-
3
-
-
0842333135
-
In vitro and in vivo characterization of doxorubicin and vincristine coencapsulated within liposomes through use of transition metal ion complexation and pH gradient loading
-
Abraham SA, McKenzie C, Masin D, et al. In vitro and in vivo characterization of doxorubicin and vincristine coencapsulated within liposomes through use of transition metal ion complexation and pH gradient loading. Clin Cancer Res 2004;10:728-38
-
(2004)
Clin. Cancer. Res.
, vol.10
, pp. 728-738
-
-
Abraham, S.A.1
McKenzie, C.2
Masin, D.3
-
4
-
-
84995517054
-
Fixed drug ratio liposome formulations of combination cancer therapeutics
-
Gregoriadis G, editor Interactions of liposomes with biological milieu. 3rd edition. Volume III. Informa Healthcare, Inc., New York, USA;
-
Harasym TO, Tardi PG, Johnstone SA, et al. Fixed drug ratio liposome formulations of combination cancer therapeutics. In: Gregoriadis G, editor, Liposome technology. Interactions of liposomes with biological milieu. 3rd edition. Volume III. Informa Healthcare, Inc., New York, USA; 2007b. p. 25-46
-
(2007)
Liposome technology
, pp. 25-46
-
-
Harasym, T.O.1
Tardi, P.G.2
Johnstone, S.A.3
-
5
-
-
33748326024
-
Ratiometric dosing of anticancer drug combinations: Controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice
-
Mayer LD, Harasym TO, Tardi PG, et al. Ratiometric dosing of anticancer drug combinations: controlling drug ratios after systemic administration regulates therapeutic activity in tumor-bearing mice. Mol Cancer Ther 2006;5:1854-63
-
(2006)
Mol. Cancer. Ther.
, vol.5
, pp. 1854-1863
-
-
Mayer, L.D.1
Harasym, T.O.2
Tardi, P.G.3
-
6
-
-
34548759797
-
Optimizing combination chemotherapy by controlling drug ratios
-
Mayer LD, Janoff AS. Optimizing combination chemotherapy by controlling drug ratios. Mol Interv 2007;7:216-23
-
(2007)
Mol. Interv.
, vol.7
, pp. 216-223
-
-
Mayer, L.D.1
Janoff, A.S.2
-
7
-
-
0002658306
-
The median-effect principle and the combination index for quantitation of synergism and antagonism
-
Chou TC, Rideout DC, editors, Academic Press, New York
-
Chou TC. The median-effect principle and the combination index for quantitation of synergism and antagonism. In: Chou TC, Rideout DC, editors, Synergism and antagonism in chemotherapy. Academic Press, New York; 1991. p. 61-102
-
(1991)
Synergism and Antagonism in Chemotherapy
, pp. 61-102
-
-
Chou, T.C.1
-
8
-
-
0021118703
-
Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
-
Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55
-
(1984)
Adv. Enzyme Regul.
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
9
-
-
33748794547
-
Theoretical basis experimental design and computerized simulation of synergsim and antagonism in drug combination studies
-
Chou TC. Theoretical basis, experimental design, and computerized simulation of synergsim and antagonism in drug combination studies. Pharmacol Rev 2006;58:621-81
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 621-681
-
-
Chou, T.C.1
-
10
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 1995;47:331-85
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
11
-
-
0015900070
-
Role of cholesterol in membranes effects on phospholipid-protein interactions membrane permeability and enzymatic activity
-
Papahadjopoulos D, Cowden M, Kimelberg H. Role of cholesterol in membranes. Effects on phospholipid-protein interactions, membrane permeability and enzymatic activity. Biochim Biophys Acta 1973;330:8-26
-
(1973)
Biochim. Biophys. Acta.
, vol.330
, pp. 8-26
-
-
Papahadjopoulos, D.1
Cowden, M.2
Kimelberg, H.3
-
12
-
-
0029988431
-
Influence of cholesterol on the association of plasma proteins with liposomes
-
Semple SC, Chonn A, Cullis PR. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry 1996;35:2521-5
-
(1996)
Biochemistry
, vol.35
, pp. 2521-2525
-
-
Semple, S.C.1
Chonn, A.2
Cullis, P.R.3
-
13
-
-
0015495447
-
The phospholipid-cholesterol interaction kinetics of water permeability in liposomes
-
Bittman R, Blau L. The phospholipid-cholesterol interaction. Kinetics of water permeability in liposomes. Biochemistry 1972;11:4831-9
-
(1972)
Biochemistry
, vol.11
, pp. 4831-4839
-
-
Bittman, R.1
Blau, L.2
-
14
-
-
0015795402
-
Phase transitions in phospholipids vesicles fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
-
Papahadjopoulos D, Jacobson K, Nir S, Isac T. Phase transitions in phospholipids vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. Biochim Biophys Acta 1973;11:330-48
-
(1973)
Biochim. Biophys. Acta.
, vol.11
, pp. 330-348
-
-
Papahadjopoulos, D.1
Jacobson, K.2
Nir, S.3
Isac, T.4
-
16
-
-
0019324697
-
Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro
-
Kirby C, Clarke J, Gregoriadis G. Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro. Biochem J 1980;186:591-8
-
(1980)
Biochem. J.
, vol.186
, pp. 591-598
-
-
Kirby, C.1
Clarke, J.2
Gregoriadis, G.3
-
17
-
-
0019951707
-
Stability of small unilamellar liposomes in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components
-
Senior J, Gregoriadis G. Stability of small unilamellar liposomes in serum and clearance from the circulation: The effect of the phospholipid and cholesterol components. Life Sci 1982;30:2123-36
-
(1982)
Life Sci.
, vol.30
, pp. 2123-2136
-
-
Senior, J.1
Gregoriadis, G.2
-
18
-
-
0024363912
-
Cholesterol enhances the delivery of liposome-encapsulated gallium-67 to tumors
-
Ogihara-Umeda I, Kojima S. Cholesterol enhances the delivery of liposome-encapsulated gallium-67 to tumors. Eur J Nucl Med 1989;15:612-17
-
(1989)
Eur. J. Nucl. Med.
, vol.15
, pp. 612-617
-
-
Ogihara-Umeda, I.1
Kojima, S.2
-
19
-
-
33847049076
-
Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo
-
Tardi PG, Gallagher RC, Johnstone SA, et al. Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo. Biochim Biophys Acta 2007;1768:678-87
-
(2007)
Biochim. Biophys. Acta.
, vol.1768
, pp. 678-687
-
-
Tardi, P.G.1
Gallagher, R.C.2
Johnstone, S.A.3
-
20
-
-
0037066608
-
Improved retention of idarubicin after intravenous injection obtained for cholesterol-free liposomes
-
Dos Santos N, Mayer LD, Abraham SA, et al. Improved retention of idarubicin after intravenous injection obtained for cholesterol-free liposomes. Biochim Biophys Acta 2002;1561:188-201
-
(2002)
Biochim. Biophys. Acta.
, vol.1561
, pp. 188-201
-
-
Dos Santos, N.1
Mayer, L.D.2
Abraham, S.A.3
-
21
-
-
20444396580
-
Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity
-
Dos Santos N, Waterhouse D, Masin D, et al. Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity. J Control Release 2005;105:89-105
-
(2005)
J. Control Release
, vol.105
, pp. 89-105
-
-
Dos Santos, N.1
Waterhouse, D.2
Masin, D.3
-
22
-
-
0028053658
-
Factors influencing the retention and chemical stability of poly ethylene glycol-lipid conjugates incorporated into large unilamellar vesicles
-
Parr MJ, Ansell SM, Choi LS, et al. Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles. Biochim Biophys Acta 1994;1195:21-30
-
(1994)
Biochim. Biophys. Acta.
, vol.1195
, pp. 21-30
-
-
Parr, M.J.1
Ansell, S.M.2
Choi, L.S.3
-
23
-
-
33750345700
-
Accelerated blood clearance of pegylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection
-
Ishida T, Atobe K, Wang X, et al. Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin- encapsulation and high-dose first injection. J Control Release 2006;115:251-8
-
(2006)
J. Control Release
, vol.115
, pp. 251-258
-
-
Ishida, T.1
Atobe, K.2
Wang, X.3
-
24
-
-
33645815708
-
Injection of pegylated liposomes in rats elicits PEG-specific IgM which is responsible for rapid elimination of a second dose of pegylated liposomes
-
Ishida T, Ichihara M, Wang X, et al. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J Control Release 2006;112:15-25
-
(2006)
J. Control Release
, vol.112
, pp. 15-25
-
-
Ishida, T.1
Ichihara, M.2
Wang, X.3
-
25
-
-
0034047673
-
Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose
-
Laverman P, Brouwers AH, Dams ET, et al. Preclinical and clinical evidence for disappearance of long-circulating characteristics of polyethylene glycol liposomes at low lipid dose. J Pharmacol Exp Ther 2000;293:996-1001
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.293
, pp. 996-1001
-
-
Laverman, P.1
Brouwers, A.H.2
Dams, E.T.3
-
26
-
-
0028855939
-
Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models
-
Webb MS, Harasym TO, Masin D, et al. Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models. Br J Cancer 1995;72:896-904
-
(1995)
Br. J. Cancer
, vol.72
, pp. 896-904
-
-
Webb, M.S.1
Harasym, T.O.2
Masin, D.3
-
27
-
-
0031689827
-
Comparison of different hydrophobic anchors conjugated to poly ethyleneglycol: Effects on the pharmacokinetics of liposomal vincristine
-
Webb MS, Saxon D, Wong FM, et al. Comparison of different hydrophobic anchors conjugated to poly(ethyleneglycol): effects on the pharmacokinetics of liposomal vincristine. Biochim Biophys Acta 1998;1372:272-82
-
(1998)
Biochim. Biophys. Acta.
, vol.1372
, pp. 272-282
-
-
Webb, M.S.1
Saxon, D.2
Wong, F.M.3
-
28
-
-
0842279809
-
Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
-
USA
-
Gabizon A, Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci USA 1988;85:6949-53
-
(1988)
Proc. Natl. Acad. Sci.
, vol.85
, pp. 6949-6953
-
-
Gabizon, A.1
Papahadjopoulos, D.2
-
29
-
-
0026778635
-
Association of blood proteins with large unilamellar liposomes in vivo relation to circulation lifetimes
-
Chonn A, Semple SC, Cullis PR. Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. J Biol Chem 1992;267:18759-65
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 18759-18765
-
-
Chonn, A.1
Semple, S.C.2
Cullis, P.R.3
-
30
-
-
0026570605
-
The role of surface charge and hydrophilic groups on liposome clearance in vivo
-
Gabizon A, Papahadjopoulos D. The role of surface charge and hydrophilic groups on liposome clearance in vivo. Biochim Biophys Acta 1992;1103:94-100
-
(1992)
Biochim. Biophys. Acta.
, vol.1103
, pp. 94-100
-
-
Gabizon, A.1
Papahadjopoulos, D.2
-
31
-
-
0023280158
-
Fate and behavior of liposomes in vivo: A review of controlling factors
-
Senior JH. Fate and behavior of liposomes in vivo: a review of controlling factors. Crit Rev Ther Drug Carrier Syst 1987;3:123-93
-
(1987)
Crit. Rev. Ther. Drug. Carrier. Syst.
, vol.3
, pp. 123-193
-
-
Senior, J.H.1
-
32
-
-
0032758610
-
Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors
-
Drummond DC, Meyer O, Hong K, et al. Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors. Pharmacol Rev 1999;51:691-743
-
(1999)
Pharmacol. Rev.
, vol.51
, pp. 691-743
-
-
Drummond, D.C.1
Meyer, O.2
Hong, K.3
-
33
-
-
77952921113
-
Phase 2b randomized study of CPX-351 vs. conventional cytarabine + daunorubicin in newly diagnosed AML patients aged 60-75: Safety report
-
Lancet J, Feldman E, Cortes J, et al. Phase 2b randomized study of CPX-351 vs. conventional cytarabine + daunorubicin in newly diagnosed AML patients aged 60-75: safety report. Blood 2009;114:2033
-
(2009)
Blood
, vol.114
, pp. 2033
-
-
Lancet, J.1
Feldman, E.2
Cortes, J.3
-
34
-
-
55049108527
-
In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy
-
Tardi PG, Johnstone SA, Harasym NL, et al. In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res 2009a;33:129-39
-
(2009)
Leuk Res.
, vol.33
, pp. 129-139
-
-
Tardi, P.G.1
Johnstone, S.A.2
Harasym, N.L.3
-
35
-
-
0021829850
-
Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential
-
Mayer LD, Bally MB, Hope MJ, et al. Uptake of antineoplastic agents into large unilamellar vesicles in response to a membrane potential. Biochim Biophys Acta 1985;813:294-302
-
(1985)
Biochim. Biophys. Acta.
, vol.813
, pp. 294-302
-
-
Mayer, L.D.1
Bally, M.B.2
Hope, M.J.3
-
36
-
-
0030886615
-
Influence of pH gradients on the transbilayer transport of drugs lipids peptides and metal ions into large unilamellar vesicles
-
Cullis PR, Hope MJ, Bally MB, et al. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles. Biochim Biophys Acta 1997;1331:187-211
-
(1997)
Biochim. Biophys. Acta.
, vol.1331
, pp. 187-211
-
-
Cullis, P.R.1
Hope, M.J.2
Bally, M.B.3
-
37
-
-
0027433668
-
Optimization of the retention properties of vincristine in liposomal systems
-
Boman NL, Mayer LD, Cullis PR. Optimization of the retention properties of vincristine in liposomal systems. Biochim Biophys Acta 1993;1152:253-8
-
(1993)
Biochim. Biophys. Acta.
, vol.1152
, pp. 253-258
-
-
Boman, N.L.1
Mayer, L.D.2
Cullis, P.R.3
-
38
-
-
0027514941
-
Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases
-
Haran G, Cohen R, Bar LK, et al. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993;1151(2):201-15
-
(1993)
Biochim. Biophys. Acta.
, vol.1151
, Issue.2
, pp. 201-215
-
-
Haran, G.1
Cohen, R.2
Bar, L.K.3
-
39
-
-
0032508919
-
Loading of doxorubicin into liposomes by forming Mn2+-drug complexes
-
Cheung BCL, Sun THT, Leenhouts JM, et al. Loading of doxorubicin into liposomes by forming Mn2+-drug complexes. Biochim Biophys Acta 1998;1414:204-16
-
(1998)
Biochim. Biophys. Acta.
, vol.1414
, pp. 204-216
-
-
Cheung, B.C.L.1
Sun, T.H.T.2
Leenhouts, J.M.3
-
40
-
-
0027377645
-
Chemical stability of liposoms: Implications for their physical stability
-
Grit M, Crommelin DJ. Chemical stability of liposoms: implications for their physical stability. Chem Phys Lipids 1993;64(1-3):3-18
-
(1993)
Chem. Phys. Lipids
, vol.64
, Issue.1-3
, pp. 3-18
-
-
Grit, M.1
Crommelin, D.J.2
-
41
-
-
0027196444
-
Stability of liposomal doxorubicin formulations: Problems and prospects
-
Barenholz Y, Amselem S, Goren D, et al. Stability of liposomal doxorubicin formulations: problems and prospects. Med Res Rev 1993;13(4):449-91
-
(1993)
Med. Res. Rev.
, vol.13
, Issue.4
, pp. 449-491
-
-
Barenholz, Y.1
Amselem, S.2
Goren, D.3
-
42
-
-
0002829160
-
Role of metal-binding in the biological activities of drugs
-
Foye WO. Role of metal-binding in the biological activities of drugs. J Pharm Sci 1961;50:93-108
-
(1961)
J. Pharm. Sci.
, vol.50
, pp. 93-108
-
-
Foye, W.O.1
-
43
-
-
0035828871
-
Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems
-
Drechsel H, Fiallo M, Garnier-Suillerot A, et al. Spectroscopic studies on iron complexes of different anthracyclines in aprotic solvent systems. Inorg Chem 2001;40:5324-33
-
(2001)
Inorg. Chem.
, vol.40
, pp. 5324-5333
-
-
Drechsel, H.1
Fiallo, M.2
Garnier-Suillerot, A.3
-
44
-
-
0022552017
-
Metal anthracycline complexes as a new class of anthracycline derivatives Pd II-adriamycin and Pd II-daunorubicin complexes: Physicochemical characteristics and antitumor activity
-
Fiallo MM, Garnier-Suillerot A. Metal anthracycline complexes as a new class of anthracycline derivatives. Pd(II)-adriamycin and Pd(II)- daunorubicin complexes: physicochemical characteristics and antitumor activity. Biochemistry 1986;25:924-30
-
(1986)
Biochemistry
, vol.25
, pp. 924-930
-
-
Fiallo, M.M.1
Garnier-Suillerot, A.2
-
45
-
-
0027315895
-
Interactions of iron-anthracycline complexes with living cells: A microspectrofluorometric study
-
Fiallo M, Laigle A, Garnier-Suillerot A, et al. Interactions of iron-anthracycline complexes with living cells: a microspectrofluorometric study. Biochim Biophys Acta 1993;1177:236-44
-
(1993)
Biochim. Biophys. Acta.
, vol.1177
, pp. 236-244
-
-
Fiallo, M.1
Laigle, A.2
Garnier-Suillerot, A.3
-
47
-
-
0029114832
-
Production of hydroxyl radical by iron III-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system
-
Malisza KL, Hasinoff BB. Production of hydroxyl radical by iron(III)-anthraquinone complexes through self-reduction and through reductive activation by the xanthine oxidase/hypoxanthine system. Arch Biochem Biophys 1995;321:51-60
-
(1995)
Arch. Biochem. Biophys.
, vol.321
, pp. 51-60
-
-
Malisza, K.L.1
Hasinoff, B.B.2
-
48
-
-
77952888216
-
Biophysical characterization of a liposomal formulation of cytarabine and daunorubicin
-
Dicko A, Kwak S, Frazier A, et al. Biophysical characterization of a liposomal formulation of cytarabine and daunorubicin. Int J Pharm 2010;391:248-59
-
(2010)
Int. J. Pharm.
, vol.391
, pp. 248-259
-
-
Dicko, A.1
Kwak, S.2
Frazier, A.3
-
49
-
-
0034998390
-
Phase I-II study of pegylated liposomal cisplatin SPI-077 in patients with inoperable head and neck cancer
-
Harrington KJ, Lewanski CR, Northcote AD, et al. Phase I-II study of pegylated liposomal cisplatin (SPI-077) in patients with inoperable head and neck cancer. Ann Oncol 2001;12:493-96
-
(2001)
Ann. Oncol.
, vol.12
, pp. 493-496
-
-
Harrington, K.J.1
Lewanski, C.R.2
Northcote, A.D.3
-
50
-
-
33749364608
-
Phase II study of SPI-77 sterically stabilised liposomal cisplatin in advanced non-small-cell lung cancer
-
White SC, Lorigan P, Margison GP, et al. Phase II study of SPI-77 (sterically stabilised liposomal cisplatin) in advanced non-small-cell lung cancer. Br J Cancer 2006;95:822-8
-
(2006)
Br. J. Cancer
, vol.95
, pp. 822-828
-
-
White, S.C.1
Lorigan, P.2
Margison, G.P.3
-
51
-
-
77950546060
-
Phase II study of liposomal cisplatin SPI-77 in platinum-sensitive recurrences of ovarian cancer
-
Seetharamu N, Kim E, Hochster H, et al. Phase II study of liposomal cisplatin (SPI-77) in platinum-sensitive recurrences of ovarian cancer. Anticancer Res 2010;30:541-5
-
(2010)
Anticancer Res.
, vol.30
, pp. 541-545
-
-
Seetharamu, N.1
Kim, E.2
Hochster, H.3
-
52
-
-
68849123638
-
Drug ratio-dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo
-
Tardi PG, Dos Santos N, Harasym TO, et al. Drug ratio-dependent antitumor activity of irinotecan and cisplatin combinations in vitro and in vivo. Mol Cancer Ther 2009b;8:2266-75
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2266-2275
-
-
Tardi, P.G.1
Dos Santos, N.2
Harasym, T.O.3
-
53
-
-
34548685592
-
Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios
-
Harasym TO, Tardi PG, Harasym NL, et al. Increased preclinical efficacy of irinotecan and floxuridine coencapsulated inside liposomes is associated with tumor delivery of synergistic drug ratios. Oncol Res 2007a;16:361-74
-
(2007)
Oncol. Res.
, vol.16
, pp. 361-374
-
-
Harasym, T.O.1
Tardi, P.G.2
Harasym, N.L.3
-
54
-
-
78649968366
-
Synergistic cytarabine: Daunorubicin ratios delivered by CPX-351 to human leukemia xenografts is associated with liposome-mediated bone marrow drug accumulation intracellular delivery of encapsulated agents to leukemia cells and increased efficacy
-
Mayer LD, Lim WS, Dos Santos N, et al. Synergistic cytarabine: daunorubicin ratios delivered by CPX-351 to human leukemia xenografts is associated with liposome-mediated bone marrow drug accumulation, intracellular delivery of encapsulated agents to leukemia cells, and increased efficacy. Blood 2008;112:942
-
(2008)
Blood
, vol.112
, pp. 942
-
-
Mayer, L.D.1
Lim, W.S.2
Dos Santos, N.3
-
55
-
-
77955280642
-
Leukemia-selective uptake and cytotoxicity of CPX-351 a synergistic fixed-ratio cytarabine:daunorubicin formulation in bone marrow xenografts
-
Lim WS, Tardi PG, Dos Santos N, et al. Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts. Leuk Res 2010;34(9):1214-23
-
(2010)
Leuk Res.
, vol.34
, Issue.9
, pp. 1214-1223
-
-
Lim, W.S.1
Tardi, P.G.2
Dos Santos, N.3
-
56
-
-
67650178791
-
Pharmacokinetics of CPX-351 cytarabine/daunorubicin HCl liposome injection in the mouse
-
Bayne WF, Mayer LD, Swenson C. Pharmacokinetics of CPX-351 (cytarabine/daunorubicin HCl) liposome injection in the mouse. J Pharm Sci 2009;98:2540-8
-
(2009)
J. Pharm. Sci.
, vol.98
, pp. 2540-2548
-
-
Bayne, W.F.1
Mayer, L.D.2
Swenson, C.3
-
57
-
-
0000810037
-
Synergistic effects of CPT-11 and cisplatin or etoposide on human lung cancer cell lines and xenografts in nude mice
-
Takada M, Fukuoka M, Kudoh S, et al. Synergistic effects of CPT-11 and cisplatin or etoposide on human lung cancer cell lines and xenografts in nude mice. Proc Am Assoc Cancer Res 1992;33:226
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 226
-
-
Takada, M.1
Fukuoka, M.2
Kudoh, S.3
-
58
-
-
0026587170
-
Effects of CPT-11 in combination with other anti-cancer agents in culture
-
Kano Y, Suzuki K, Akutsu M, et al. Effects of CPT-11 in combination with other anti-cancer agents in culture. Int J Cancer 1992;50:604-10
-
(1992)
Int. J. Cancer
, vol.50
, pp. 604-610
-
-
Kano, Y.1
Suzuki, K.2
Akutsu, M.3
-
60
-
-
0037050354
-
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer
-
Noda K, Nishiwaki Y, Kawahara M, et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N Engl J Med 2002;346:85-91
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 85-91
-
-
Noda, K.1
Nishiwaki, Y.2
Kawahara, M.3
-
61
-
-
33646447066
-
Randomized phase III trial comparing irinotecan/cisplatin with etoposide/cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer
-
Hanna N, Bunn PA Jr, Langer C, et al. Randomized phase III trial comparing irinotecan/cisplatin with etoposide/ cisplatin in patients with previously untreated extensive-stage disease small-cell lung cancer. J Clin Oncol 2006;24:2038-43
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 2038-2043
-
-
Hanna, N.1
Bunn Jr., P.A.2
Langer, C.3
-
62
-
-
64249110505
-
SO124: A randomized phase III trial comparing irinotecan/cisplatin IP with etoposide/cisplatin EP in patients with previously untreated extensive stage small cell lung cancer E-SCLC abstract 7512
-
Natale R. SO124: a randomized phase III trial comparing irinotecan/cisplatin (IP) with etoposide/cisplatin (EP) in patients with previously untreated extensive stage small cell lung cancer (E-SCLC) [abstract 7512]. ASCO Meeting; 2008
-
(2008)
ASCO Meeting
-
-
Natale, R.1
-
63
-
-
42049090008
-
Anti proliferative activity of elacyttm CP-4055 in combination with cloretazine VNP40101M idarubicin gemcitabine irinotecan and topotecan in human leukemia and lymphoma cells
-
Adams DJ, Sandvold ML, Myhren F, et al. Anti proliferative activity of ELACYTTM (CP-4055) in combination with cloretazine (VNP40101M) idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leuk Lymphoma 2008;49:786-97
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 786-797
-
-
Adams, D.J.1
Sandvold, M.L.2
Myhren, F.3
-
64
-
-
24644453083
-
Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery
-
Fahr A, van Hoogevest P, May S, et al. Transfer of lipophilic drugs between liposomal membranes and biological interfaces: consequences for drug delivery. Eur J Pharm Sci 2005;26:251-65
-
(2005)
Eur. J. Pharm. Sci.
, vol.26
, pp. 251-265
-
-
Fahr, A.1
Van Hoogevest, P.2
May, S.3
-
65
-
-
11144283530
-
Paclitaxel quantification in mouse plasma and tissues containing liposome-entrapped paclitaxel by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetics study
-
Guo W, Johnson JL, Khan S, et al. Paclitaxel quantification in mouse plasma and tissues containing liposome-entrapped paclitaxel by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetics study. Anal Biochem 2005;336:213-20
-
(2005)
Anal. Biochem.
, vol.336
, pp. 213-220
-
-
Guo, W.1
Johnson, J.L.2
Khan, S.3
-
66
-
-
33845508580
-
Paclitaxel prodrugs: Toward smarter delivery of anticancer agents
-
Skwarczynski M, Hayashi Y, Kiso Y. Paclitaxel prodrugs: toward smarter delivery of anticancer agents. J Med Chem 2006;49:7253-69
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7253-7269
-
-
Skwarczynski, M.1
Hayashi, Y.2
Kiso, Y.3
-
67
-
-
70349386390
-
Biodegradable amphiphilic polymer-drug conjugate micelles
-
Hu X, Jing X. Biodegradable amphiphilic polymer-drug conjugate micelles. Expert Opin Drug Deliv 2009;6:1079-90
-
(2009)
Expert Opin. Drug. Deliv.
, vol.6
, pp. 1079-1090
-
-
Hu, X.1
Jing, X.2
-
69
-
-
9244234511
-
In vitro cytotoxicity and in vivo distribution after direct delivery of PEG-camptothecin conjugates to the rat brain
-
Fleming AB, Haverstick K, Saltzman WM. In vitro cytotoxicity and in vivo distribution after direct delivery of PEG-camptothecin conjugates to the rat brain. Bioconjug Chem 2004;15:1364-75
-
(2004)
Bioconjug. Chem.
, vol.15
, pp. 1364-1375
-
-
Fleming, A.B.1
Haverstick, K.2
Saltzman, W.M.3
-
70
-
-
33845229315
-
Enzymatic activation of second-generation dendritic prodrugs: Conjugation of self-immolative dendrimers with poly ethylene glycol via click chemistry
-
Gopin A, Ebner S, Attali B, et al. Enzymatic activation of second-generation dendritic prodrugs: conjugation of self-immolative dendrimers with poly(ethylene glycol) via click chemistry. Bioconjug Chem 2006;17:1432-40
-
(2006)
Bioconjug. Chem.
, vol.17
, pp. 1432-1440
-
-
Gopin, A.1
Ebner, S.2
Attali, B.3
-
71
-
-
28244465013
-
Antitumor activity of poly ethylene glycol-camptothecin conjugate: The inhibition of tumor growth in vivo
-
Yu D, Peng P, Dharap SS, et al. Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo. J Control Release 2005;110:90-102
-
(2005)
J. Control Release
, vol.110
, pp. 90-102
-
-
Yu, D.1
Peng, P.2
Dharap, S.S.3
-
72
-
-
76749138904
-
The formulation of aptamer-coated paclitaxelpolylactide nanoconjugates and their targeting to cancer cells
-
Tong R, Yala L, Fan TM, et al. The formulation of aptamer-coated paclitaxelpolylactide nanoconjugates and their targeting to cancer cells. Biomaterials 2010;31:3043-53
-
(2010)
Biomaterials
, vol.31
, pp. 3043-3053
-
-
Tong, R.1
Yala, L.2
Fan, T.M.3
-
73
-
-
84887062216
-
Development of highly efficacious hydrophobic paclitaxel prodrugs delivered in nanoparticles for fixed-ratio drug combination applications abstracts 5734
-
Ansell SM, Johnstone SA, Tardi PG, et al. Development of highly efficacious hydrophobic paclitaxel prodrugs delivered in nanoparticles for fixed-ratio drug combination applications [abstracts 5734]. AACR Meeting; 2008a
-
(2008)
AACR Meeting
-
-
Ansell, S.M.1
Johnstone, S.A.2
Tardi, P.G.3
-
74
-
-
44949198237
-
Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates
-
Ansell SM, Johnstone SA, Tardi PG, et al. Modulating the therapeutic activity of nanoparticle delivered paclitaxel by manipulating the hydrophobicity of prodrug conjugates. J Med Chem 2008b;51:3288-96
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3288-3296
-
-
Ansell, S.M.1
Johnstone, S.A.2
Tardi, P.G.3
|