1H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine

Journal of Proteome Research

Volumn 9, Issue 12, 2010, Pages 6405-6416

  Pechlivanis, Alexandros ^a   Kostidis, Sarantos ^b   Saraslanidis, Ploutarchos ^a   Petridou, Anatoli ^a   Tsalis, George ^a   Mougios, Vassilis ^a   Gika, Helen G ^a   Mikros, Emmanuel ^b   Theodoridis, Georgios A ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID; ALANINE DERIVATIVE; AMINO ACID DERIVATIVE; BRANCHED CHAIN AMINO ACID; HYPOXANTHINE; LACTIC ACID; PYRUVIC ACID;

ADULT; ANALYTIC METHOD; ARTICLE; CATABOLISM; CITRIC ACID CYCLE; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLISM; METABOLITE; METABOLOME; METABOLOMICS; METABONOMICS; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REST; URINALYSIS;

ALANINE; CITRIC ACID; CREATININE; EXERCISE; FORMIC ACIDS; FUMARATES; HISTIDINE; HUMANS; HYDROXYBUTYRATES; HYPOXANTHINE; KETO ACIDS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; YOUNG ADULT;

ANIMALIA;

EID: 78649811837     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100684t     Document Type: Article

References (44)

1. Roepstorff, C.; Halberg, N.; Hillig, T.; Saha, A. K.; Ruderman, N. B.; Wojtaszewski, J. F.; Richter, E. A.; Kiens, B. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise Am J. Physiol. Endocrinol. Metab. 2005, 288, 133-142
2. Mikami, T.; Kitagawa, J. Intense exercise induces the degradation of adenine nucleotide and purine nucleotide synthesis via de novo pathway in the rat liver Eur. J. Appl. Physiol. 2006, 96, 543-550
3. Nicholson, J. K.; Lindon, J. C.; Holmes, E. Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29, 1181-1189
4. Nicholson, J. K.; Lindon, J. C. Systems biology: Metabonomics Nature 2008, 455, 1054-1056
5. Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function Nat. Rev. Drug Discovery 2002, 1, 253-258
6. Theodoridis, G.; Gika, H.; Wilson, I. D. LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics TrAC, Trends Anal. Chem. 2008, 27, 251-260
7. Lenz, E. M.; Wilson, I. D. Analytical Strategies in Metabonomics J. Proteome Res. 2007, 6, 443-458
8. Lindon, J.; Nicholson, J. K.; Holmes, E., Eds. The Handbook of Metabonomics and Metabolomics; Elsevier: Amsterdam, The Netherlands, 2007.
9. Dumas, M. E.; Maibaum, E. C.; Teague, C.; Ueshima, H.; Zhou, B.; Lindon, J. C.; Nicholson, J. K.; Stamler, J.; Elliot, P.; Chan, Q.; Holmes, E. Assessment of Analytical Reproducibility of 1H NMR Spectroscopy Based Metabonomics for Large-Scale Epidemiological Research: the INTERMAP Study Anal. Chem. 2006, 78, 2199-2208
10. Bertram, H. C.; Malmendal, A.; Petersen, B. O.; Madsen, J. C.; Pedersen, H.; Nielsen, N. C.; Hoppe, C.; Molgaard, C.; Michaelsen, K. F.; Duus, J. O. Effect of Magnetic Field Strength on NMR-Based Metabonomic Human Urine Data. Comparative Study of 250, 400, 500, and 800 MHz Anal. Chem. 2007, 79, 7110-7115
11. Pohjanen, E.; Thysell, E.; Jonsson, P.; Eklund, C.; Silfver, A.; Carlsson, I. B.; Lundgren, K.; Moritz, T.; Svensson, M. B.; Antti, H. A multivariate screening strategy for investigating metabolic effects of strenuous physical exercise in human serum J. Proteome Res. 2007, 6, 2113-2120
12. Lewis, G. D.; Farrell, L.; Wood, M. J.; Martinovic, M.; Arany, Z.; Rowe, G. C.; Souza, A.; Cheng, S.; McCabe, E. L.; Yang, E.; Shi, X.; Deo, R.; Roth, F. P.; Asnani, A.; Rhee, E. P.; Systrom, D. M.; Semigran, M. J.; Vasan, R. S.; Carr, S. A.; Wang, T. J.; Sabatine, M. S.; Clish, C. B.; Gerszten, R. E. Metabolic signatures of exercise in human plasma Sci. Transl. Med. 2010, 2, 33-37
13. Yan, B.; Jiye, A.; Wang, G.; Lu, H.; Huang, X.; Liu, Y.; Zha, W.; Hao, H.; Zhang, Y.; Liu, L.; Gu, S.; Huang, Q.; Zheng, Y.; Sun, J. Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training J. Appl. Physiol. 2009, 106, 531-538
14. Kirwan, G. M.; Coffey, V. G.; Niere, J. O.; Hawley, J. A.; Adams, M. J. Spectroscopic correlation analysis of NMR-based metabonomics in exercise science Anal. Chim. Acta 2009, 652, 173-179
15. Chorell, E.; Moritz, T.; Branth, S.; Antti, H.; Svensson, M. B. Predictive Metabolomics Evaluation of Nutrition-Modulated Metabolic Stress Responses in Human Blood Serum During the Early Recovery Phase of Strenuous Physical Exercise J. Proteome Res. 2009, 8, 2966-2977
16. Miccheli, A.; Marini, F.; Capuani, G.; Miccheli, A. T.; Delfini, M.; Di Cocco, M. E.; Puccetti, C.; Paci, M.; Rizzo, M.; Spataro, A. The Influence of a Sports Drink on the Postexercise Metabolism of Elite Athletes as Investigated by NMR-Based Metabolomics J. Am. Coll. Nutr. 2009, 28, 553-564
17. Huang, C. C.; Lin, W. T.; Hsu, F. L.; Tsai, P. W.; Hou, C. C. Metabolomics investigation of exercise-modulated changes in metabolism in rat liver after exhaustive and endurance exercises Eur. J. Appl. Physiol. 2010, 108, 557-566
18. Enea, C.; Seguin, F.; Petitpas-Mulliez, J.; Boildieu, N.; Boisseau, N.; Delpech, N.; Diaz, V.; Eugene, M.; Dugué, B. 1H NMR-based metabolomics approach for exploring urinary metabolome modifications after acute and chronic physical exercise Anal. Bioanal. Chem. 2010, 396, 1167-1176
19. Lee, R.; West, D.; Phillips, S. M.; Britz-McKibbin, P. Differential Metabolomics for Quantitative Assessment of Oxidative Stress with Strenuous Exercise and Nutritional Intervention: Thiol-Specific Regulation of Cellular Metabolism with N-Acetyl-l-Cysteine Pretreatment Anal. Chem. 2010, 82, 2959-2968
20. Barba, I.; de León, G.; Martín, E.; Cuevas, A.; Aguade, S.; Candell-Riera, J.; Barrabés, J. A.; Garcia-Dorado, D. Nuclear magnetic resonance-based metabolomics predicts exercise-induced ischemia in patients with suspected coronary artery disease Magn. Reson. Med. 2008, 60, 27-32
21. Coolen, S. A.; Daykin, C. A.; van Duynhoven, J. P. M.; van Dorsten, F. A.; Wulfert, F.; Mathot, J.; Scheltinga, M. R.; Stroosma, O.; Vader, H.; Wijnen, M. H. Measurement of ischaemia-reperfusion in patients with intermittent claudication using NMR-based metabonomics NMR Biomed. 2008, 21, 686-695
22. Kuhl, J.; Moritz, T.; Wagner, H.; Stenlund, H.; Lundgren, K.; Båvenholm, P.; Efendic, S.; Norstedt, G.; Tollet-Egnell, P. Metabolomics as a tool to evaluate exercise-induced improvements in insulin sensitivity Metabolomics 2008, 4, 273-282
23. Bax, A.; Davis, D. G. MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy J. Magn. Reson. 1985, 65, 355-360
24. Holmes, E.; Foxal, P. J. D.; Nicholson, J. K.; Neild, G. H.; Brown, S. M.; Beddell, C. R.; Sweatman, B. C.; Rahr, E.; Lindon, J. C.; Spraul, M.; Neidig, P. Automatic data reduction and pattern recognition methods for analysis of 1H NMR spectra of human urine from normal and pathological states Anal. Biochem. 1994, 220, 284-296
25. Lindon, J. C.; Nicholson, J. K.; Everett, J. R. NMR spectroscopy of biofluids Ann. Rep. NMR Spectrosc. 1999, 38, 2-87
26. Holmes, E.; Foxall, P. J. D.; Spraul, M.; Farrant, R. D.; Nicholson, J. K.; Lindon, J. C. 750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease J. Pharm. Biomed. Anal 1997, 15, 1647-1659
27. SIMCA-P 12, User Guide and Tutorial; Kinnelon, NJ: USA, 2008; pp 262.
28. Cloarec, O.; Dumas, M. E.; Craig, A.; Barton, R. H.; Trygg, J.; Hudson, J.; Blancher, C.; Gauguier, D.; Lindon, J. C.; Holmes, E.; Nicholson, J. K. Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic 1H NMR Data Sets Anal. Chem. 2005, 77, 1282-1289
29. Trygg, J.; Holmes, E.; Lundstedt, T. Chemometrics in Metabonomics J. Proteome Res. 2007, 6, 469-479
30. Gastin, P. B. Energy System Interaction and Relative Contribution During Maximal Exercise Sports Med. 2001, 31, 725-741
31. Liljestrand, S. H.; Wilson, D. W. The excretion of lactic acid in the urine after muscular exercise J. Biol. Chem. 1925, 65, 773-782
32. Johnson, R. E.; Edwards, H. T. Lactate and pyruvate in blood and urine after exercise J. Biol. Chem. 1937, 118, 427-432
33. Judge, M. A.; van Eys, J. Excretion of D-lactic acid by humans J. Nutr. 1962, 76, 310-313
34. Greenhaff, P. L.; Hultman, E.; Harris, R. C. Carbohydrate metabolism. In Principles of Exercise Biochemistry; Poortmans, J. R., Ed.; Karger: Basel, Switserland, 2004; pp 108 - 151.
35. Berg, J. M.; Tymoczko, J. L.; Stryer, L. Biochemistry; Freeman: New York, NY, 2002; pp 654 - 655.
36. Nicholson, J. K.; Timbrell, J. A.; Sadler, P. Proton NMR spectra of urine as indicators of renal damage mercury-induced nephrotoxicity in rats J. Mol. Pharmacol. 1985, 27, 644-651
37. Bairaktari, E.; Seferiadis, K.; Liamis, G.; Psihogios, N.; Tsolas, O.; Elisaf, M. Rhabdomyolysis-related Renal Tubular Damage Studied by Proton Nuclear Magnetic Resonance Spectroscopy of Urine Clin. Chem. 2002, 48, 1106-1109
38. Mougios, V. Exercise Biochemistry; Human Kinetics: Champaign IL, 2006; pp 216 - 218.
39. 1H-NMR spectroscopy in inborn errors of metabolism: body fluid NMR spectrum and in vivo MR spectroscopy; SPS Verlagsgesellschaft: Heilbronn, Germany, 2007; p 65.
40. Poortmans, J. R. Protein metabolism. In Principles of Exercise Biochemistry; Poortmans, J. R., Ed.; Karger: Basel, Switzerland, 2004; pp 227 - 278.
41. Pettersen, J. E.; Landaas, S.; Eldjarn, L. The occurrence of 2-hydroxybutyric acid in urine from patients with lactic acidosis Clin. Chim. Acta 1973, 48, 213-219
42. Landaas, S.; Pettersen, J. E. The occurrence of 2-hydroxyisovaleric acid in patients with lactic acidosis and ketoacidosis Scand. J. Clin. Lab. Invest. 1975, 35, 259-266
43. Ernstgård, L.; Shibata, E.; Johanson, G. Uptake and Disposition of Inhaled Methanol Vapor in Humans Toxicol. Sci. 2005, 88, 30-38
44. Dragsted, L. O. Biomarkers of meat intake and the application of nutrigenomics Meat Sci. 2010, 84, 301-307