Minocycline prevents osmotic demyelination syndrome by inhibiting the activation of microglia

Journal of the American Society of Nephrology

Volumn 21, Issue 12, 2010, Pages 2090-2098

  Suzuki, Haruyuki ^a   Sugimura, Yoshihisa ^a   Iwama, Shintaro ^a   Suzuki, Hiromi ^b   Nobuaki, Ozaki ^a   Nagasaki, Hiroshi ^a   Arima, Hiroshi ^a   Sawada, Makoto ^b   Oiso, Yutaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MACROPHAGE ELASTASE; MINOCYCLINE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL ACTIVATION; DEMYELINATING DISEASE; DRUG MECHANISM; HISTOPATHOLOGY; HYPONATREMIA; MALE; MICROGLIA; NONHUMAN; OSMOTIC DEMYELINATION SYNDROME; PRIORITY JOURNAL; RAT;

EID: 78649877212     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010040438     Document Type: Article

References (30)

1. Norenberg MD, Leslie KO, Robertson AS: Association between rise in serum sodium and central pontine myelinolysis. Ann Neurol 11: 128-135, 1982
2. Wright DG, Laureno R, Victor M: Pontine and extrapontine myelinolysis. Brain 102: 361-385, 1979
3. Sterns RH, Cappuccio JD, Silver SM, Cohen EP: Neurologic sequelae after treatment of severe hyponatremia: A multicenter perspective. J Am Soc Nephrol 4: 1522-1530, 1994
4. Mohmand HK, Issa D, Ahmad Z, Cappuccio JD, Kouides RW, Sterns RH: Hypertonic saline for hyponatremia: Risk of inadvertent overcorrection. Clinical J Am Soc Nephrol 2: 1110-1117, 2007
5. Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS, Orlandi C; SALT Investigators: Tolvaptan, a selective oral vasopressin V-2-receptor antagonist, for hyponatremia. N Engl J Med. 355: 2099-2112, 2006
6. Berl T, Quittnat-Pelletier F, Verbalis JG, Schrier RW, Bichet DG, Ouyang J, Czerwiec FS: Oral tolvaptan is safe and effective in chronic hyponatremia. J Am Soc Nephrol 21: 705-712, 2010
7. Sterns RH, Nigwekar SU, Hix JK: The Treatment of Hyponatremia. Semin Nephrol. 29: 282-299, 2009
8. Sugimura Y, Murase T, Takefuji S, Hayasaka S, Takagishi Y, Oiso Y, Murata Y: Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp Neurol 192: 178-183, 2005
9. Takefuji S, Murase T, Sugimura Y, Takagishi Y, Hayasaka S, Oiso Y, Murata Y: Role of microglia in the pathogenesis of osmotic-induced demyelination. Exp Neurol 204: 88-94, 2007
10. Yong VW, Wells J, Giuliani F, Casha S, Power C, Metz LM: The promise of minocycline in neurology. Lancet Neurol 3: 744-751, 2004
11. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J: Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A 95: 15769-15774, 1998
12. Brundula V, Rewcastle NB, Metz LM, Bernard CC, Yong VW: Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis. Brain 125: 1297-1308, 2002
13. Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, Ramer MS, Tetzlaff W: Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24: 2182-2190, 2004
14. Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S: Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci 22: 1763-1771, 2002
15. Chen M, Ona VO, Li MW, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JHJ, Friedlander, RM: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 6: 797-801, 2000
16. Zhu S, Stavrovskaya IG, Drozda M, Kim BYS, Ona V, Li MW, Sarang S, Liu AS, Hartley DM, Du CW, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM: Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417: 74-78, 2002
17. Tikka TM, Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166: 7527-7533, 2001
18. Hathway GJ, Vega-Avelaira D, Moss A, Ingram R, Fitzgerald M: Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Pain 144: 110-118, 2009
19. Kremlev SG, Roberts RL, Palmer C: Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. J Neurosci Res 85: 2450-2459, 2007
20. Mitchell RM, Lee SY, Randazzo WT, Simmons Z, Connor JR: Influence of HFE variants and cellular iron on monocyte chemoattractant protein- 1. J Neuroinflamm 6: 6, 2009
21. Nutile-McMenemy N, Elfenbein A, DeLeo JA: Minocycline decreases in vitro microglial motility, beta(1)-integrin, and Kv1.3 channel expression. J Neurochem 103: 2035-2046, 2007
22. DaSilva AG, Yong VW: Matrix Metalloproteinase-12 Deficiency Worsens Relapsing-Remitting Experimental Autoimmune Encephalomyelitis in Association with Cytokine and Chemokine Dysregulation. Am J Pathol 174: 898-909, 2009
23. Asahi M, Sumii T, Fini ME, Itohara S, Lo EH: Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport 12: 3003-3007, 2001
24. Baker EA, Tian Y, Adler S, Verbalis JG: Blood-brain barrier disruption and complement activation in the brain following rapid correction of chronic hyponatremia. Exp Neurol 165: 221-230, 2000
25. Rojiani AM, Prineas JW, Cho ES: Electrolyte-induced demyelination in rats: 1. Role of the blood-brain-barrier and edema. Acta Neuropathol 88: 287-292, 1994
26. Kengne FG, Soupart A, Pochet R, Brion JP, Decaux G: Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int 76: 614-621, 2009
27. Soupart A, Penninckx R, Crenier L, Stenuit A, Perier O, Decaux G: Prevention of brain demyelination in rats after excessive correction of chronic hyponatremia by serum sodium lowering. Kidney Int 45: 193-200, 1994
28. Silver SM, Schroeder BM, Sterns RH, Rojiani AM: Myoinositol administration improves survival and reduces myelinolysis after rapid correction of chronic hyponatremia in rats. J Neuropathol Exp Neurol 65: 37-44, 2006
29. Soupart A, Silver S, Schroeder B, Sterns R, Decaux, G: Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. J Am Soc Nephrol 13: 1433-1441, 2002
30. Verbalis JG, Gullans SR: Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats. Brain Res 567: 274-282, 1991