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Volumn 116, Issue 23, 2010, Pages 4916-4925

Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL

(22)  Ott, German a,b   Ziepert, Marita c   Klapper, Wolfram d   Horn, Heike b   Szczepanowski, Monika d   Bernd, Heinz Wolfram e   Thorns, Christoph e   Feller, Alfred C e   Lenze, Dido f   Hummel, Michael f   Stein, Harald f   Müller Hermelink, Hans Konrad a   Frank, Matthias g   Hansmann, Martin Leo g   Barth, Thomas F E h   Möller, Peter h   Cogliatti, Sergio i   Pfreundschuh, Michael j   Schmitz, Norbert k   Trümper, Lorenz l   more..


Author keywords

[No Author keywords available]

Indexed keywords

BCL2 RELATED PROTEIN A1; CD5 ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; INTERFERON REGULATORY FACTOR 4; KI 67 ANTIGEN; LEUKOCYTE ANTIGEN; PREDNISONE; PROTEIN BCL 6; RITUXIMAB; VINCRISTINE;

EID: 78649742465     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-276766     Document Type: Article
Times cited : (172)

References (36)
  • 3
    • 57149089307 scopus 로고    scopus 로고
    • Stromal gene signatures in large-B-cell lymphomas
    • Lenz G, Wright G, Dave SS, et al. Stromal gene signatures in large-B-cell lymphomas. N Engl J Med. 2008;359(22):2313-2323.
    • (2008) N Engl J Med , vol.359 , Issue.22 , pp. 2313-2323
    • Lenz, G.1    Wright, G.2    Dave, S.S.3
  • 4
    • 20144382754 scopus 로고    scopus 로고
    • Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response
    • Monti S, Savage KJ, Kutok JL, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood. 2005; 105(5):1851-1861.
    • (2005) Blood , vol.105 , Issue.5 , pp. 1851-1861
    • Monti, S.1    Savage, K.J.2    Kutok, J.L.3
  • 5
    • 0037142053 scopus 로고    scopus 로고
    • The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
    • Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002;346(25):1937-47.
    • (2002) N Engl J Med , vol.346 , Issue.25 , pp. 1937-1947
    • Rosenwald, A.1    Wright, G.2    Chan, W.C.3
  • 6
    • 9144237554 scopus 로고    scopus 로고
    • Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
    • Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004; 103(1):275-282.
    • (2004) Blood , vol.103 , Issue.1 , pp. 275-282
    • Hans, C.P.1    Weisenburger, D.D.2    Greiner, T.C.3
  • 7
    • 33947538494 scopus 로고    scopus 로고
    • Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: Validation of tissue microarray as a prerequisite for broad clinical applications - A study from the Lunenburg Lymphoma Biomarker Consortium
    • de Jong D, Rosenwald A, Chhanabhai M, et al. Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications - a study from the Lunenburg Lymphoma Biomarker Consortium. J Clin Oncol. 2007;25(7):805-12.
    • (2007) J Clin Oncol , vol.25 , Issue.7 , pp. 805-812
    • De Jong, D.1    Rosenwald, A.2    Chhanabhai, M.3
  • 8
    • 61449156367 scopus 로고    scopus 로고
    • Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: Validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium)
    • de Jong D, Xie W, Rosenwald A, et al. Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications (a study from the Lunenburg Lymphoma Biomarker Consortium). J Clin Pathol. 2009;62(2): 128-138.
    • (2009) J Clin Pathol , vol.62 , Issue.2 , pp. 128-138
    • De Jong, D.1    Xie, W.2    Rosenwald, A.3
  • 9
    • 38549147027 scopus 로고    scopus 로고
    • Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: A randomised controlled trial (RICOVER-60)
    • Pfreundschuh M, Schubert J, Ziepert M, et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol. 2008;9(2):105-116.
    • (2008) Lancet Oncol , vol.9 , Issue.2 , pp. 105-116
    • Pfreundschuh, M.1    Schubert, J.2    Ziepert, M.3
  • 12
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 13
    • 3343019470 scopus 로고
    • Measuring normal scale agreement among many raters
    • Fleiss JL. Measuring normal scale agreement among many raters. Psych Bull. 1971;76: 378-382.
    • (1971) Psych Bull , vol.76 , pp. 378-382
    • Fleiss, J.L.1
  • 14
    • 24044473086 scopus 로고    scopus 로고
    • Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis
    • Berglund M, Thunberg U, Amini RM, et al. Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis. Mod Pathol. 2005;18(8):1113-1120.
    • (2005) Mod Pathol , vol.18 , Issue.8 , pp. 1113-1120
    • Berglund, M.1    Thunberg, U.2    Amini, R.M.3
  • 15
    • 33845386258 scopus 로고    scopus 로고
    • Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival
    • Haarer CF, Roberts RA, Frutiger YM, et al. Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B-cell lymphoma into germinal center B-cell and nongerminal center B-cell subtypes correlates with gene expression profile and patient survival. Arch Pathol Lab Med. 2006;130(12):1819-1824.
    • (2006) Arch Pathol Lab Med , vol.130 , Issue.12 , pp. 1819-1824
    • Haarer, C.F.1    Roberts, R.A.2    Frutiger, Y.M.3
  • 16
    • 33645238948 scopus 로고    scopus 로고
    • Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma
    • Muris JJ, Meijer CJ, Vos W, et al. Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma. J Pathol. 2006;208(5):714-723.
    • (2006) J Pathol , vol.208 , Issue.5 , pp. 714-723
    • Muris, J.J.1    Meijer, C.J.2    Vos, W.3
  • 17
    • 34249673388 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy
    • Nyman H, Adde M, Karjalainen-Lindsberg ML, et al. Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy. Blood. 2007;109(11): 4930-4935.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4930-4935
    • Nyman, H.1    Adde, M.2    Karjalainen-Lindsberg, M.L.3
  • 18
    • 36248975288 scopus 로고    scopus 로고
    • Profiling of diffuse large B-cell lymphoma by immunohistochemistry: Identification of prognostic subgroups
    • DOI 10.1111/j.1600-0609.2007.00976.x
    • Sjo LD, Poulsen CB, Hansen M, et al. Profiling of diffuse large B-cell lymphoma by immunohis tochemistry: identification of prognostic subgroups. Eur J Haematol. 2007;79(6):501-507. (Pubitemid 350126679)
    • (2007) European Journal of Haematology , vol.79 , Issue.6 , pp. 501-507
    • Sjo, L.D.1    Poulsen, C.B.2    Hansen, M.3    Moller, M.B.4    Ralfkiaer, E.5
  • 19
    • 33748661970 scopus 로고    scopus 로고
    • Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poorrisk diffuse large B-cell lymphoma
    • van Imhoff GW, Boerma EJ, van der Holt B, et al. Prognostic impact of germinal center-associated proteins and chromosomal breakpoints in poorrisk diffuse large B-cell lymphoma. J Clin Oncol. 2006;24(25):4135-4142.
    • (2006) J Clin Oncol , vol.24 , Issue.25 , pp. 4135-4142
    • Van Imhoff, G.W.1    Boerma, E.J.2    Van Der Holt, B.3
  • 20
    • 34250864033 scopus 로고    scopus 로고
    • Absence of cyclin-D2 and Bcl-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients
    • Amen F, Horncastle D, Elderfield K, et al. Absence of cyclin-D2 and Bcl-2 expression within the germinal centre type of diffuse large B-cell lymphoma identifies a very good prognostic subgroup of patients. Histopathology. 2007;51(1): 70-79.
    • (2007) Histopathology , vol.51 , Issue.1 , pp. 70-79
    • Amen, F.1    Horncastle, D.2    Elderfield, K.3
  • 21
    • 0037217921 scopus 로고    scopus 로고
    • Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma
    • Colomo L, Lopez-Guillermo A, Perales M, et al. Clinical impact of the differentiation profile assessed by immunophenotyping in patients with diffuse large B-cell lymphoma. Blood. 2003; 101(1):78-84.
    • (2003) Blood , vol.101 , Issue.1 , pp. 78-84
    • Colomo, L.1    Lopez-Guillermo, A.2    Perales, M.3
  • 22
    • 27244437953 scopus 로고    scopus 로고
    • Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomas
    • de Paepe P, Achten R, Verhoef G, et al. Large cleaved and immunoblastic lymphoma may represent two distinct clinicopathologic entities within the group of diffuse large B-cell lymphomas. J Clin Oncol. 2005;23(28):7060-7068.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7060-7068
    • De Paepe, P.1    Achten, R.2    Verhoef, G.3
  • 23
    • 34347211425 scopus 로고    scopus 로고
    • Respective prognostic values of germinal center phenotype and early (18)fluorodeoxyglucose-positron emission tomography scanning in previously untreated patients with diffuse large B-cell lymphoma
    • Dupuis J, Gaulard P, Hemery F, et al. Respective prognostic values of germinal center phenotype and early (18)fluorodeoxyglucose-positron emission tomography scanning in previously untreated patients with diffuse large B-cell lymphoma. Haematologica. 2007;92(6):778-783.
    • (2007) Haematologica , vol.92 , Issue.6 , pp. 778-783
    • Dupuis, J.1    Gaulard, P.2    Hemery, F.3
  • 24
    • 38649123973 scopus 로고    scopus 로고
    • LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rituximab
    • Natkunam Y, Farinha P, Hsi ED, et al. LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rituximab. J Clin Oncol. 2008;26(3):447-454.
    • (2008) J Clin Oncol , vol.26 , Issue.3 , pp. 447-454
    • Natkunam, Y.1    Farinha, P.2    Hsi, E.D.3
  • 25
    • 34447331434 scopus 로고    scopus 로고
    • Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy
    • Veelken H, Vik DS, Schulte Moenting J, et al. Immunophenotype as prognostic factor for diffuse large B-cell lymphoma in patients undergoing clinical risk-adapted therapy. Ann Oncol. 2007; 18(5):931-939.
    • (2007) Ann Oncol , vol.18 , Issue.5 , pp. 931-939
    • Veelken, H.1    Vik, D.S.2    Schulte Moenting, J.3
  • 26
    • 53749093794 scopus 로고    scopus 로고
    • Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma
    • Fu K, Weisenburger DD, Choi WW, et al. Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma. J Clin Oncol. 2008;26(28):4587-4594.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4587-4594
    • Fu, K.1    Weisenburger, D.D.2    Choi, W.W.3
  • 27
    • 70349603639 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era
    • Seki R, Ohshima K, Fujisaki T, et al. Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era. Cancer Sci. 2009;100(10):1842-1847.
    • (2009) Cancer Sci , vol.100 , Issue.10 , pp. 1842-1847
    • Seki, R.1    Ohshima, K.2    Fujisaki, T.3
  • 28
    • 45749152667 scopus 로고    scopus 로고
    • Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers
    • Wilson WH, Dunleavy K, Pittaluga S, et al. Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers. J Clin Oncol. 2008;26(16): 2717-2724.
    • (2008) J Clin Oncol , vol.26 , Issue.16 , pp. 2717-2724
    • Wilson, W.H.1    Dunleavy, K.2    Pittaluga, S.3
  • 29
    • 70449365381 scopus 로고    scopus 로고
    • Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - Analyses of cases from two prospective randomized clinical trials
    • Bernd HW, Ziepert M, Thorns C, et al. Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials. Haematologica. 2009;94(11):1569-1580.
    • (2009) Haematologica , vol.94 , Issue.11 , pp. 1569-1580
    • Bernd, H.W.1    Ziepert, M.2    Thorns, C.3
  • 30
    • 0030940076 scopus 로고    scopus 로고
    • Subclassification of diffuse large B-cell lymphomas according to the Kiel classification: Distinction of centroblastic and immunoblastic lymphomas is a significant prognostic risk factor
    • Engelhard M, Brittinger G, Huhn D, et al. Subclassification of diffuse large B-cell lymphomas according to the Kiel classification: distinction of centroblastic and immunoblastic lymphomas is a significant prognostic risk factor. Blood. 1997; 89(7):2291-2297.
    • (1997) Blood , vol.89 , Issue.7 , pp. 2291-2297
    • Engelhard, M.1    Brittinger, G.2    Huhn, D.3
  • 32
    • 0037698992 scopus 로고    scopus 로고
    • Rituximab plus CHOP (R-CHOP) overcomes bcl-2-associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL)
    • Mounier N, Briere J, Gisselbrecht C, et al. Rituximab plus CHOP (R-CHOP) overcomes bcl-2-associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL). Blood. 2003;101(11):4279-4284.
    • (2003) Blood , vol.101 , Issue.11 , pp. 4279-4284
    • Mounier, N.1    Briere, J.2    Gisselbrecht, C.3
  • 33
    • 33645791771 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: A prospective correlative study
    • Winter JN, Weller EA, Horning SJ, et al. Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study. Blood. 2006;107(11): 4207-4213.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4207-4213
    • Winter, J.N.1    Weller, E.A.2    Horning, S.J.3
  • 34
    • 27644488026 scopus 로고    scopus 로고
    • Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
    • Bea S, Zettl A, Wright G, et al. Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood. 2005;106(9):3183-3190.
    • (2005) Blood , vol.106 , Issue.9 , pp. 3183-3190
    • Bea, S.1    Zettl, A.2    Wright, G.3
  • 35
    • 41149136296 scopus 로고    scopus 로고
    • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    • Lenz G, Davis RE, Ngo VN, et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008;319(5870):1676-9.
    • (2008) Science , vol.319 , Issue.5870 , pp. 1676-1679
    • Lenz, G.1    Davis, R.E.2    Ngo, V.N.3
  • 36
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • Compagno M, Lim WK, Grunn A, et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 2009;459(7247):717-721.
    • (2009) Nature , vol.459 , Issue.7247 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.