α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Shao, Hanshuang ^a   Wang, James H C ^a   Pollak, Martin R ^b   Wells, Alan ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ 4; MYOSIN LIGHT CHAIN 2; ACTININ; ACTN4 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; MYH9 PROTEIN, MOUSE; MYOSIN HEAVY CHAIN; MYOSIN II; MYOSIN IIA; MYOSIN IIB; NONMUSCLE MYOSIN TYPE IIB HEAVY CHAIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL FUNCTION; CELL MOTILITY; CELL NUCLEUS; CELL PROLIFERATION; CELL SPREADING; CELL STRESS; CONTROLLED STUDY; CYTOKINESIS; LUNG FIBROBLAST; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; ANIMAL; CELL LINE; CELL MOTION; CELL SHAPE; CYTOLOGY; ELECTRON MICROSCOPY; FIBROBLAST; GENETICS; IMMUNOBLOTTING; LUNG; METABOLISM; MOUSE MUTANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRASTRUCTURE;

MURINAE;

ACTININ; ANIMALS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; IMMUNOBLOTTING; LUNG; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MYOSIN HEAVY CHAINS; MYOSIN TYPE II; NONMUSCLE MYOSIN TYPE IIA; NONMUSCLE MYOSIN TYPE IIB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78649727967     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013921     Document Type: Article

References (27)

1. Otey CA, Carpen O (2004) Alphα-actinin revisited: a fresh look at an old player. Cell Motil Cytoskeleton 58: 104-111.
2. Quick Q, Skalli O (2010) Alphα-actinin 1 and alphα-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. Exp Cell Res 316: 1137-1147.
3. Michaud JL, Hosseini-Abardeh M, Farah K, Kennedy CR (2009) Modulating alphα-actinin-4 dynamics in podocytes. Cell Motil Cytoskeleton 66: 166-178.
4. Honda K, Yamada T, Endo R, Ino Y, Gotoh M, et al. (1998) Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol 140: 1383-1393.
5. Honda K, Yamada T, Hayashida Y, Idogawa M, Sato S, et al. (2005) Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer. Gastroenterology 128: 51-62.
6. Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, et al. (2008) Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas. Clin Cancer Res 14: 5348-5356.
7. Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, et al. (2009) Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol 22: 499-507.
8. Sen S, Dong M, Kumar S (2009) Isoform-specific contributions of alphα-actinin to glioma cell mechanobiology. PLoS One 4: e8427.
9. Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, et al. (2003) Mice deficient in alphα-actinin-4 have severe glomerular disease. J Clin Invest 111: 1683-1690.
10. Dandapani SV, Sugimoto H, Matthews BD, Kolb RJ, Sinha S, et al. (2007) Alphα-actinin-4 is required for normal podocyte adhesion. J Biol Chem 282: 467-477.
11. Mukhina S, Wang YL, Murata-Hori M (2007) Alphα-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis. Dev Cell 13: 554-565.
12. Shao H, Wu C, Wells A (2010) Phosphorylation of alphα-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin. J Biol Chem 285: 2591-2600.
13. Kumeta M, Yoshimura SH, Harata M, Takeyasu K (2010) Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4. J Cell Sci 123: 1020-1030.
14. Tager AM, Kradin RL, LaCamera P, Bercury SD, Campanella GS, et al. (2004) Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10. Am J Respir Cell Mol Biol 31: 395-404.
15. Chen P, Gupta K, Wells A (1994) Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J Cell Biol 124: 547-555.
16. Li B, Lin M, Tang Y, Wang B, Wang JH (2008) A novel functional assessment of the differentiation of micropatterned muscle cells. J Biomech 41: 3349-3353.
17. Butler JP, Tolic-Norrelykke IM, Fabry B, Fredberg JJ (2002) Traction fields, moments, and strain energy that cells exert on their surroundings. Am J Physiol Cell Physiol 282: C595-605.
18. Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A (2004) Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem 279: 14551-14560.
19. Hauge H, Fjelland KE, Sioud M, Aasheim HC (2009) Evidence for the involvement of FAM110C protein in cell spreading and migration. Cell Signal 21: 1866-1873.
20. Allen FD, Asnes CF, Chang P, Elson EL, Lauffenburger DA, et al. (2002) Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. Wound Repair Regen 10: 67-76.
21. Smith KD, Wells A, Lauffenburger DA (2006) Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts. Exp Cell Res 312: 1970-1982.
22. Assoian RK, Klein EA (2008) Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol 18: 347-352.
23. Ghosh K, Ingber DE (2007) Micromechanical control of cell and tissue development: implications for tissue engineering. Adv Drug Deliv Rev 59: 1306-1318.
24. Lauffenburger DA, Horwitz AF (1996) Cell migration: a physically integrated molecular process. Cell 84: 359-369.
25. Choi CK, Vicente-Manzanares M, Zareno J, Whitmore LA, Mogilner A, et al. (2008) Actin and alphα-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. Nat Cell Biol 10: 1039-1050.
26. Beningo KA, Dembo M, Kaverina I, Small JV, Wang YL (2001) Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol 153: 881-888.
27. Low SH, Mukhina S, Srinivas V, Ng CZ, Murata-Hori M (2010) Domain analysis of alphα-actinin reveals new aspects of its association with F-actin during cytokinesis. Exp Cell Res 316: 1925-1934.