Targeting the midgut secreted ppchit1 reduces leishmania major development in its natural vector, the sand fly phlebotomus papatasi

PLoS Neglected Tropical Diseases

Volumn 4, Issue 11, 2010, Pages

  Coutinho Abreu, Iliano V ^a   Sharma, Narinder K ^a   Robles Murguia, Maricela ^a   Ramalho Ortigao, Marcelo ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHITINASE 1; DOUBLE STRANDED RNA; GLYCOSIDASE; UNCLASSIFIED DRUG; CHITINASE; INSECT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; FEMALE; GENETIC TRANSCRIPTION; LEISHMANIA MAJOR; LEISHMANIASIS; MIDGUT; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PARASITE VECTOR; PHLEBOTOMUS; PHLEBOTOMUS PAPATASI; RNA IMMUNIZATION; ANIMAL; BAGG ALBINO MOUSE; DIGESTIVE SYSTEM; DISEASE CARRIER; ENZYMOLOGY; GENE SILENCING; GENE TARGETING; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INSECT CONTROL; METABOLISM; PARASITOLOGY; PHYSIOLOGY;

ANIMALS; CHITINASE; DIGESTIVE SYSTEM; GENE SILENCING; GENE TARGETING; HUMANS; INSECT CONTROL; INSECT PROTEINS; INSECT VECTORS; LEISHMANIA MAJOR; LEISHMANIASIS; MICE; MICE, INBRED BALB C; PHLEBOTOMUS;

EID: 78649797228     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000901     Document Type: Article

References (36)

1. Hill CA, Kafatos FC, Stansfield SK, Collins FH (2005) Arthropod-borne diseases: vector control in the genomics era. Nat Rev Microbiol 3: 262-268.
2. Coutinho-Abreu IV, Ramalho-Ortigao M (2010) Transmission blocking vaccines to control insect-borne diseases: a review. Mem Inst Oswaldo Cruz 105: 1-12.
3. Coutinho-Abreu IV, Zhu KY, Ramalho-Ortigao M (2009) Transgenesis and paratransgenesis to control insect-borne diseases: current status and future challenges. Parasitol Int 59: 1-8.
4. Borovsky D, Schlein Y (1987) Trypsin and chymotrypsin-like enzymes of the sandfly Phlebotomus papatasi infected with Leishmania and their possible role in vector competence. Med Vet Entomol 1: 235-242.
5. Dillon RJ, Lane RP (1993) Bloodmeal digestion in the midgut of Phlebotomus papatasi and Phlebotomus langeroni. Med Vet Entomol 7: 225-232.
6. Dillon RJ, Lane RP (1993) Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni. Parasitol Res 79: 492-496.
7. Schlein Y, Jacobson RL (1998) Resistance of Phlebotomus papatasi to infection with Leishmania donovani is modulated by components of the infective bloodmeal. Parasitology 117(Pt 5): 467-473.
8. Pimenta PF, Modi GB, Pereira ST, Shahabuddin M, Sacks DL (1997) A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut. Parasitology 115(Pt 4): 359-369.
9. Lawyer PG, Ngumbi PM, Anjili CO, Odongo SO, Mebrahtu YB, et al. (1990) Development of Leishmania major in Phlebotomus duboscqi and Sergentomyia schwetzi (Diptera: Psychodidae). Am J Trop Med Hyg 43: 31-43.
10. Walters LL, Irons KP, Modi GB, Tesh RB (1992) Refractory barriers in the sand fly Phlebotomus papatasi (Diptera: Psychodidae) to infection with Leishmania panamensis. Am J Trop Med Hyg 46: 211-228.
11. Feng LC (1950) The role of the peritrophic membrane in Leishmania and Trypanosome infections in sand flies. Peking Natural History Bulletin 19: 327-334.
12. Sadlova J, Volf P (2009) Peritrophic matrix of Phlebotomus duboscqi and its kinetics during Leishmania major development. Cell Tissue Res 337: 313-325.
13. Kamhawi S (2006) Phlebotomine sand flies and Leishmania parasites: friends or foes? Trends Parasitol 22: 439-445.
14. Kamhawi S, Ramalho-Ortigao M, Pham VM, Kumar S, Lawyer PG, et al. (2004) A role for insect galectins in parasite survival. Cell 119: 329-341.
15. Pimenta PF, Saraiva EM, Rowton E, Modi GB, Garraway LA, et al. (1994) Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. Proc Natl Acad Sci U S A 91: 9155-9159.
16. Pimenta PF, Turco SJ, McConville MJ, Lawyer PG, Perkins PV, et al. (1992) Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. Science 256: 1812-1815.
17. Sacks DL, Saraiva EM, Rowton E, Turco SJ, Pimenta PF (1994) The role of the lipophosphoglycan of Leishmania in vector competence. Parasitology 108(Suppl): S55-62.
18. Myskova J, Svobodova M, Beverley SM, Volf P (2007) A lipophosphoglycanindependent development of Leishmania in permissive sand flies. Microbes Infect 9: 317-324.
19. Schlein Y, Jacobson RL, Shlomai J (1991) Chitinase secreted by Leishmania functions in the sandfly vector. Proc Biol Sci 245: 121-126.
20. Rogers ME, Hajmova M, Joshi MB, Sadlova J, Dwyer DM, et al. (2008) Leishmania chitinase facilitates colonization of sand fly vectors and enhances transmission to mice. Cell Microbiol 10: 1363-1372.
21. Ramalho-Ortigao JM, Kamhawi S, Joshi MB, Reynoso D, Lawyer PG, et al. (2005) Characterization of a blood activated chitinolytic system in the midgut of the sand fly vectors Lutzomyia longipalpis and Phlebotomus papatasi. Insect Mol Biol 14: 703-712.
22. Sacks DL (2003) Experimental Leishmania infection. In: Coligan J, Kruisbeek A, Margulies D, Shevach E, Strober W, eds. Current protocols in immunology. New York: John Wiley & Sons. pp 19.12.11-19.12.20.
23. Arakane Y, Li B, Muthukrishnan S, Beeman RW, Kramer KJ, et al. (2008) Functional analysis of four neuropeptides, EH, ETH, CCAP and bursicon, and their receptors in adult ecdysis behavior of the red flour beetle, Tribolium castaneum. Mech Dev 125: 984-995.
24. Oliveira F, Kamhawi S, Seitz AE, Pham VM, Guigal PM, et al. (2006) From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library. Vaccine 24: 374-390.
25. Svarovska A, Ant TH, Seblova V, Jecna L, Beverley SM, et al. Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors. PLoS Negl Trop Dis 4: e580.
26. Belles X (2010) Beyond Drosophila: RNAi in vivo and functional genomics in insects. Annu Rev Entomol 55: 111-128.
27. Secundino NF, Eger-Mangrich I, Braga EM, Santoro MM, Pimenta PF (2005) Lutzomyia longipalpis peritrophic matrix: formation, structure, and chemical composition. J Med Entomol 42: 928-938.
28. Ramalho-Ortigao JM, Kamhawi S, Rowton ED, Ribeiro JM, Valenzuela JG (2003) Cloning and characterization of trypsin- and chymotrypsin-like proteases from the midgut of the sand fly vector Phlebotomus papatasi. Insect Biochem Mol Biol 33: 163-171.
29. Telleria EL, Pitaluga AN, Ortigao-Farias JR, de Araujo AP, Ramalho-Ortigao JM, et al. (2007) Constitutive and blood meal-induced trypsin genes in Lutzomyia longipalpis. Arch Insect Biochem Physiol 66: 53-63.
30. Sant'anna MR, Diaz-Albiter H, Mubaraki M, Dillon RJ, Bates PA (2009) Inhibition of trypsin expression in Lutzomyia longipalpis using RNAi enhances the survival of Leishmania. Parasit Vectors 2: 62.
31. Ramalho-Ortigao JM, Traub-Cseko YM (2003) Molecular characterization of Llchit1, a midgut chitinase cDNA from the leishmaniasis vector Lutzomyia longipalpis. Insect Biochem Mol Biol 33: 279-287.
32. Molina-Cruz A, DeJong RJ, Charles B, Gupta L, Kumar S, et al. (2008) Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium. J Biol Chem 283: 3217-3223.
33. Gonzalez-Lazaro M, Dinglasan RR, Hernandez-Hernandez Fde L, Rodriguez MH, Laclaustra M, et al. (2009) Anopheles gambiae Croquemort SCRBQ2, expression profile in the mosquito and its potential interaction with the malaria parasite Plasmodium berghei. Insect Biochem Mol Biol 39: 395-402.
34. Pinto SB, Lombardo F, Koutsos AC, Waterhouse RM, McKay K, et al. (2009) Discovery of Plasmodium modulators by genome-wide analysis of circulating hemocytes in Anopheles gambiae. Proc Natl Acad Sci U S A 106: 21270-21275.
35. Pitaluga AN, Mason PW, Traub-Cseko YM (2008) Non-specific antiviral response detected in RNA-treated cultured cells of the sandfly, Lutzomyia longipalpis. Dev Comp Immunol 32: 191-197.
36. Sant'Anna MR, Alexander B, Bates PA, Dillon RJ (2008) Gene silencing in phlebotomine sand flies: Xanthine dehydrogenase knock down by dsRNA microinjections. Insect Biochem Mol Biol 38: 652-660.