Quantification of intracellular HPV E6/E7 mRNA expression increases the specificity and positive predictive value of cervical cancer screening compared to HPV DNA

Gynecologic Oncology

Volumn 120, Issue 1, 2011, Pages 89-93

  Coquillard, Gerald ^a   Palao, Bibiana ^b   Patterson, Bruce K ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Labec Pharma   (Spain)

Author keywords

CIN; E6; E7; HPV; HPV OncoTect; Hybrid Capture 2; mRNA

Indexed keywords

MESSENGER RNA; PROTEIN E6; PROTEIN E7; VIRUS DNA;

ARTICLE; CANCER DIAGNOSIS; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 31; HUMAN PAPILLOMAVIRUS TYPE 35; HUMAN PAPILLOMAVIRUS TYPE 45; HUMAN PAPILLOMAVIRUS TYPE 52; HUMAN PAPILLOMAVIRUS TYPE 58; HUMAN PAPILLOMAVIRUS TYPE 59; NONHUMAN; ONCOGENE; ONCOGENE E6; ONCOGENE E7; PREDICTION AND FORECASTING; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX CARCINOMA; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY;

CERVICAL INTRAEPITHELIAL NEOPLASIA; DNA, VIRAL; EARLY DETECTION OF CANCER; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; UTERINE CERVICAL NEOPLASMS;

EID: 78649903757     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.09.013     Document Type: Article

References (26)

1. M.J. Horner, L.A.G. Ries, and M. Krapcho SEER Cancer Statistics Review 1975-2006 2009 National Cancer Institute
2. C.D. Runowicz, and S. Garozzo Human papillomavirus testing for primary cervical cancer screening Curr Oncol Rep 10 2008 533 537
3. T.C. Wright Jr., A. Lorincz, and D.G. Ferris Reflex human papillomavirus deoxyribonucleic acid testing in women with abnormal Papanicolaou smears Am J Obstet Gynecol 178 1998 962 966
4. T.C. Wright, X.W. Sun, and J. Koulos Comparison of management algorithms for the evaluation of women with low-grade cytologic abnormalities Obstet Gynecol 85 1995 202 210
5. D. Solomon, M. Schiffman, and R. Tarone Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial J Natl Cancer Inst 93 2001 293 299 (Pubitemid 32219816)
6. M.H. Mayrand, E. Duarte-Franco, and I. Rodrigues Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer N Engl J Med 357 2007 1579 1588
7. J.T. Cox History of the use of HPV testing in cervical screening and in the management of abnormal cervical screening results J Clin Virol 45 Suppl 1 2009 S3 S12
8. K. Nanda, D.C. McCrory, and E.R. Myers Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review Ann Int Med 132 2000 810 819
9. G. Koliopolous, M. Arbyn, and P. Martin-Hirsch Diagnostic accuracy of human papillomavirus testing in primary cervical screening: a systematic review and meta-analysis of non-randomized studies Gynecol Oncol 104 2007 232 246
10. A. Szarewski, L. Ambroisine, and L. Cadman Comparison of predictors for high-grade cervical intraepithelial neoplasia in women with abnormal smears Cancer Epidemiol. Biomarkers Prev. 17 2008 3033 3042
11. P. Naucler, W. Ryd, and S. Tornberg Human papillomavirus and Papanicolaou tests to screen for cervical cancer N Engl J Med 357 2007 1589 1597
12. M. Schiffman, and D. Solomon Screening and prevention methods for cervical cancer JAMA 302 2009 1809 1810
13. M.E. Sherman, A.T. Lorincz, and D.R. Scott Baseline cytology, human papillomavirus testing, and risk for cervical neoplasia: a 10-year cohort analysis J Natl Cancer Inst 95 2003 46 52
14. G. Ronco, F. Giorgi-Rossi, and F. Carozzi Results at recruitment from a randomized controlled trial comparing human papillomavirus testing alone with conventional cytology as the primary cervical cancer screening test J Natl Cancer Inst 100 2008 492 501
15. M. Durst, D. Glitz, and A. Schneider zur HH. Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: analysis by in situ hybridization Virology 189 1992 132 140
16. K. Munger, W.C. Phelps, V. Bubb, P.M. Howley, and R. Schlegel The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes J Virol 63 1989 4417 4421 (Pubitemid 19229441)
17. R. Narimatsu, and B.K. Patterson High-throughput cervical cancer screening using intracellular human papillomavirus E6 and E7 mRNA quantification by flow cytometry Am J Clin Pathol 123 2005 716 723
18. P. Silvia, S.P. González, A. Henríquez, and R. Sainz de la Cuesta Ginecología y Obstetricia Clínica 9 2008 181 186
19. C. Kottaridi, S. Tsiodras, and J. Georgoulakis A flow cytometric method for quantification of HPV E6, E7 mRNA as a novel biomarker for cervical cancer screening Eurogin 2008 Nice, France
20. D. Grundhoefer, and B.K. Patterson Determination of liquid-based cervical cytology specimen adequacy using cellular light scatter and flow cytometry Cytometry 46 2001 340 344
21. C. Kottaridi, J. Georgoulakis, and D. Kassanos Use of flow cytometry as a quality control device for liquid-based cervical cytology specimens Cytometry B Clin. Cytom 78 2010 37 40
22. R. Polina, C. Sturgis, J. Patterson, and B.K. Patterson Rapid, high throughput determination of cervical cytology specimen adequacy using a capillary-based cytometer Cytometry B Clin Cytom. 74 2008 133 136
23. K. Sotlar, A. Stubner, and D. Diemer Detection of high-risk human papillomavirus E6 and E7 oncogene transcripts in cervical scrapes by nested RT-polymerase chain reaction J Med Virol 74 2004 107 116
24. S. Nakagawa, H. Yoshikawa, and T. Yasugi Ubiquitous presence of E6 and E7 transcripts in human papillomavirus-positive cervical carcinomas regardless of its type J Med Virol 62 2000 251 258
25. Q. Sun, S.C. Tang, M.M. Pater, and A. Pater Different HPV16 E6/E7 oncogene expression patterns in epithelia reconstructed from HPV16-immortalized human endocervical cells and genital keratinocytes Oncogene 15 1997 2399 2408
26. M.H. Stoler, C.R. Rhodes, A. Whitbeck, S.M. Wolinsky, L.T. Chow, and T.R. Broker Human papillomavirus type 16 and 18 gene expression in cervical neoplasias Hum Pathol 23 1992 117 128