Angiogenin levels and ANG genotypes: Dysregulation in amyotrophic lateral sclerosis

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  McLaughlin, Russell Lewis ^a,b   Phukan, Julie ^a,b   McCormack, William ^c   Lynch, David S ^b,d   Greenway, Matthew ^d   Cronin, Simon ^b,d   Saunders, Jean ^c   Slowik, Agnieska ^e   Tomik, Barbara ^e   Andersen, Peter M ^f   Bradley, Daniel G ^a   Jakeman, Phil ^c   Hardiman, Orla ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; PANCREATIC RIBONUCLEASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANG GENE; ARTICLE; CONTROLLED STUDY; GENE; GENE DOSAGE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IRELAND; MAJOR CLINICAL STUDY; POLAND; POPULATION GENETICS; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN; ALLELE; BLOOD; CEREBROSPINAL FLUID; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE;

ALLELES; AMYOTROPHIC LATERAL SCLEROSIS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; IRELAND; LINKAGE DISEQUILIBRIUM; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; RIBONUCLEASE, PANCREATIC; SWEDEN;

EID: 78649720289     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015402     Document Type: Article

References (25)

1. Greenway MJ, Andersen PM, Russ C, Ennis S, Cashman S, et al. (2006) ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Nat Genet 38: 411-413.
2. Subramanian V, Crabtree B, Acharya KR (2008) Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons. Hum Mol Genet 17: 130-149.
3. Wu D, Yu W, Kishikawa H, Folkerth RD, Iafrate AJ, et al. (2007) Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. Ann Neurol 62: 609-617.
4. Gellera C, Colombrita C, Ticozzi N, Castellotti B, Bragato C, et al. (2008) Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis. Neurogenetics 9: 33-40.
5. Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, et al. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 28: 131-138.
6. Rosenstein JM, Krum JM (2004) New roles for VEGF in nervous tissue-beyond blood vessels. Exp Neurol 187: 246-253.
7. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, et al. (2003) VEGFis a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 34: 383-394.
8. Cronin S, Greenway MJ, Ennis S, Kieran D, Green A, et al. (2006) Elevated serum angiogenin levels in ALS. Neurology 67: 1833-1836.17.
9. Devos D, Moreau C, Lassalle P, Perez T, De Seze J, et al. (2004) Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology 62: 2127-2129.
10. Iłzecka J (2004) Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg 106: 289-293.
11. Nygren I, Larsson A, Johansson A, Askmark H (2002) VEGF is increased in serum but not in spinal cord from patients with amyotrophic lateral sclerosis. Neuroreport 13: 2199-2201.
12. Brooks BR (1994) El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis Subcommittee on Motor Neuron Diseases/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial ''Clinical limits of amyotrophic lateral sclerosis'' workshop contributors. J Neurol Sci 124(Suppl): 96-107.
13. Frazer K, Ballinger DG, Cox DR, Hinds DA, Stuve LL, et al. (2007) A second generation human haplotype map of over 31 million SNPs. Nature 449: 851-861.
14. R Development Core Team (2010) R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org. ISBN 3-900051-07-0.
15. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
16. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.18.
17. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229.
18. Pantsulaia Ia, Trofimov S, Kobyliansky E, Livshits G (2006) Genetic and environmental determinants of circulating levels of angiogenin in community-based sample. Clin Endocrinol (Oxf) 64: 271-279.
19. Cronin S, Berger S, Ding J, Schymick JC, Washecka N, et al. (2008) A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet 17: 768-774.
20. Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O (2009) Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet 17: 213-218.
21. Novembre J, Johnson T, Bryc K, Kutalik Z, Boyko AR, et al. (2008) Genes mirror geography within Europe. Nature 456: 98-101.
22. Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, et al. (2008) Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet 17: 3631-3642.
23. Strong MJ (2008) The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9: 323-338.
24. Griffiths-Jones S (2006) miRBase: the microRNA sequence database. Methods Mol Biol 342: 129-138.
25. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, et al. (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129: 1401-1414.