The effects of Gemcitabine and Vinorelbine on inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) distribution of MCF-7 breast cancer cells

Acta Histochemica

Volumn 113, Issue 1, 2011, Pages 62-67

  Zeybek, Naciye Dilara ^a   Inan, Sevinc ^b   Ekerbicer, Nuran ^b   Vatansever, Hafize Seda ^b   Karakaya, Jale ^a   Muftuoglu, Sevda Fatma ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Breast cancer; ENOS; Gemcitabine; INOS; MCF 7 cells; Vinorelbine

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GEMCITABINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NAVELBINE;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPEROXIDASE STAINING; INCUBATION TIME; NICK END LABELING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION;

EID: 78649858145     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2009.07.006     Document Type: Article

References (12)

1. Ali S., El-Rayes B.F., Aranha O., Sarkar F.H., Philip P.A. Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells. Breast Cancer Res Treat 2005, 90:25-31.
2. Aapro M.S., Harper P., Johnson S.A., Vermorken J.B. Developments in cytotoxic chemotherapy: advances in treatment utilising vinorelbine. Crit Rev Oncol/Hematol 2001, 40:251-263.
3. Crowell J.A., Steele V.E., Sigman C.C., Fay J.R. Is inducible nitric oxide synthase a target for chemoprevention?. Mol Cancer Ther 2003, 2(8):815-823.
4. Dhar A., Brindley J.M., Stark C., Citro M.L., Keefer L.K., Colburn N.H. Nitric oxide does not mediate but inhibits transformation and tumor phenotype. Mol Cancer Ther 2003, 2(12):1285-1293.
5. Duenas-Gonzalez A., Isales C.M., del Mar Abad-Hernandez M., Gonzalez-Sarmiento R., Sangueza O., Rodriguez-Commes J Expression of inducible nitric oxide synthase in breast cancer correlates with metastatic disease. J Mod Pathol 1997, 10:645-649.
6. Jordan M.A., Thrower D., Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res 1991, 51:2212-2222.
7. Lechner M., Lirk P., Rieder J. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. Semin Cancer Biol 2005, 15(4):277-289.
8. Loibl S., Bratengeier J., Farines V., von Minckwitz G., Spankuch B., Schini-Kerth V., et al. Investigations on the inducible endothelial nitric oxide synthases in human breast cancer cell line MCF-7-estrogen has an influence on e-NOS, but not on i-NOS. Pathol Res Pract 2006, 202(1):1-7.
9. Oktem G., Karabulut B., Selvi N., Sezgin C., Sanli U.A., Uslu R., et al. Differential effects of doxorubicin and docetaxel on nitric oxide production and inducible nitric oxide synthase expression in MCF-7 human breast cancer cells. Oncol Res 2004, 14(7-8):381-386.
10. Reveneau S., Arnould L., Jolimoy G., Hilpert S., Lejeune P., Saint-Giorgio V., et al. Nitric oxide synthase in human breast cancer is associated with tumor grade, proliferation rate, and expression of progesterone receptors. Lab Invest 1999, 79:1215-1225.
11. Tschugguel W., Schneeberger C., Unfried G., Czerwenka K., Weninger W., Mildner M., et al. Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade. Breast Cancer Res Treat 1999, 56:145-151.
12. Vakkala M., Kahlos K., Lakari E., Paakko P., Kinnula V., Soini Y. Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas. Clin Cancer Res 2000, 6:2408-2416.