The effect of syndromic management interventions on the prevalence of sexually transmitted infections in South Africa

Sexual and Reproductive Healthcare

Volumn 2, Issue 1, 2011, Pages 13-20

  Johnson, Leigh F ^a   Dorrington, Rob E ^b   Bradshaw, Debbie ^c   Coetzee, David J ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

Author keywords

Mathematical model; Sexually transmitted infection; South Africa; Syndromic management

Indexed keywords

ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; CHLAMYDIASIS; CHLAMYDOPHILA INFECTION; FEMALE; GENITAL HERPES; GONORRHEA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MATHEMATICAL MODEL; MORBIDITY; PREVALENCE; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASE; SOUTH AFRICA; SYPHILIS; TRICHOMONIASIS; ULCUS MOLLE; VAGINA CANDIDIASIS; VAGINITIS;

ADOLESCENT; ADULT; BAYES THEOREM; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MODELS, THEORETICAL; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; PREVALENCE; SEXUALLY TRANSMITTED DISEASES; SOUTH AFRICA; YOUNG ADULT;

EID: 78649914901     PISSN: 18775756     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.srhc.2010.08.006     Document Type: Article

References (80)

1. Rowley J., Berkley S. Sexually transmitted diseases. Health dimensions of sex and reproduction 1998, Harvard University Press, Boston. C.J.L. Murray, A.D. Lopez (Eds.).
2. Management of patients with sexually transmitted diseases. World Health Organ Tech Rep Ser 1991, 810:1-103. World Health Organization.
3. Mayaud P., Mabey D. Approaches to the control of sexually transmitted infections in developing countries: old problems and modern challenges. Sex Transm Infect 2004, 80(3):174-182.
4. Wasserheit J.N., Aral S.O. The dynamic topology of sexually transmitted disease epidemics: implications for prevention strategies. J Infect Dis 1996, 174(Suppl. 2):S201-S213.
5. Pettifor A., Walsh J., Wilkins V., Raghunathan P. How effective is syndromic management of STDs? A review of current studies. Sex Transm Dis 2000, 27(7):371-385.
6. Mayaud P., Mosha F., Todd J., Balira R., Mgara J., West B., et al. Improved treatment services significantly reduce the prevalence of sexually transmitted diseases in rural Tanzania: results of a randomized controlled trial. AIDS 1997, 11(15):1873-1880.
7. Kamali A., Quigley M., Nakiyingi J., Kinsman J., Kengeya-Kayondo J., Gopal R., et al. Syndromic management of sexually-transmitted infections and behaviour change interventions on transmission of HIV-1 in rural Uganda: a community randomized trial. Lancet 2003, 361:645-652.
8. Creek T.L., Thuku H., Kolou B., Rahman M., Kilmarx P.H. Declining syphilis prevalence among pregnant women in northern Botswana: an encouraging sign for the HIV epidemic?. Sex Transm Infect 2005, 81(6):453-455.
9. Paz-Bailey G., Rahman M., Chen C., Ballard R., Moffat H.J., Kenyon T., et al. Changes in the etiology of sexually transmitted diseases in Botswana between 1993 and 2002: implications for the clinical management of genital ulcer disease. Clin Infect Dis 2005, 41(9):1304-1312.
10. Taha T.E., Dallabetta G.A., Hoover D.R., Chiphangwi J.D., Mtimavalye L.A.R., Liomba G.N., et al. Trends in HIV-1 and sexually transmitted diseases among pregnant and postpartum women in urban Malawi. AIDS 1998, 12:197-203.
11. Moses S, Ngugi E, Costigan A, Kariuki C, Ronald A, MacLean I, et al. Declining sexually transmitted disease and HIV prevalences among antenatal and family planning clinic attenders in Nairobi, Kenya, from 1992-1999. In: XIII International AIDS Conference, 9-14 July, 2000, Durban, South Africa.
12. Meda N., Ndoye I., M'Boup S., Wade A., Ndiaye S., Niang C., et al. Low and stable HIV infection rates in Senegal: natural course of the epidemic or evidence for success of prevention?. AIDS 1999, 13(11):1397-1405.
13. Sturm A, Moodley P, Sturm P, Karim F, Khan N. Trends in the prevalence of sexually transmitted infections and HIV in pregnant women in KwaZulu/Natal from 1995 to 2002. In: South African AIDS Conference, 3-6 August, 2003, Durban, South Africa.
14. Korenromp E.L., Bakker R., de Vlas S.J., Gray R.H., Wawer M.J., Serwadda D., et al. HIV dynamics and behaviour change as determinants of the impact of sexually transmitted disease treatment on HIV transmission in the context of the Rakai trial. AIDS 2002, 16:2209-2218.
15. Chesson H.W., Dee T.S., Aral S.O. AIDS mortality may have contributed to the decline in syphilis rates in the United States in the 1990s. Sex Transm Dis 2003, 30(5):419-424.
16. Korenromp E.L., White R.G., Orroth K.K., Bakker R., Kamali A., Serwadda D., et al. Determinants of the impact of sexually transmitted infection treatment on prevention of HIV infection: a synthesis of evidence from the Mwanza, Rakai, and Masaka intervention trials. J Infect Dis 2005, 191(Suppl. 1):S168-S178.
17. White R.G., Orroth K.K., Korenromp E.L., Bakker R., Wambura M., Sewankambo N.K., et al. Can population differences explain the contrasting results of the Mwanza, Rakai, and Masaka HIV/sexually transmitted disease intervention trials? A modeling study. J Acquir Immune Defic Syndr 2004, 37(4):1500-1513.
18. Gray R.H., Wawer M.J. Reassessing the hypothesis on STI control for HIV prevention. Lancet 2008, 371(9630):2064-2065.
19. Department of Health. National HIV and syphilis prevalence survey, South Africa, 2005. Directorate of Epidemiology and Surveillance, Pretoria, 2006. ; 2010 [accessed 06.08.10]. http://www.doh.gov.za/docs/reports-f.html.
20. Johnson L.F., Coetzee D.J., Dorrington R.E. Sentinel surveillance of sexually transmitted infections in South Africa: a review. Sex Transm Infect 2005, 81:287-293.
21. Johnson L.F., Dorrington R.E., Bradshaw D., Pillay-Van Wyk V., Rehle T.M. Sexual behaviour patterns in South Africa and their association with the spread of HIV: insights from a mathematical model. Demogr Res 2009, 21:289-340.
22. Department of Health. South Africa Demographic and Health Survey, 1998: full report, 1999. ; 2010 [accessed 06.08.10]. http://www.doh.gov.za/docs/reports-f.html.
23. Department of Health. South Africa Demographic and Health Survey, 2003: preliminary report, Pretoria, 2004. <>; 2006 [accessed 17.06.06]. http://www.doh.gov.za/docs/.
24. Shisana O, Rehle T, Simbayi LC, Parker W, Zuma K, Bhana A, et al. South African national HIV prevalence, HIV incidence, behaviours and communication survey. Cape Town: HSRC Press. ; 2005 [accessed 01.12.05]. http://www.hsrcpress.ac.za.
25. Kaufman CE. The politics and practice of reproductive control in South Africa: a multilevel analysis of fertility and contraceptive use. Doctoral thesis, University of Michigan, Ann Arbor; 1996.
26. Katz I., Low-Beer D. Why has HIV stabilized in South Africa, yet not declined further? Age and sexual behavior patterns among youth. Sex Transm Dis 2008, 35(10):837-842.
27. Johnson LF. The interaction between HIV and other sexually transmitted infections in South Africa: a model-based evaluation. Doctoral thesis, University of Cape Town, Cape Town, 2008. ; 2010 [accessed 06.08.10]. http://www.commerce.uct.ac.za/Research_Units/CARE/2009/ThesisLJfinal.pdf.
28. Johnson L.F., Alkema L., Dorrington R.E. A Bayesian approach to uncertainty analysis of sexually transmitted infection models. Sex Transm Infect 2010, 86(3):169-174.
29. Williams B, Gilgen D, Campbell C, Taljaard D, MacPhail C. The natural history of HIV/AIDS in South Africa: a biomedical and social survey in Carletonville. Council for Scientific and Industrial Research, Johannesburg; 2000.
30. Wilkinson D., Connolly A., Harrison A., Lurie M., Abdool Karim S.S. Sexually transmitted disease syndromes in rural South Africa: results from health facility surveillance. Sex Transm Dis 1998, 25:20-23.
31. O'Farrell N., Hoosen A.A., Coetzee K.D., Van den Ende J. Genital ulcer disease in women in Durban, South Africa. Genitourin Med 1991, 67:322-326.
32. O'Farrell N., Hoosen A.A., Coetzee K.D., Van den Ende J. Genital ulcer disease in men in Durban, South Africa. Genitourin Med 1991, 67:327-330.
33. Reddy SP, Panday S, Swart D, Jinabhai CC, Amosun SL, James S, et al. Umthenthe Uhlaba Usamila - the South African Youth Risk Behaviour Survey, 2002. Cape Town: South African Medical Research Council. ; 2003 [accessed 15.12.03]. http://www.mrc.ac.za/healthpromotion/healthpromotion.htm.
34. Lewis J.J., Garnett G.P., Nyamukapa C.A., Donnelly C.A., Mason P.R., Gregson S. Patterns of uptake of treatment for self reported sexually transmitted infection symptoms in rural Zimbabwe. Sex Transm Infect 2005, 81(4):326-332.
35. Wilkinson D., Wilkinson N. HIV infection among patients with sexually transmitted diseases in rural South Africa. Int J STD AIDS 1998, 9(12):736-739.
36. Wilson T., Strebel A., Simbayi L., Andipatin M., Potgieter C., Ratele K., et al. Health care-seeking behaviour for sexually transmitted diseases in South Africa. J Psychol Afr 2000, 10(2):101-121.
37. Ndhlovu L, Searle C, Van Dam J, Mzaidume Y, Rasego B, Moema S. Reducing the transmission of HIV and sexually transmitted infections in a mining community: findings from the Carletonville Mothusimpilo intervention project: 1998 to 2001. Washington, DC: Population Council; 2005. ; 2006 [accessed 01.12.06]. http://www.popcouncil.org/pdfs/horizons/crltnvll.pdf.
38. Hudson C.P. Syndromic management for sexually transmitted diseases: back to the drawing board. Int J STD AIDS 1999, 10(7):423-434.
39. Wilkinson D., Abdool Karim S., Lurie M., Harrison A. Public-private health sector partnerships for STD control in South Africa - perspectives from the Hlabisa experience. S Afr Med J 2001, 91(517-520).
40. Ramkissoon A, Kleinschmidt I, Beksinska M, Smit J, Hlazo J, Mabude Z. National baseline assessment of sexually transmitted infection and HIV services in South African public sector health facilities. Durban: Reproductive Health Research Unit. ; 2004 [accessed 13.02.04]. http://www.rhru.co.za.
41. Reagon G, Irlam J, Levin J. The National Primary Health Care Facilities Survey 2003. Durban: Health Systems Trust; 2004. ; 2010 [accessed 06.08.10]. http://www.hst.org.za/publications/617.
42. Schneider H., Chabikuli N., Blaauw D., Funani I., Brugha R. Sexually transmitted infections - factors associated with quality of care among private general practitioners. S Afr Med J 2005, 95(10):782-785.
43. Harrison A., Wilkinson D., Lurie M., Connolly A.M., Abdool Karim S. Improving quality of sexually transmitted disease case management in rural South Africa. AIDS 1998, 12:2329-2335.
44. Dartnall E, Schneider H, Hlatswayo Z, Clews F. STD management in the private sector: a national evaluation. Centre for Health Policy; 1997.
45. Pick W, Fisher B, Kowo H, Conway S, Kgosidintsi N, Weiner R. Measuring quality of care in South African clinics and hospitals. (Technical report to chapter 14 of the South African health review, 1998). Department of Community Health, University of Witwatersrand, 1998. ; 2010 [accessed 06.08.10]. http://www.hst.org.za/uploads/files/care_98.pdf.
46. Chabikuli N., Schneider H., Blaauw D., Zwi A.B., Brugha R. Quality and equity of private sector care for sexually transmitted diseases in South Africa. Health Policy Plan 2002, 17(Suppl. 1):40-46.
47. Mathews C., van Rensburg A., Schierhout G., Coetzee N., Lombard C.J., Fehler H.G., et al. An assessment of care provided by a public sector STD clinic in Cape Town. Int J STD AIDS 1998, 9:689-694.
48. Buvé A., Changalucha J., Mayaud P., Gavyole A., Mugeye K., Todd J., et al. How many patients with a sexually transmitted infection are cured by health services? A study from Mwanza region, Tanzania. Trop Med Int Health 2001, 6:971-979.
49. Somsé P., Mberyo-Yaah F., Morency P., Dubois M.J., Grésenguet G., Pépin J. Quality of sexually transmitted disease treatments in the formal and informal sectors of Bangui, Central African Republic. Sex Transm Dis 2000, 27(8):458-464.
50. Chilongozi D.A., Daly C.C., Franco L., Liomba N.G., Dallabetta G. Sexually transmitted diseases: a survey of case management in Malawi. Int J STD AIDS 1996, 7(4):269-275.
51. World Health Organization. Guidelines for the management of sexually transmitted infections, 2003. ; 2006 [accessed 03.04.06]. http://www.who.int/reproductive-health/publications/rhr_01_10_mngt_stis/guidelines_mngt_stis.pdf.
52. Department of Health. Standard treatment guidelines and essential drugs list for South Africa, Pretoria; 2003.
53. Department of Health. First line comprehensive management and control of sexually transmitted infections (STIs), Pretoria. ; 2009 [accessed 10.07.09]. http://www.nicd.ac.za/units/stirc.
54. Moodley P., Wilkinson D., Connolly C., Sturm A.W. Influence of HIV-1 coinfection on effective management of abnormal vaginal discharge. Sex Transm Dis 2003, 30:1-5.
55. Rustomjee R., Kharsany A., Connolly C., Karim S. A randomized controlled trial of azithromycin versus doxycycline/ciprofloxacin for the syndromic management of sexually transmitted infections in a resource-poor setting. J Antimicrob Chemother 2002, 49(5):875-878.
56. Ballard R.C., da L'Exposto F., Dangor Y., Fehler H.G., Miller S.D., Koornhof H.J. A comparative study of spectinomycin and erythromycin in the treatment of chancroid. J Antimicrob Chemother 1990, 26(3):429-434.
57. Schroeter A.L., Lucas J.B., Price E.V., Falcone V.H. Treatment for early syphilis and reactivity of serologic tests. JAMA 1972, 221(5):471-476.
58. Rolfs R.T., Joesoef M.R., Hendershot E.F., Rompalo A.M., Augenbraun M.H., Chiu M., et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med 1997, 337(5):307-314.
59. Klebanoff M.A., Hauth J.C., MacPherson C.A., Carey J.C., Heine R.P., Wapner R.J., et al. Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. Am J Obstet Gynecol 2004, 190(2):363-370.
60. del Palacio A., Sanz F., Sanchez-Alor G., Garau M., Calvo M.T., Boncompte E., et al. Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream. Mycoses 2000, 43(9-10):355-365.
61. Brown D., Henzl M.R., LePage M.E., Tsao L., Izu A.E., Walker K.A.M., et al. Butoconazole vaginal cream in the treatment of vulvovaginal candidiasis. J Reprod Med 1986, 31(11):1045-1048.
62. El-Din S.S., Reynolds M.T., Ashbee H.R., Barton R.C., Evans E.G. An investigation into the pathogenesis of vulvo-vaginal candidosis. Sex Transm Infect 2001, 77(3):179-183.
63. Land M., Vogel C., Gefeller O. Partitioning methods for multifactorial risk attribution. Stat Methods Med Res 2001, 10(3):217-230.
64. Johnson L.F., Bradshaw D., Dorrington R.E. The burden of disease attributable to sexually transmitted infections in South Africa in 2000. S Afr Med J 2007, 97(8):658-662.
65. White R.G., Moodley P., McGrath N., Hosegood V., Zaba B., Herbst K., et al. Low effectiveness of syndromic treatment services for curable sexually transmitted infections in rural South Africa. Sex Transm Infect 2008, 84(7):528-534.
66. White R.G., Freeman E.E., Orroth K.K., Bakker R., Weiss H.A., O'Farrell N., et al. Population-level effect of HSV-2 therapy on the incidence of HIV in sub-Saharan Africa. Sex Transm Infect 2008, 84(Suppl. 2):ii12-ii18.
67. Clark J.L., Lescano A.G., Konda K.A., Leon S.R., Jones F.R., Klausner J.D., et al. Syndromic management and STI control in urban Peru. PLoS One 2009, 4(9):e7201.
68. Romoren M., Sundby J., Velauthapillai M., Rahman M., Klouman E., Hjortdahl P. Chlamydia and gonorrhoea in pregnant Batswana women: time to discard the syndromic approach?. BMC Infect Dis 2007, 7:27.
69. Tann C.J., Mpairwe H., Morison L., Nassimu K., Hughes P., Omara M., et al. Lack of effectiveness of syndromic management in targeting vaginal infections in pregnancy in Entebbe, Uganda. Sex Transm Infect 2006, 82(4):285-289.
70. Peeling R.W., Holmes K.K., Mabey D., Ronald A. Rapid tests for sexually transmitted infections (STIs): the way forward. Sex Transm Infect 2006, 82(Suppl. 5):v1-v6.
71. Greer L., Wendel G.D. Rapid diagnostic methods in sexually transmitted infections. Infect Dis Clin North Am 2008, 22(4):601-617.
72. Donovan B. Sexually transmissible infections other than HIV. Lancet 2004, 363(9408):545-556.
73. Coovadia Y.M., Kharsany A., Hoosen A. The microbial aetiology of genital ulcers in black men in Durban, South Africa. Genitourin Med 1985, 61:266-269.
74. Duncan M.O., Bilgeri Y.R., Fehler H.G., Ballard R.C. The diagnosis of sexually acquired genital ulcerations in black patients in Johannesburg. S Afr J Sex Transm Dis 1981, 1:20-23.
75. Crewe-Brown H.H., Adam A., Ebrahim O., Mahomed M.F., Pochee E. The aetiology of acute urethritis in a southern African general practice. S Afr J Epidemiol Infect 1991, 6:31-33.
76. Ye H., Radebe F., Fehler H.G., Ballard R.C. Changes in the pattern of sexually transmitted infection among South African mineworkers, associated with the emergence of the HIV/AIDS epidemic. S Afr Med J 2007, 97(11):1155-1160.
77. Buwa L.V., van Staden J. Antibacterial and antifungal activity of traditional medicinal plants used against venereal diseases in South Africa. J Ethnopharmacol 2006, 103(1):139-142.
78. Fernandes L., van Rensburg C.E.J., Hoosen A.A., Steenkamp V. In vitro activity of medicinal plants of the Venda region, South Africa, against Trichomonas vaginalis. S Afr J Epidemiol Infect 2008, 23(2):26-28.
79. Steenkamp V., Fernandes A.C., van Rensburg C.E.J. Screening of Venda medicinal plants for antifungal activity against Candida albicans. S Afr J Bot 2007, 73:256-258.
80. Black V., Magooa P., Radebe F., Myers M., Pillay C., Lewis D.A. The detection of urethritis pathogens among patients with the male urethritis syndrome, genital ulcer syndrome and HIV VCT clients: should South Africa's syndromic management approach be revised?. Sex Transm Infect 2008, 84(4):254-258.