parsing reward. Trends Neurosci 26:507-513
83. Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481-1489
84. [erratum: 9(7):979]
85. Schultz W (2006) Behavioral theories and the neurophysiology of reward. Annu Rev Psychol 57:87-115
86. Kuczenski R (1977) Biphasic effects of amphetamine on striatal dopamine dynamics. Eur J Pharmacol 46:249-257
87. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278
88. 1B/1D antagonist. Psychopharmacology (Berl) 141:242-250
89. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL (2001) Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292:1175-1178
90. 3 antagonist Y-25130 blocks cocaine-induced lowering of ICSS reward thresholds in the rat. Pharmacol Biochem Behav 74:297-302
91. Di Chiara G, Bassareo V, Fenu S et al (2004) Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 47 (Suppl 1):227-241
92. Filip M, Frankowska M, Zaniewska M, Golda A, Przegalinski E (2005) The serotonergic system and its role in cocaine addiction. Pharmacol Rep 57:685-700
93. Esposito RU, Perry W, Kornetsky C (1980) Effects of d-amphetamine and naloxone on brain stimulation reward. Psychopharmacology (Berl) 69:187-191
94. Kornetsky C, Esposito RU (1981) Reward and detection thresholds for brain stimulation: dissociative effects of cocaine. Brain Res 209:496-500
95. Phillips AG, Fibiger HC (1973) Dopaminergic and noradrenergic substrates of positive reinforcement: differential effects of d-and l-amphetamine. Science 179:575-577
96. Franklin KB, Robertson A (1980) 5HT blockade and the stimulant effects of D-and L-amphetamine: no interaction in self-stimulation of prefrontal cortex, hypothalamus, or dorsal tegmentum. Unexpected lethality in hippocampal sites. Pharmacol Biochem Behav 13:365-370
97. Gallistel CR, Karras D (1984) Pimozide and amphetamine have opposing effects on the reward summation function. Pharmacol Biochem Behav 20:73-77
98. Leith NJ, Barrett RJ (1981) Self-stimulation and amphetamine: tolerance to d and l isomers and cross tolerance to cocaine and methylphenidate. Psychopharmacology (Berl) 74:23-28
99. Anderson JL, Leith NJ, Barrett RJ (1978) Tolerance to amphetamine's facilitation of self-stimulation responding: anatomical specificity. Brain Res 145:37-48
100. Leith NJ, Barrett RJ (1976) Amphetamine and the reward system: evidence for tolerance and post-drug depression. Psychopharmacologia 46:19-25
101. Liebman JM, Segal DS (1976) Lack of tolerance or sensitization to the effects of chronic d-amphetamine on substantia nigra self-stimulation. Behav Biol 16:211-220
102. Wauquier A, Niemergeers CJ (1974) Intracranial self-stimulation in rats as a function of various stimulus parameters: V. Influence of cocaine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia 38:201-210
103. Phillips AG, Broekkamp CL, Fibiger HC (1983) Strategies for studying the neurochemical substrates of drug reinforcement in rodents. Prog Neuropsychopharmacol Biol Psychiatry 7:585-590
104. Frank RA, Pommering T, Nitz D (1988) The interactive effects of cocaine and imipramine on self-stimulation train-duration thresholds. Pharmacol Biochem Behav 30:1-4 (Pubitemid 19268783)
105. van Wolfswinkel L, Seifert WF, van Ree JM (1988) Catecholamines and endogenous opioids in ventral tegmental self-stimulation reward. Pharmacol Biochem Behav 30:589-595
106. Kokkinidis L, McCarter BD (1990) Postcocaine depression and sensitization of brainstimulation reward: analysis of reinforcement and performance effects. Pharmacol Biochem Behav 36:463-471
107. Moody CA, Frank RA (1990) Cocaine facilitates prefrontal cortex self-stimulation. Pharmacol Biochem Behav 35:743-746
108. Corbett D (1991) Cocaine enhances the reward value of medial prefrontal cortex selfstimulation. NeuroReport 2:805-808
109. Williams HP, Manderscheid PZ, Schwartz M, Frank RA (1991) Cocaine's effects on rate of intracranial self-stimulation. Pharmacol Biochem Behav 40:273-277
110. Markou A, Koob GF (1992) Bromocriptine reverses the elevation in intracranial selfstimulation thresholds observed in a rat model of cocaine withdrawal. Neuropsychopharmacology 7:213-224
111. Kling-Petersen T, Ljung E, Svensson K (1994) The preferential dopamine autoreceptor antagonist (+)-UH232 antagonizes the positive reinforcing effects of cocaine and d-amphetamine in the ICSS paradigm. Pharmacol Biochem Behav 49:345-351
112. Maldonado-Irizarry CS, Stellar JR, Kelley AE (1994) Effects of cocaine and GBR-12909 on brain stimulation reward. Pharmacol Biochem Behav 48:915-920
113. Panagis G, Spyraki C (1996) Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation. Psychopharmacology (Berl) 123:280-288
114. Kita K, Shiratani T, Takenouchi K, Fukuzako H, Takigawa M (1999) Effects of D1 and D2 dopamine receptor antagonists on cocaineinduced self-stimulation and locomotor activity in rats. Eur Neuropsychopharmacol 9:1-7
115. 7 nicotinic receptor antagonist, on nicotine-and cocaine-induced potentiation of brain stimulation reward. Psychopharmacology (Berl) 149:388-396
116. Gilliss B, Malanga CJ, Pieper JO, Carlezon WA Jr (2002) Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice. Psychopharmacology (Berl) 163:238-248
117. Kenny PJ, Koob GF, Markou A (2003) Conditioned facilitation of brain reward function after repeated cocaine administration. Behav Neurosci 117:1103-1107
118. Kenny PJ, Paterson NE, Boutrel B et al (2003) Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann NY Acad Sci 1003:415-418
119. Hayes RJ, Gardner EL (2004) The basolateral complex of the amygdala mediates the modulation of intracranial self-stimulation threshold by drug-associated cues. Eur J Neurosci 20:273-280
120. Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A (2005) Metabotropic glutamate 5 receptor blockade may attenuate cocaine selfadministration by decreasing brain reward function in rats. Psychopharmacology (Berl) 179:247-254
121. Mague SD, Andersen SL, Carlezon WA Jr (2005) Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biol Psychiatry 57:120-125
122. B receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat. Neuropsychopharmacology 30:2065-2072
123. Hernandez G, Haines E, Shizgal P (2008) Potentiation of intracranial self-stimulation during prolonged subcutaneous infusion of cocaine. J Neurosci Methods 175:79-87
124. Tomasiewicz HC, Todtenkopf MS, Chartoff EH, Cohen BM, Carlezon WA Jr (2008) The kappa-opioid agonist U69, 593 blocks cocaine-induced enhancement of brain stimulation reward. Biol Psychiatry 64:982-988
125. 1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine. Int J Neuropsychopharmacol 11:905-923
126. Crow TJ (1970) Enhancement of cocaine intra-cranial self-stimulation in the rat. Life Sci 9:375-381
127. Frank RA, Manderscheid PZ, Panicker S, Williams HP, Kokoris D (1992) Cocaine euphoria, dysphoria, and tolerance assessed using drug-induced changes in brainstimulation reward. Pharmacol Biochem Behav 42:771-779
128. Frank RA, Zubrycki E (1989) Chronic imipramine does not block cocaine-induced increases in brain stimulation reward. Pharmacol Biochem Behav 33:725-727
129. Frank RA, Martz S, Pommering T (1988) The effect of chronic cocaine on self-stimulation train-duration thresholds. Pharmacol Biochem Behav 29:755-758
130. Kenny PJ, Polis I, Koob GF, Markou A (2003) Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. Eur J Neurosci 17:191-195
131. Stratmann JA, Craft RM (1997) Intracranial self-stimulation in female and male rats: no sex differences using a rate-independent procedure. Drug Alcohol Depend 46:31-40
132. Markou A, Hauger RL, Koob GF (1992) Desmethylimipramine attenuates cocaine withdrawal in rats. Psychopharmacology (Berl) 109:305-314
133. Hammer RP Jr, Egilmez Y, Emmett-Oglesby MW (1997) Neural mechanisms of tolerance to the effects of cocaine. Behav Brain Res 84:225-239
134. Goussakov I, Chartoff EH, Tsvetkov E et al (2006) LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci 23:239-250
135. Baldo BA, Koob GF, Markou A (1999) Role of adenosine A2 receptors in brain stimulation reward under baseline conditions and during cocaine withdrawal in rats. J Neurosci 19:11017-11026
136. Baldo BA, Markou A, Koob GF (1999) Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology (Berl) 141:135-144
137. Weiss F, Markou A, Lorang MT, Koob GF (1992) Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain Res 593:314-318
138. Robertson A, Laferriere A, Franklin KB (1981) Amphetamine and increases in current intensity modulate reward in the hypothalamus and substantia nigra but not in the prefrontal cortex. Physiol Behav 26:809-813
139. Schaefer GJ, Michael RP (1988) An analysis of the effects of amphetamine on brain selfstimulation behavior. Behav Brain Res 29:93-101
140. Elmer GI, Pieper JO, Levy J et al (2005) Brain stimulation and morphine reward deficits in dopamine D2 receptor-deficient mice. Psychopharmacology (Berl) 182:33-44
141. Hao J, Cabeza de Vaca S, Pan Y, Carr KD (2006) Effects of central leptin infusion on the reward-potentiating effect of D-amphetamine. Brain Res 1087:123-133
142. 2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats. Psychopharmacology (Berl) 203(3):579-588
143. Kamens HM, Burkhart-Kasch S, McKinnon CS, Li N, Reed C, Phillips TJ (2005) Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine. Genes Brain Behav 4:110-125
144. Lin D, Bruijnzeel AW, Schmidt P, Markou A (2002) Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine. Neuroscience 114:925-933
145. Sweet KL, Neill DB (1999) Amphetamine injections into the nucleus accumbens enhance the reward of stimulation of the subiculum. Ann NY Acad Sci 877:828-830
146. 2A antagonism of amphetamine-induced facilitation of brain stimulation reward. Pharmacol Biochem Behav 52:799-804
147. Olds ME, Yuwiler A (1992) Effects of acute and chronic fenfluramine on self-stimulation and its facilitation by amphetamine. Eur J Pharmacol 216:363-372
148. Schaefer GJ, West CH, Michael RP (1987) Self-training for brain stimulation in the medial forebrain bundle of rats: a comparison of saline with amphetamine. Behav Brain Res 24:215-220
149. Hand TH, Franklin KB (1983) The influence of amphetamine on preference for lateral hypothalamic versus prefrontal cortex or ventral tegmental area self-stimulation. Pharmacol Biochem Behav 18:695-699
150. Zacharko RM, Kokkinidis L (1982) Preference for fixed vs self-selected durations of brain stimulation in rats administered D-amphetamine sulphate. Life Sci 30:1029-1034
151. Franklin KB, Robertson A (1982) Effects and interactions of naloxone and amphetamine on self-stimulation of the prefrontal cortex and dorsal tegmentum. Pharmacol Biochem Behav 16:433-436
152. Kokkinidis L, Zacharko RM (1980) Response sensitization and depression following longterm amphetamine treatment in a self-stimulation paradigm. Psychopharmacology (Berl) 68:73-76
153. Robertson A, Mogenson GJ (1979) Facilitation of self-stimulation of the prefrontal cortex in rats following chronic administration of spiroperidol or amphetamine. Psychopharmacology (Berl) 65:149-154
154. Zacharko RM, Wishart TB (1979) Facilitation of self-stimulation with high doses of amphetamine in the rat. Psychopharmacology (Berl) 64:247-248
155. Koob GF, Winger GD, Meyerhoff JL, Annau Z (1977) Effects of D-amphetamine on concurrent self-stimulation of forebrain and brain stem loci. Brain Res 137:109-126
156. Liebman J, Segal DS (1977) Differential effects of morphine and D-amphetamine on self-stimulation from closely adjacent regions in rat midbrain. Brain Res 136:103-117
157. Howard JL, Pollard GT, Rohrbach KW, Harto NE (1976) Effect of β-phenylethylamine and d-amphetamine on electrical self-stimulation of brain. Pharmacol Biochem Behav 5:661-664
158. Cazala P (1976) Effects of d-and l-amphetamine on dorsal and ventral hypothalamic self-stimulation in three inbred strains of mice. Pharmacol Biochem Behav 5:505-510
159. Ellman SJ, Ackermann RF, Bodnar RJ, Jackler F, Steiner SS (1976) D-and L-amphetamine differentially mediates self-stimulation in rat dorsal midbrain area. Physiol Behav 16:1-7
160. Olds ME (1972) Comparative effects of amphetamine, scopolamine and clordiazepoxide on self-stimulation behavior. Rev Can Biol 31 (Suppl): 25-47
161. Leith NJ, Barrett RJ (1980) Effects of chronic amphetamine or reserpine on self-stimulation responding: animal model of depression? Psychopharmacology (Berl) 72:9-15
162. Predy PA, Kokkinidis L (1981) Postamphetamine depression of self-stimulation behavior in rats: prophylactic effects of lithium. Neurosci Lett 23:343-347
163. Borowski TB, Kokkinidis L (1992) Longterm influence of d-amphetamine on mesolimbic brain-stimulation reward: comparison to chronic haloperidol and naloxone effects. Pharmacol Biochem Behav 43:1-15
164. Paterson NE, Myers C, Markou A (2000) Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats. Psychopharmacology (Berl) 152:440-446
165. Harrison AA, Liem YT, Markou A (2001) Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology 25:55-71
166. Barr AM, Markou A, Phillips AG (2002) A "crash" course on psychostimulant withdrawal as a model of depression. Trends Pharmacol Sci 23:475-482
167. Cryan JF, Hoyer D, Markou A (2003) Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents. Biol Psychiatry 54:49-58
168. 1A receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats. Psychopharmacology (Berl) 178:133-142
169. Wise RA, Munn E (1995) Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds. Psychopharmacology (Berl) 117:130-136
170. Kokkinidis L, Zacharko RM, Anisman H (1986) Amphetamine withdrawal: a behavioral evaluation. Life Sci 38:1617-1623
171. Cassens G, Actor C, Kling M, Schildkraut JJ (1981) Amphetamine withdrawal: effects on threshold of intracranial reinforcement. Psychopharmacology (Berl) 73:318-322
172. Simpson DM, Annau Z (1977) Behavioral withdrawal following several psychoactive drugs. Pharmacol Biochem Behav 7:59-64
173. Barr AM, Zis AP, Phillips AG (2002) Repeated electroconvulsive shock attenuates the depressive-like effects of d-amphetamine withdrawal on brain reward function in rats. Psychopharmacology (Berl) 159:196-202
174. Lin D, Koob GF, Markou A (1999) Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat: interactions between the two drugs. Psychopharmacology (Berl) 145:283-294
175. Takigawa M, Maeda H, Ueyama K, Tominaga H, Matsumoto K (1993) A dual approach to self-stimulation and locomotor trace affected by chronic methamphetamine treatment for an animal model of schizophrenia. Can J Physiol Pharmacol 71:321-325
176. Sagara H, Kitamura Y, Sendo T, Araki H, Gomita Y (2008) Motivational effects of methamphetamine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. Biol Pharm Bull 31:541-545 (Pubitemid 351500469)
177. Stolerman IP, Jarvis MJ (1995) The scientific case that nicotine is addictive. Psychopharmacology (Berl) 117:2-10, discussion 4-20
178. Clarke P B S, Kumar R (1984) Effects of nicotine and d-amphetamine on intracranial selfstimulation in a shuttle box test in rats. Psychopharmacology (Berl) 84:109-114
179. Schaefer GJ, Michael RP (1986) Task-specific effects of nicotine in rats: intracranial selfstimulation and locomotor activity. Neuropharmacology 25:125-131
180. Arregui-Aguirre A, Claro-Izaguirre F, Goni-Garrido MJ, Zarate-Oleaga JA, Morgado-Bernal I (1987) Effects of acute nicotine and ethanol on medial prefrontal cortex selfstimulation in rats. Pharmacol Biochem Behav 27:15-20
181. Bespalov A, Lebedev A, Panchenko G, Zvartau E (1999) Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats. Eur Neuropsychopharmacol 9:377-383
182. Huston-Lyons D, Sarkar M, Kornetsky C (1993) Nicotine and brain-stimulation reward: interactions with morphine, amphetamine and pimozide. Pharmacol Biochem Behav 46:453-457
183. Kenny PJ, Chartoff E, Roberto M, Carlezon WA Jr, Markou A (2009) NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine selfadministration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology 34:266-281
184. Paterson NE, Balfour DJ, Markou A (2008) Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats. Nicotine Tob Res 10:995-1008
185. B receptors decreased nicotine self-administration and counteracted nicotineinduced enhancement of brain reward function in rats. J Pharmacol Exp Ther 326:306-314
186. Sagara H, Kitamura Y, Esumi S, Sendo T, Araki H, Gomita Y (2008) Motivational effects of nicotine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior. Acta Med Okayama
187. Herberg LJ, Montgomery AM, Rose IC (1993) Tolerance and sensitization to stimulant and depressant effects of nicotine in intracranial self-stimulation in the rat. Behav Pharmacol 4:419-427
188. Di Chiara G (2000) Role of dopamine in the behavioural actions of nicotine related to addiction. Eur J Pharmacol 393:295-314
189. Schaefer GJ, Michael RP (1992) Interactions between alcohol and nicotine on intracranial self-stimulation and locomotor activity in rats. Drug Alcohol Depend 30:37-47
190. Hollander JA, Lu Q, Cameron MD, Kamenecka TM, Kenny PJ (2008) Insular hypocretin transmission regulates nicotine reward. Proc Natl Acad Sci USA 105:19480-19485
191. Malin DH, Lake JR, Newlin-Maultsby P et al (1992) Rodent model of nicotine abstinence syndrome. Pharmacol Biochem Behav 43:779-784
192. Malin DH, Lake JR, Carter VA, Cunningham JS, Wilson OB (1993) Naloxone precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 112:339-342
193. Malin DH, Lake JR, Carter VA et al (1994) The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat. Psychopharmacology (Berl) 115:180-184
194. Hildebrand BE, Panagis G, Svensson TH, Nomikos GG (1999) Behavioral and biochemical manifestations of mecamylamineprecipitated nicotine withdrawal in the rat: role of nicotinic receptors in the ventral tegmental area. Neuropsychopharmacology 21:560-574
195. Markou A, Paterson NE (2001) The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine Tob Res 3:361-373
196. Bruijnzeel AW, Markou A (2004) Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats. Neuropharmacology 47:572-579
197. Johnson PM, Hollander JA, Kenny PJ (2008) Decreased brain reward function during nicotine withdrawal in C57BL6 mice: evidence from intracranial self-stimulation (ICSS) studies. Pharmacol Biochem Behav 90:409-415
198. Jonkman S, Risbrough VB, Geyer MA, Markou A (2008) Spontaneous nicotine withdrawal potentiates the effects of stress in rats. Neuropsychopharmacology 33:2131-2138
199. Stoker AK, Semenova S, Markou A (2008) Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6 J and BALB/cByJ mice. Neuropharmacology 54:1223-1232
200. Watkins SS, Stinus L, Koob GF, Markou A (2000) Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects. J Pharmacol Exp Ther 292:1053-1064
201. Kenny PJ, Markou A (2001) Neurobiology of the nicotine withdrawal syndrome. Pharmacol Biochem Behav 70:531-549
202. Shiffman SM, Jarvik ME (1976) Smoking withdrawal symptoms in two weeks of abstinence. Psychopharmacology (Berl) 50:35-39
203. LeSage MG, Burroughs D, Pentel PR (2006) Effects of nicotine withdrawal on performance under a progressive-ratio schedule of sucrose pellet delivery in rats. Pharmacol Biochem Behav 83:585-591
204. Jonkman S, Markou A (2006) Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats. Neurosci Lett 400:140-145
205. O'Dell LE, Bruijnzeel AW, Smith RT et al (2006) Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology (Berl) 186:612-619
206. Liechti ME, Markou A (2007) Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats. Biochem Pharmacol 74:1299-1307
207. Liechti ME, Markou A (2007) Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. Eur J Pharmacol 554:164-174
208. Paterson NE, Semenova S, Markou A (2008) The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat. Psychopharmacology (Berl) 198:351-362
209. 26]-NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats. Neuropeptides 42:215-227
210. Kenny PJ, Markou A (2005) Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems. J Neurosci 25:6208-6212
211. Panagis G, Kastellakis A, Spyraki C (1998) Involvement of the ventral tegmental area opiate receptors in self-stimulation elicited from the ventral pallidum. Psychopharmacology (Berl) 139:222-229
212. Paterson NE, Balfour DJ, Markou A (2007) Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. Eur J Neurosci 25:3099-3108
213. Fowler CD, Arends MA, Kenny PJ (2008) Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behav Pharmacol 19:461-484
214. Ivanova S, Greenshaw AJ (1997) Nicotineinduced decreases in VTA electrical self-stimulation thresholds: blockade by haloperidol and mecamylamine but not scopolamine or ondansetron. Psychopharmacology (Berl) 134:187-192
215. Hildebrand BE, Nomikos GG, Hertel P, Schilstrom B, Svensson TH (1998) Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain Res 779:214-225
216. Hildebrand BE, Svensson TH (2000) Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats. J Neural Transm 107:861-872
217. Cryan JF, Bruijnzeel AW, Skjei KL, Markou A (2003) Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat. Psychopharmacology (Berl) 168:347-358
218. Kenny PJ, Gasparini F, Markou A (2003) Group II metabotropic and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. J Pharmacol Exp Ther 306:1068-1076
219. Bruijnzeel AW, Zislis G, Wilson C, Gold MS (2007) Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats. Neuropsychopharmacology 32:955-963
220. Marcinkiewcz CA, Prado MM, Isaac SK, Marshall A, Rylkova D, Bruijnzeel AW (2009) Corticotropin-releasing factor within the central nucleus of the amygdala and the nucleus accumbens shell mediates the negative affective state of nicotine withdrawal in rats. Neuropsychopharmacology 34(7):1743-1752
221. Balfour DJ (2002) Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence. Curr Drug Targets CNS Neurol Disord 1:413-421
222. Wauquier A, Niemegeers CJ (1976) Intracranial self-stimulation in rats as a function of various stimulus parameters: VI. Influence of fentanyl, piritramide, and morphine on medial forebrain bundle stimulation with monopolar electrodes. Psychopharmacologia 46:179-183
223. Seeger TF, Nazzaro JM, Gardner EL (1980) Selective inhibition of mesolimbic behavioral supersensitivity by naloxone. Eur J Pharmacol 65:435-438
224. Hand TH, Franklin KB (1985) 6-OHDA lesions of the ventral tegmental area block morphine-induced but not amphetamineinduced facilitation of self-stimulation. Brain Res 328:233-241
225. van Wolfswinkel L, van Ree JM (1985) Effects of morphine and naloxone on thresholds of ventral tegmental electrical self-stimulation. Naunyn Schmiedebergs Arch Pharmacol 330:84-92
226. Hand TH, Franklin KB (1986) Associative factors in the effects of morphine on selfstimulation. Psychopharmacology (Berl) 88:472-479
227. Esposito R, Kornetsky C (1977) Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration. Science 195:189-191
228. Esposito RU, McLean S, Kornetsky C (1979) Effects of morphine on intracranial self-stimulation to various brain stem loci. Brain Res 168:425-429
229. Bozarth MA, Gerber GJ, Wise RA (1980) Intracranial self-stimulation as a technique to study the reward properties of drugs of abuse. Pharmacol Biochem Behav 13 (Suppl 1):245-247
230. Nazzaro JM, Seeger TF, Gardner EL (1981) Morphine differentially affects ventral tegmental and substantia nigra brain reward thresholds. Pharmacol Biochem Behav 14:325-331
231. Hubner CB, Kornetsky C (1992) Heroin, 6-acetylmorphine and morphine effects on threshold for rewarding and aversive brain stimulation. J Pharmacol Exp Ther 260:562-567
232. Holtzman SG (1976) Comparison of the effects of morphine, pentazocine, cyclazocine and amphetamine on intracranial selfstimulation in the rat. Psychopharmacologia 46:223-227
233. Schaefer GJ, Holtzman SG (1977) Dose-and time-dependent effects of narcotic analgesics on intracranial self-stimulation in the rat. Psychopharmacology (Berl) 53:227-234
234. Jackler F, Steiner SS, Bodnar RJ, Ackermann RF, Nelson WT, Ellman SJ (1979) Morphine and intracranial self-stimulation in the hypothalamus and dorsal brainstem: differential effects of dose, time and site. Int J Neurosci 9:21-35
235. Weibel SL, Wolf HH (1979) Opiate modification of intracranial self-stimulation in the rat. Pharmacol Biochem Behav 10:71-78
236. Bermudez-Rattoni F, Cruz-Morales S, Reid LD (1983) Addictive agents and intracranial stimulation (ICS): novel antagonists and agonists of morphine and pressing for ICS. Pharmacol Biochem Behav 18:777-784
237. Weeks JR (1962) Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats. Science 138:143-144
238. Thompson T, Schuster CR (1964) Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia 5:87-94
239. Schaefer GJ, Michael RP (1990) Interactions of naloxone with morphine, amphetamine and phencyclidine on fixed interval responding for intracranial self-stimulation in rats. Psychopharmacology (Berl) 102:263-268
240. Koob GF, Spector NH, Meyerhoff JL (1975) Effects of heroin on lever pressing for intracranial self-stimulation, food and water in the rat. Psychopharmacologia 42:231-234
241. Gerber GJ, Bozarth MA, Spindler JE, Wise RA (1985) Concurrent heroin self-administration and intracranial self-stimulation in rats. Pharmacol Biochem Behav 23:837-842
242. van der Kooy D, Schiff BB, Steele D (1978) Response-dependent effects of morphine on reinforcing lateral hypothalamic self-stimulation. Psychopharmacology (Berl) 58:63-67
243. Bespalov A, Dumpis M, Piotrovsky L, Zvartau E (1994) Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine. Eur J Pharmacol 264:233-239
244. Easterling KW, Holtzman SG (1997) Intracranial self-stimulation in rats: sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists. J Pharmacol Exp Ther 281:188-199
245. Easterling KW, Plovnick RM, Holtzman SG (2000) Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation. Psychopharmacology (Berl) 148:263-271
246. Easterling KW, Holtzman SG (2004) In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation. Psychopharmacology (Berl) 175:287-295
247. Schulteis G, Markou A, Gold LH, Stinus L, Koob GF (1994) Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis. J Pharmacol Exp Ther 271:1391-1398
248. Meyer DR, Sparber SB (1977) Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine. Life Sci 21:1087-1093
249. Young AM (1986) Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone. Psychopharmacology (Berl) 88:201-208
250. Adams JU, Holtzman SG (1990) Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats. J Pharmacol Exp Ther 253:483-489
251. Bruijnzeel AW, Marcinkiewcz C, Isaac S, Booth MM, Dennis DM, Gold MS (2007) The effects of buprenorphine on fentanyl withdrawal in rats. Psychopharmacology (Berl) 191:931-941
252. 9-tetrahydrocannabinol. Psychopharmacology (Berl) 96:142-144
253. 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. Life Sci 58: PL365-PL372 (Pubitemid 126334928)
254. Gardner EL, Vorel SR (1998) Cannabinoid transmission and reward-related events. Neurobiol Dis 5:502-533
255. Gardner EL, Vorel SR (1989) Facilitation of brain stimulation reward by D9-tetrahydrocannabinol is mediated by an endogenous opioid mechanism. Adv Biosci 75:4
256. Stark P, Dews PB (1980) Cannabinoids: II. Cardiovascular effects. J Pharmacol Exp Ther 214:131-138
257. Kucharski LT, Williams JE, Kornetsky C (1983) The effects of levonantradol on rewarding brain stimulation thresholds in the rat. Pharmacol Biochem Behav 19:149-151
258. 9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodents. Behav Pharmacol 18:311-319
259. Stark P, Dews PB (1980) Cannabinoids: I Behavioral effects. J Pharmacol Exp Ther 214:124-130
260. Arnold JC, Hunt GE, McGregor IS (2001) Effects of the cannabinoid receptor agonist CP 55, 940 and the cannabinoid receptor antagonist SR 141716 on intracranial selfstimulation in Lewis rats. Life Sci 70:97-108
261. 8-THC analog, AMG-3. Behav Pharmacol 16:499-510
262. 1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat. Psychopharmacology (Berl) 179:498-508
263. 1 cannabinoid receptor stimulation. Behav Brain Res 141:215-222
264. Vlachou S, Nomikos GG, Panagis G (2006) Effects of endocannabinoid neurotransmission modulators on brain stimulation reward. Psychopharmacology (Berl) 188:293-305
265. 1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats. Psychopharmacology (Berl) 157:254-259
266. Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A (2007) Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 370:1706-1713
267. Green B, Kavanagh D, Young R (2003) Being stoned: a review of self-reported cannabis effects. Drug Alcohol Rev 22:453-460
268. Gregg JM, Small EW, Moore R, Raft D, Toomey TC (1976) Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery. J Oral Surg 34:301-313
269. McCabe M, Smith FP, Macdonald JS, Woolley PV, Goldberg D, Schein PS (1988) Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy. Invest New Drugs 6:243-246
270. De Witte P (1982) Brain stimulation as the reinforcer in alcohol-saline discrimination. Pharmacol Biochem Behav 17:1093-1096 (Pubitemid 13222250)
271. De Witte P, Bada MF (1983) Self-stimulation and alcohol administered orally or intraperitoneally. Exp Neurol 82:675-682
272. Moolten M, Kornetsky C (1990) Oral selfadministration of ethanol and not experimenter-administered ethanol facilitates rewarding electrical brain stimulation. Alcohol 7:221-225
273. Carlson RH, Lydic R (1976) The effects of ethanol upon threshold and response rate for self-stimulation. Psychopharmacology (Berl) 50:61-64
274. Routtenberg A (1981) Drug of abuse and the endogenous reinforcement system: the resistance of intracranial self-stimulation behavior to the inebriating effects of ethanol. Ann NY Acad Sci 362:60-66
275. Schaefer GJ, Michael RP (1987) Ethanol and current thresholds for brain self-stimulation in the lateral hypothalamus of the rat. Alcohol 4:209-213
276. Schaefer GJ, Michael RP (1991) Effects of an alcohol diet on locomotor activity and the acquisition of brain self-stimulation in rats. Alcohol 8:71-75
277. Chester JA, Rausch EJ, June HL, Froehlich JC (2006) Decreased reward during acute alcohol withdrawal in rats selectively bred for low alcohol drinking. Alcohol 38:165-172
278. Olds J, Travis RP (1960) Effects of chlorpromazine, meprobamate, pentobarbital and morphine on self-stimulation. J Pharmacol Exp Ther 128:397-404
279. Seeger TF, Carlson KR, Nazzaro JM (1981) Pentobarbital induces a naloxone-reversible decrease in mesolimbic self-stimulation threshold. Pharmacol Biochem Behav 15:583-586
280. Caudarella M, Campbell KA, Milgram NW (1982) Differential effects of diazepam (valium) on brain stimulation reward sites. Pharmacol Biochem Behav 16:17-21
281. Herberg LJ, Williams SF (1983) Anti-conflict and depressant effects by GABA agonists and antagonists, benzodiazepines and non-gabergic anticonvulsants on self-stimulation and locomotor activity. Pharmacol Biochem Behav 19:625-633
282. Sagara H, Kitamura Y, Sendo T, Araki H, Gomita Y (2008) Effect of diazepam on the runway method using priming stimulation of intracranial self stimulation behavior. J Pharmacol Sci 107:355-360 (Pubitemid 352030323)
283. Domino EF, Olds ME (1972) Effects of d-amphetamine, scopolamine, chlordiazepoxide and diphenylhydantoin on self-stimulation behavior and brain acetylcholine. Psychopharmacologia 23:1-16
284. Olds ME (1976) Effectiveness of morphine and ineffectiveness of diazepam and phenobarbital on the motivational properties of hypothalamic self-stimulation behaviour. Neuropharmacology 15:117-131
285. Gomita Y, Ichimaru Y, Moriyama M, Araki H, Futagami K (2003) Effects of anxiolytic drugs on rewarding and aversive behaviors induced by intracranial stimulation. Acta Med Okayama 57:95-108
286. Liebman JM (1985) Anxiety, anxiolytics and brain stimulation reinforcement. Neurosci Biobehav Rev 9:75-86
287. Gomita Y, Ueki S (1981) "Conflict" situation based on intracranial self-stimulation behavior and the effect of benzodiazepines. Pharmacol Biochem Behav 14:219-222
288. Moriyama M, Ichimaru Y, Gomita Y (1984) Behavioral suppression using intracranial reward and punishment: effects of benzodiazepines. Pharmacol Biochem Behav 21:773-778
289. Ichimaru Y, Moriyama M, Gomita Y (1985) Auto-titration technique using intracranial self-stimulation and effects of antianxiety drugs. Jpn J Pharmacol 39:331-338
290. Carlezon WA Jr, Wise RA (1993) Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration. Psychopharmacology (Berl) 111:402-408
291. Carlezon WA Jr, Wise RA (1996) Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward. Psychopharmacology (Berl) 128:413-420
292. Carlezon WA Jr, Wise RA (1996) Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci 16:3112-3122
293. Nichols DE (1986) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens: identification of a new therapeutic class: entactogens. J Psychoactive Drugs 18:305-313
294. Oberlender R, Nichols DE (1988) Drug discrimination studies with MDMA and amphetamine. Psychopharmacology (Berl) 95:71-76
295. Baylen CA, Rosenberg H (2006) A review of the acute subjective effects of MDMA/ecstasy. Addiction 101:933-947
296. Hubner CB, Bird M, Rassnick S, Kornetsky C (1988) The threshold lowering effects of MDMA (ecstasy) on brain-stimulation reward. Psychopharmacology (Berl) 95:49-51
297. Reid LD, Hubbell CL, Tsai J, Fishkin MD, Amendola CA (1996) Naltrindole, a δ-opioid antagonist, blocks MDMA's ability to enhance pressing for rewarding brain stimulation. Pharmacol Biochem Behav 53:477-480
298. Bossert JM, Franklin KB (2003) Reinforcing versus anticonvulsant drugs: effects on intracranial self-stimulation rate-frequency M50 indices. Behav Brain Res 144:243-247
299. Semenova S, Markou A (2003) Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine. Biol Psychiatry 54:1249-1264