Human galectin-3 (Mac-2 antigen): Defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

Biochimica et Biophysica Acta - General Subjects

Volumn 1810, Issue 2, 2011, Pages 150-161

  Krzeminski, Mickaël ^a   Singh, Tanuja ^b,c   André, Sabine ^b   Lensch, Martin ^b   Wu, Albert M ^c   Bonvin, Alexandre M J J ^a   Gabius, Hans Joachim ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF MUNICH   (Germany)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Glycosylation; Lectin; Macrophage; Modeling; Mucin; Sialylation

Indexed keywords

DISACCHARIDE; EPITOPE; GALECTIN 3; GLYCAN; GLYCOPROTEIN; TETRASACCHARIDE; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR RUNX;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARBOHYDRATE ANALYSIS; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HYDROGEN BOND; LECTIN BINDING SITE; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN CROSS LINKING; PROTEIN IMMOBILIZATION; PROTEIN LOCALIZATION; REGULATORY SEQUENCE; SIALYLATION; SOLID PHASE SYNTHESIS;

BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; COMPUTATIONAL BIOLOGY; GALECTIN 3; GLYCOPROTEINS; HUMANS; HYDROGEN BONDING; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MONOSACCHARIDES; OLIGOSACCHARIDES; POLYSACCHARIDES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 78649773993     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2010.11.001     Document Type: Article

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