Unique structure of the M loop region of β1-tubulin may contribute to size variability of platelets in the family Felidae

Veterinary Clinical Pathology

Volumn 39, Issue 4, 2010, Pages 417-423

  Boudreaux, Mary K ^a   Osborne, Christina D ^a   Herre, Adam C ^a   Rivera, Elliot Ramos ^a   Spangler, Elizabeth A ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Cats; Megakaryocytes; Microtubules; Platelet formation

Indexed keywords

DNA; TUBULIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BLOOD; CAT; CHEMISTRY; FELIDAE; GENETICS; MICROTUBULE; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; THROMBOCYTE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOOD PLATELETS; CATS; DNA; FELIDAE; MICROTUBULES; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TUBULIN;

CANIS FAMILIARIS; FELIDAE; FELIS CATUS; MAMMALIA;

EID: 78649825183     PISSN: 02756382     EISSN: 1939165X     Source Type: Journal    
DOI: 10.1111/j.1939-165X.2010.00256.x     Document Type: Article

References (19)

1. Weiser MG, Kociba GJ. Platelet concentration and platelet volume distribution in healthy cats. Am J Vet Res. 1984;45:518-522.
2. Du Plessis L, Botha AJ, Reyers F, Stevens K. Blood platelets of the cheetah (Acinonyx jubatus). Zoo Biol. 2004;23:263-271.
3. Boudreaux MK, Ebbe S. Comparison of platelet number, mean platelet volume and platelet mass in five mammalian species. Comp Haematol Int. 1998;8:16-20.
4. Davis B, Toivio-Kinnucan M, Schuller S, Boudreaux MK. Mutation in β1-tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J Vet Intern Med. 2008;22:540-545.
5. Kunishima S, Kobayashi R, Itoh TJ, Hamaguchi M, Saito H. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. Blood. 2009;113:458-461.
6. Meurer-Grob P, Kasparian J, Wade RH. Microtubule structure at improved resolution. Biochem. 2001;40:8000-8008.
7. Italiano JE Jr., Bergmeier W, Tiwari S, et al. Mechanisms and implications of platelet discoid shape. Blood. 2003;101:4789-4796.
8. Schwer HD, Lecine P, Tiwari B, Italiano JE Jr., Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001;11:579-586.
9. Patel SR, Richardson JL, Schulze H, et al. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005;106:4076-4085.
10. Patel SR, Hartwig JH, Italiano JE Jr. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005;115:3348-3354.
11. Nogales E, Wolf SG, Downing KH. Structure of the αβ tubulin dimer by electron crystallography. Nature. 1998;391:199-203.
12. Nogales E. Structural insights into microtubule function. Annu Rev Biochem. 2000;69:277-302.
13. Gebremichael Y, Chu J-W, Voth GA. Intrinsic bending and structural rearrangement of tubulin dimer: molecular dynamics simulations and coarse-grained analysis. Biophys J. 2008;95:2487-2499.
14. Drabik P, Gusarov S, Kovalenko A. Microtubule stability studied by three-dimensional molecular theory of solvation. Biophys J. 2007;92:394-403.
15. Amos LA. Focusing-in on microtubules. Curr Opin Struct Biol. 2000;10:236-241.
16. Detrich HW III, Parker SK, Williams RC, Nogales E, Downing KH. Cold adaptation of microtubule assembly and dynamics. J Biol Chem. 2000;275:37038-37047.
17. Al-Bassam J, Ozer RS, Safer D, Halpain S, Milligan RA. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol. 2002;157:1187-1196.
18. Moreland JL, Gramada A, Buzko OV, Zhang Q, Bourne PE. The molecular biology toolkit (MBT): a modular platform for developing molecular visualization applications. BMC Bioinformatics. 2005;6:21.
19. Lowe J, Li H, Downing KH, Nogales E. Refined structure of alpha beta-tubulin at 3.5 A resolution. J Mol Biol. 2001;313:1045-1057.