Toxicity biomarkers among US children compared to a similar cohort in France: A blinded study measuring urinary porphyrins

Toxicological and Environmental Chemistry

Volumn 93, Issue 2, 2011, Pages 396-405

  Kern, Janet K ^a,b,c   Geier, David A ^d   Ayzac, Francoise ^e   Adams, James B ^f   Mehta, Jyutika A ^g   Geier, Mark R ^h  

^a Genetic Consultants of Dallas   (United States)

^b Autism Treatment Center   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d Institute of Chronic Illnesses Inc   (United States)

^e Autism Research Institute   (United States)

^f ARIZONA STATE UNIVERSITY   (United States)

^g TEXAS WOMAN'S UNIVERSITY   (United States)

^h Autism Spectrum Disorder Centers   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL TEXAS; ENVIRONMENTAL TOXICITY; SUBURBAN AREAS;

MERCURY (METAL); TOXICITY;

PORPHYRINS;

BIOMARKER; CHILD HEALTH; COHORT ANALYSIS; COMPARATIVE STUDY; GENOTOXICITY; LEAD; MERCURY (ELEMENT); ORGANIC COMPOUND; PORPHYRIN; SUBURBAN AREA; TOXICITY TEST; URINE;

FRANCE; TEXAS; UNITED STATES;

EID: 78649807579     PISSN: 02772248     EISSN: 10290486     Source Type: Journal    
DOI: 10.1080/02772248.2010.508609     Document Type: Article

References (43)

1. Austin, D.W., and K. Shandley. 2008. An investigation of porphyrinuria in Australian children with autism. Journal of Toxicology and Environmental Health 71: 1349-1351.
2. Barrett, R.D., L. Bennet, J. Davidson, J.M. Dean, S. George, B.S. Emerald, and A.J. Gunn. 2007. Destruction and reconstruction: Hypoxia and the developing brain. Birth Defects Research Part C: Embryo Today 81: 163-176.
3. Bigham, M., and R. Copes. 2005. Thiomersal in vaccines: Balancing the risk of adverse effects with the risk of vaccine-preventable disease. Drug Safety 28: 89-101.
4. Blaylock, R.L. 2008. A possible central mechanism in autism spectrum disorders, part 1. Alternative Therapies in Health and Medicine 14: 46-53.
5. Blaylock, R.L., and A. Struneka. 2009. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Current Medicinal Chemistry 16: 157-170.
6. Blomgren, K., and H. Hagberg. 2006. Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radical Biology and Medicine 40: 388-397.
7. Chen, W.J., K.A. King, R.E. Lee, C.S. Sedtal, and A.M. Smith. 2006. Effects of nicotine exposure during prenatal or perinatal period on cell numbers in adult rat hippocampus and cerebellum: A stereology study. Life Science 79: 2221-2227.
8. Encyclopia of the Nations. 2007. France: Energy and power. http://www.nationsencyclopedia.com/Europe/France-ENERGY-AND-POWER.html (accessed October 22, 2009).
9. Environmental News Service. 2008. Mercury is up at coal-burning power plants. http://www.ens-newswire.com/ens/nov(2008)/2008-11-21-092.asp (accessed October 25, 2009).
10. EPA. 2003. The Toxics Release Inventory (TRI) and factors to consider when using TRI data. http://www.epa.gov/TRI/tridata/tri03/brochure/brochure.htm (accessed October 26, 2000).
11. EPA. 2008. http://publicaccess.custhelp.com/cgi-in/publicaccess.cfg/php/enduser/std_adp.php?p_faqid=1821 (accessed February 12, 2009).
12. Geier, D.A., and M.R. Geier. 2006. A prospective assessment of porphyrins in autistic disorders: A potential marker for heavy metal exposure. Neurotoxicity Research 10: 57-64.
13. Geier, D.A., and M.R. Geier. 2007. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. Journal of Toxicology and Environmental Health 70: 1723-1730.
14. Geier, D.A., P.G. King, L.K. Sykes, and M.R. Geier. 2008. A comprehensive review of mercury provoked autism. Indian Journal of Medical Research 128: 383-411.
15. Geier, D.A., L.K. Sykes, and M.R. Geier. 2007. A review of thimerosal (merthiolate) and its ethylmercury breakdown product: Specific historical considerations regarding safety and effectiveness. Journal of Toxicology and Environmental Health Part B 10: 575-596.
16. Hessel, L. 2003. Mercury in vaccines. Bulletin de l'Academie Nationale de Medecine 187: 1501-1510.
17. Heyer, N.J., A.C. Bittner Jr, D. Echeverria, and J.S. Woods. 2006. A cascade analysis of the interaction of mercury and coproporphyrinogen oxidase (CPOX) polymorphism on the heme biosynthetic pathway and porphyrin production. Toxicology Letters 161: 159-166.
18. Holmes, A.S., M.F. Blaxill, and B.E. Haley. 2003. Reduced levels of mercury in first baby haircuts of autistic children. International Journal of Toxicology 22: 277-285.
19. Huang, C.F., C.J. Hsu, S.H. Liu, and S.Y. Lin-Shiau. 2008. Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: Oxidative stress and down-regulated Na{thorn}/K({thorn})-ATPase involved. Toxicology Letters 176: 188-197.
20. Institute for Vaccine Safety/Johns Hopkins Bloomberg School of Public Health. 2008. www.vaccinesafety.edu (accessed June 20, 2008).
21. Kalia, M. 2008. Brain development: Anatomy, connectivity, adaptive plasticity, and toxicity. Metabolism 57 (Suppl no. 2): S2-S5.
22. Kern, J.K., B.D. Grannemann, M.H. Trivedi, and J. Adams. 2007. Sulfhydryl-reactive metals in autism. Journal of Toxicology and Environmental Health Part A 70: 715-721.
23. Kisby, G.E., A. Olivas, T. Park, M. Churchwell, D. Doerge, L.D. Samson, S.L. Gerson, and M.S. Turker. 2009. DNA repair modulates the vulnerability of the developing brain to alkylating agents. DNA Repair 8: 400-412.
24. Laks, D.R. 2009. Assessment of chronic mercury exposure within the US population, National Health and Nutrition Examination Survey, 1999-2006. Biometals 22: 1103.
25. Latshaw, M.W., T. Glass, P. Parsons, J. Hidalgo, and B. Schwartz. 2006. Predictors of blood mercury levels in older urban residents. Journal of Occupational and Environmental Medicine 48: 715-722.
26. Leong, C.C., N.I. Syed, and F.L. Lorscheider. 2001. Retrograde degeneration of neurite membrane structural integrity of nerve growth cones following in vitro exposure to mercury. Neuroreport 12: 733-737.
27. Lidsky, T.I., and J.S. Schneider. 2003. Lead neurotoxicity in children: Basic mechanisms and clinical correlates. Brain 126: 5-19.
28. Nataf, R., C. Skorupka, L. Amet, A. Lam, A. Springbett, and R. Lathe. 2006. Porphyinuria in childhood autistic disorder: Implications for environmental toxicity. Toxicology and Applied Pharmacology 214: 99-108.
29. Olanow, C.W., and G.W. Arendash. 1994. Metals and free radicals in neurodegeneration. Current Opinion in Neurology 7: 548-558.
30. Oskarsson, A., and B.A. Fowler. 1985. Effects of lead on the heme biosynthetic pathway in rat kidney. Experimental and Molecular Pathology 43: 409-417.
31. Pingree, S.D., P.L. Simmonds, K.T. Rummel, and J.S. Woods. 2001a. Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats. Toxicological Sciences 61: 234-240.
32. Pingree, S.D., P.L. Simmonds, and J.S. Woods. 2001b. Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats. Toxicological Sciences 61: 224-233.
33. Pullela, R., J. Raber, T. Pfankuch, D.M. Ferriero, C.P. Claus, S.E. Koh, T. Yamauchi, R. Rola, J.R. Fike, and L.J. Noble-Haeusslein. 2006. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Developmental Neuroscience 28: 396-409.
34. Schopler, E., R.J. Reichler, and B.R. Renner. 1994. The Childhood Autism Rating Scale. Los Angeles, CA: Western Psychological Services.
35. Singh, V., D. Joshi, S. Shrivastava, and S. Shukla. 2007. Effect of monothiol along with antioxidant against mercury-induced oxidative stress in rat. Indian Journal of Experimental Biology 45: 1037-1044.
36. Soares, F.A., M. Farlina, F.W. Santos, D. Souza, J.B.T. Rocha, and C.W. Nogueira. 2003. Interaction between chelating agents affects glutamate binding in brain synaptic membranes. Neurochemical Research 28: 1859-1865.
37. Stringari, J., A.K. Nunes, J.L. Franco, D. Bohrer, S.C. Garcia, A.L. Dafre, D. Milatovic, et al. 2008. Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicology and Applied Pharmacology 227: 147-154.
38. United States Department of the Interior/US Geological Survey. 2002. URL: http://www.usgs.gov/themes/factsheet/146-00/ (accessed January 26, 2009).
39. US Energy Information Administration. 2009. "Form EIA-860 Database: Annual Electric Generator Report," http://www.eia.doe.gov/cneaf/electricity/page/eia860.html (accessed October 26, 2009).
40. Waly, M., H. Olteanu, R. Banjeree, S.W. Choi, J.B. Manson, B.S. Parker, S. Sukumar, et al. 2004. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopmental toxins and thimerosal. Molecular Psychiatry 9: 358-370.
41. Woods, J.S. 1996. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Canadian Journal of Physiology and Pharmacology 74: 210-215.
42. Woods, J.S., D. Echeverria, N.J. Heyer, P.L. Simmonds, J. Wilkerson, and F.M. Farin. 2005. The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicology and Applied Pharmacology 206: 113-120.
43. Youn, S.I., S.H. Jin, S.H. Kim, and S. Lim. 2010. Porphyrinuria in Korean children with autism: Correlation with oxidative stress. Journal of Toxicology and Environmental Health Part A 73: 701-710.