Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to L-arginine infusion - C-11 acetate kinetics revealed by positron emission tomography

Circulation Journal

Volumn 74, Issue 12, 2010, Pages 2702-2711

  Arakawa, Kenichiro ^a   Kudo, Takashi ^a   Ikawa, Masamichi ^a   Morikawa, Norihiro ^a   Kawai, Yasuyuki ^b   Sahashi, Ko ^c   Lee, Jong Dae ^a   Kuriyama, Masaru ^a   Miyamori, Isamu ^a   Okazawa, Hidehiko ^a   Yoneda, Makoto ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

^c AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetate positron emission tomography; Cardiomyopathy; L arginine; MELAS

Indexed keywords

ACETIC ACID; ARGININE; BRAIN NATRIURETIC PEPTIDE; CARBON 11; TRICARBOXYLIC ACID;

ADULT; AEROBIC METABOLISM; ANAEROBIC METABOLISM; ARTICLE; CARDIOMYOPATHY; CITRIC ACID CYCLE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; ENERGY YIELD; FEMALE; GENE MUTATION; HEART MUSCLE BLOOD FLOW; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC MONITORING; HUMAN; HUMAN CELL; MALE; MELAS SYNDROME; METABOLIC RATE; MICROCIRCULATION; NON INVASIVE PROCEDURE; POSITRON EMISSION TOMOGRAPHY; SIGNAL TRANSDUCTION; VASODILATATION;

ACETATES; ADULT; ARGININE; CARBON ISOTOPES; CARDIOMYOPATHIES; CITRIC ACID CYCLE; CORONARY CIRCULATION; ENERGY METABOLISM; FEMALE; HUMANS; MALE; MELAS SYNDROME; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY;

EID: 78649711229     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-10-0044     Document Type: Article

References (35)

1. Shapira Y, Harel S, Russell A. Mitochondrial encephalomyopathies. Israel J Med 1977; 13: 161-164.
2. Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: A distinctive clinical syndrome. Ann Neurol 1984; 16: 481-488.
3. Förster Ch, Hübner G, Müller-Höcker J, Pongratz D, Baierl P, Senger R, et al. Mitochondrial angiopathy in a family with MELAS. Neuropediatrics 1992; 23: 165-168.
4. Manouvrier S, Rötig A, Hannebique G, Gheerbrandt JD, Royer- Legrain G, Munnich A, et al. Point mutation of the mitochondrial tRNALeu gene (A 3243 G) in maternally inherited hypertrophic cardiomyopathy, diabetes mellitus, renal failure, and sensorineural deafness. J Med Genet 1995; 32: 654-656.
5. Anan R, Nakagawa M, Miyata M, Higuchi I, Nakao S, Suehara M, et al. Cardiac involvement in mitochondrial diseases. Circulation 1995; 91: 955-961.
6. Yoneda M, Tanaka M, Nishikimi M, Suzuki H, Tanaka K, Nishizawa M, et al. Pleiotropic molecular defects in energy-transducing complexes in mitochondrial encephalomyopathy (MELAS). J Neurol Sci 1989; 92: 143-158.
7. Ban S, Mori N, Saito K, Mizukami K, Suzuki T, Shiraishi H. An autopsy case of mitochondrial encephalomyopathy (MELAS) with special reference to extra-neuromuscular abnormalities. Acta Pathol Jpn 1992; 42: 818-825.
8. Oldfors A, Tulinius M, Holme E, Kalimo H, Kristiansson B, Eriksson BO. Mitochondrial encephalomyopathy. Acta Neuropathol 1987; 74: 287-293.
9. Ikawa M, Kawai Y, Arakawa K, Tsuchida T, Miyamori I, Kuriyama M, et al. Evaluation of respiratory chain failure in mitochondrial cardiomyopathy by assessments of 99mTc-MIBI washout and 123I-BMIPP/99mTc-MIBI mismatch. Mitochondrion 2007; 7: 164-170.
10. Klein LJ, Visser FC, Knaapen P, Peters JH, Teule GJJ, Visser CA, et al. Carbon-11 acetate as a tracer of myocardial oxygen consumption. Eur J Nucl Med 2001; 28: 651-668.
11. Buxton DB, Nienaber CA, Luxen A, Ratib O, Hansen H, Phelps ME, et al. Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C] acetate and dynamic positron emission tomography. Circulation 1989; 79: 134-142.
12. Wu YW, Naya M, Tsukamoto T, Komatsu H, Morita K, Yoshinaga K, et al. Heterogeneous reduction of myocardial oxidative metabolism in patients with ischemic and dilated cardiomyopathy using C-11 acetate PET. Circ J 2008; 72: 786-792.
13. Okajima Y, Tanabe Y, Takayanagi M, Aotsuka H. A follow up study of myocardial involvement in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Heart 1998; 80: 292-295.
14. Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y, et al. L-arginine improves the symptom of stroke-like episodes in MELAS. Neurology 2005; 64: 710-712.
15. Bing RJ, Hammond MM, Handelsman JC, Powers SR, Spencer FC, Eckenhoff JE, et al. The measurement of coronary blood flow, oxygen consumption, and efficiency of the left ventricle in man. Am Heart J 1949; 38: 1-24.
16. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M. Myocardial efficiency and sympathetic reinnervation after orthotopic heart transplantation: A noninvasive study with positron emission tomography. Circulation 2001; 103: 1881-1886.
17. Beanlands RSB, Bach DS, Raylman R, Armstrong WF, Wilson V, Montieth M, et al. Acute effects of dobutamine on myocardial oxygen consumption and cardiac efficiency measured using carbon-11 acetate kinetics in patients with dilated cardiomyopathy. J Am Coll Cardiol 1993; 22: 1389-1398.
18. Hattori N, Tamaki N, Kudoh T, Masuda I, Magata Y, Kitano H, et al. Abnormality of myocardial oxidative metabolism in noninsulindependent diabetes mellitus. J Nucl Med 1998; 39: 1835-1840.
19. Katz LN, Feinberg H. The relation of cardiac effort to myocardial oxygen consumption and coronary flow. Circ Res 1958; 6: 659-669.
20. Kudo T, Hata T, Kagawa S, Kishibe Y, Iwasaki J, Nakano A, et al. Simple quantification of myocardial perfusion by pixel-by-pixel graphical analysis using carbon-11 acetate and nitrogen-13 ammonia. Nucl Med Commun 2008; 29: 679-685.
21. Yoneda M, Tanno Y, Tsuji S, Attardi G. Detection and quantification of point mutations in mitochondrial DNA by PCR. Methods Enzymol 1996; 264: 432-441.
22. Hatefi Y. The mitochondrial electron transport and oxidative phos phorylation system. Annu Rev Biochem 1985; 54: 1015-1069.
23. Carvalho PA, Chiu ML, Kronauge JF, Kawamura M, Jones AG, Holman BL, et al. Subcellular distribution and analysis of technetium-99m-MIBI in isolated perfused rat hearts. J Nucl Med 1992; 33: 1516-1522.
24. Tamaki N, Morita K, Kuge Y, Tsukamoto E. The role of fatty acids in cardiac imaging. J Nucl Med 2000; 41: 1525-1534.
25. Holt IJ, Harding AE, Morgan-Hughes JA. Deletion of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988; 331: 717-719.
26. Ozawa T, Yoneda M, Tanaka M, Ohno K, Sato W, Suzuki H, et al. Maternal inheritance of mitochondrial DNA in a family with mitochondrial myopathy. Biochem Biophys Res Commun 1988; 154: 1240-1247.
27. Kates AM, Herrero P, Dence C, Soto P, Srinivasan M, Delano DG, et al. Impact of aging on substrate metabolism by the human heart. J Am Col Cardiol 2003; 41: 293-299.
28. Bengel FM, Permanetter B, Ungerer M, Nekolla S, Schwaiger M. Non-invasive estimation of myocardial efficiency using positron emission tomography and carbon-11 acetate: Comparison between the normal and failing human heart. Eur J Nucl Med 2000; 27: 319-326.
29. Gregory SA, MacRae CA, Aziz K, Sims KB, Schmahmann JD, Kardan A, et al. Myocardial blood flow and oxygen consumption in patients with Friedreich's ataxia prior to the onset of cardiomyopathy. Coron Artery Dis 2007; 18: 15-22.
30. Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 1991; 83: 1118-1120.
31. Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation 1994; 89: 2176-2182.
32. Katz AM. Potential deleterious effects of inotropic agents in the therapy of chronic heart failure. Circulation 1986; 73(Suppl III): III-184.
33. Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, Di Bianco R, Zeldis SM, et al. Effect of oral milrinone on mortality in severe chronic heart failure. N Engl J Med 1991; 325: 1468-1475.
34. Beanlands RSB, Nahmias C, Gordon E, Coates G, deKemp R, Firnau G, et al. The effects of ß1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction. Circulation 2000; 102: 2070-2075.
35. Kitaizumi K, Yukiiri K, Masugata H, Shinomiya K, Ohara M, Takinami H, et al. Positron emission tomographic demonstration of myocardial oxidative metabolism in a case of left ventricular restration after cardiac resynchronization therapy. Circ J 2008; 72: 1900-19