Adjuvant chemoradiation versus chemotherapy in completely resected advanced gastric cancer with D2 nodal dissection

Asia-Pacific Journal of Clinical Oncology

Volumn 6, Issue 4, 2010, Pages 278-285

  Kwon, Hyuk Chan ^a,b   Kim, Min Chan ^a   Kim, Ki Han ^a   Jang, Jin Seok ^a   Oh, Sung Yong ^a,b   Kim, Sung Hyun ^a   Kwon, Kyung A ^a   Lee, Suee ^a   Lee, Hyung Sik ^a   Kim, Hyo Jin ^a  

^a Department of Internal Medicine ^*  (South Korea)

^b Dong A University College of Medicine   (South Korea)

Author keywords

Capecitabine; Chemoradiation; Gastric cancer

Indexed keywords

CAPECITABINE; CISPLATIN; FLUOROURACIL; PYRIDOXINE;

ADJUVANT CHEMOTHERAPY; ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; GASTRECTOMY; GASTROINTESTINAL TOXICITY; HAND FOOT SYNDROME; HUMAN; INTERMETHOD COMPARISON; LIVER TOXICITY; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUTROPENIA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; STOMACH CANCER; TREATMENT FAILURE; VOMITING; WEAKNESS;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; GASTRECTOMY; HUMANS; LIVER NEOPLASMS; LYMPH NODE EXCISION; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; RADIOTHERAPY, ADJUVANT; STOMACH NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 78649767679     PISSN: 17437555     EISSN: 17437563     Source Type: Journal    
DOI: 10.1111/j.1743-7563.2010.01331.x     Document Type: Article

References (20)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Won YJ, Sung J, Jung KW etal. Nationwide cancer incidence in Korea, 2003-2005. Cancer Res Treat 2009; 41: 122-31.
3. Lim L, Michael M, Mann GB, Leong T. Adjuvant therapy in gastric cancer. J Clin Oncol 2005; 23: 6220-32.
4. Ng K, Meyerhardt JA, Fuchs CS. Adjuvant and neoadjuvant approaches in gastric cancer. Cancer J 2007; 13: 168-74.
5. Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE. Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006; 24: 2903-9.
6. Bajetta E, Buzzoni R, Mariani L etal. Adjuvant chemotherapy in gastric cancer: 5-year results of a randomised study by the Italian Trials in Medical Oncology (ITMO) Group. Ann Oncol 2002; 13: 299-307.
7. Jeung HC, Moon YW, Rha SY etal. Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A:U) for locally advanced gastric cancer after curative surgery: final results of 15-year follow-up. Ann Oncol 2008; 19: 520-6.
8. Macdonald JS, Smalley SR, Benedetti J etal. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725-30.
9. Macdonald JS, Benedetti J, Smalley S etal. Chemoradiation of resected gastric cancer: a 10-year follow-up of the phase III trial INT0116 (SWOG 9008). Abstract 4515. Proc Am Soc Clin Oncol 2009; 27: 15s.
10. In: Greene FL, Page DL, Fleming ID etal. (eds). AJCC Cancer Staging Manual, 6th edn. Springer-Verlag Publisher, New York 2002; 99-106.
11. Dunst J, Reese T, Sutter T etal. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol 2002; 20: 3983-91.
12. Ichikura T, Tomimatsu S, Uefuji K etal. Evaluation of the New American Joint Committee on Cancer/International Union against cancer classification of lymph node metastasis from gastric carcinoma in comparison with the Japanese classification. Cancer 1999; 86: 553-8.
13. Arcangeli G, Saracino B, Angelini F, Marchetti P, Tirindelli Danesi D. Postoperative adjuvant chemoradiation in completely resected locally advanced gastric cancer. Int J Radiat Oncol Biol Phys 2002; 54: 1069-75.
14. Leong T, Michael M, Foo K etal. Adjuvant and neoadjuvant therapy for gastric cancer using epirubicin/cisplatin/5-fluorouracil (ECF) and alternative regimens before and after chemoradiation. Br J Cancer 2003; 89: 1433-8.
15. Kassam Z, Lockwood G, O'Brien C etal. Conformal radiotherapy in the adjuvant treatment of gastric cancer: review of 82 cases. Int J Radiat Oncol Biol Phys 2006; 65: 713-19.
16. Glynne-Jones R, Dunst J, Sebag-Montefiore D. The integration of oral capecitabine into chemoradiation regimens for locally advanced rectal cancer: how successful have we been? Ann Oncol 2006; 17: 361-71.
17. Kim S, Lim DH, Lee J etal. An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys 2005; 63: 1279-85.
18. Leong CN, Chung HT, Lee KM etal. Outcomes of adjuvant chemoradiotherapy after a radical gastrectomy and a D2 node dissection for gastric adenocarcinoma. Cancer J 2008; 14: 269-75.
19. Lee J, Kang W, Lim D etal. Phase III trial of adjuvant capecitabine/cisplatin (XP) compared with capecitabine/cisplatin/RT (XPRT) in resected gastric cancer with D2 nodal dissection (ARTIST trial): safety analysis. 2009 Abstract 5. Proc 2009 Gastrointestianl Cancers Symposium.
20. Kang YK, Kang WK, Shin DB etal. Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol 2009; 20: 666-73.