The effect of HLA mismatch on highly sensitized renal allograft recipients

Clinical Transplantation

Volumn 24, Issue 6, 2010, Pages

  Paramesh, Anil S ^a   Zhang, Rubin ^a   Baber, John ^a   Yau, C L ^b   Slakey, Douglas P ^a   Killackey, Mary T ^a   Ren, Qing ^a   Sullivan, Karen ^c   Heneghan, Jean ^c   Florman, Sander S ^d  

^a Tulane Center for Abdominal Transplantation   (United States)

^b TULANE UNIVERSITY   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Acute rejection; Human leukocyte antigen mismatch; Pre sensitized

Indexed keywords

MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PANEL REACTIVE ANTIBODY; PREDNISONE; STEROID; TACROLIMUS;

ADULT; ARTICLE; CYTOMEGALOVIRUS INFECTION; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INCIDENCE; KIDNEY ALLOGRAFT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SENSITIZATION;

ADULT; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS;

EID: 78649822120     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2010.01306.x     Document Type: Article

References (16)

1. Opelz G for the Collaborative Transplant Study. Correlation of HLA matching with kidney graft survival in patients with or without cyclosporine treatment. Transplantation 1985: 40: 240.
2. Opelz G for the Collaborative Transplant Study. New immunosuppressants and HLA matching. Transplant Proc 2001: 33: 467.
3. Martins L, Fonseca I, Sousa S et al. The influence of HLA mismatches and immunosuppression on kidney graft survival: an analysis of more than 1300 patients. Transplant Proc 2007: 39: 2489.
4. Su X, Zenios SA, Chakkera H et al. Diminishing significance of HLA matching in kidney transplantation. Am J Transplant 2004: 4: 1501.
5. Akalin E. Post transplant immunosuppression in highly sensitized patients. Contrib Nephrol 2009: 162: 27.
6. Wissing KM, Fomegne G, Broeders N et al. HLA mismatches remain risk factors for acute kidney allograft rejection in patients receiving quadruple immunosuppression with anti-interleukin-2 receptor antibodies. Transplantation 2008: 85: 411.
7. Opelz G, Dohler B. Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 2007: 84: 137.
8. Available at:, Table 5.10a, Accessed February 10, 2010.
9. Takemoto SK, Terasaki PI, Gjertson DW, Cecka JM. Twelve years experience with national sharing of HLA matched cadaveric kidneys for transplantation. N Engl J Med 2000: 343: 1078.
10. Roberts JP, Wolfe RA, Bragg-Gresham JL et al. Effect of changing the priority for HLA matching on the rates and outcomes of kidney transplantation in minority groups. N Engl J Med 2004: 4: 378.
11. Mituzani K. HLA mismatches and PRA in kidney retransplants. Clin Transplant 2007: 19.
12. Meier-Kriesche H, Scornik JC, Susskind B, Rehman S, Schold JD. A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patients. Transplantation 2009: 88: 23.
13. McCune TR, Thacjer LR, Blanton JW, Adams PL. Sensitized patients require sharing of highly matched kidneys. Transplantation 2002: 73: 1891.
14. Higgins RS, Fishman JA. Disparities in solid organ transplantation for ethnic minorities: facts and solutions. Am J Transplant 2006: 6: 2556.
15. Bunnapradist S, Hong A, Lee B, Takemoto SK. Multivariate analysis of the effectiveness of using antibody induction therapy according to the degree of HLA mismatches. Transplant Proc 2005: 37: 886.
16. Brennan DC, Daller JA, Lake KD, Cibrik D, Del Castillo D. Rabbit antithymocyte globulin versus basiliximab in renal transplantation. N Engl J Med 2006: 355: 1967.